The Onset and Progression of Hippocampal Synaptic Plasticity Deficits in the Q175FDN Mouse Model of Huntington Disease

The Onset and Progression of Hippocampal Synaptic Plasticity Deficits in the Q175FDN Mouse Model of Huntington Disease

Huntington disease (HD) is an inherited neurodegenerative disease characterized by a clinical triad of motor, psychiatric and cognitive symptoms. HD is caused by a CAG repeat expansion in the gene encoding the huntingtin protein. Homozygosity for the HD-causing mutation is extremely rare; thus, the...

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Bibliographic Details
Main Authors: Jade G. Quirion, Matthew P. Parsons
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
long-term potentiation
Huntington disease
huntingtin
neurodegenerative disease
synaptic plasticity
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00326/full

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