Adenosine and Adenosine Receptors: Advances in Atrial Fibrillation
Atrial fibrillation (AF) is the most common arrhythmia in the world. Because the key to developing innovative therapies that limit the onset and the progression of AF is to fully understand the underlying molecular mechanisms of AF, the aim of the present narrative review is to report the most recen...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/11/2963 |
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| author | Baptiste Maille Nathalie Lalevée Marion Marlinge Juliette Vahdat Giovanna Mottola Clara Degioanni Lucille De Maria Victor Klein Franck Thuny Frédéric Franceschi Jean-Claude Deharo Régis Guieu Julien Fromonot |
| author_facet | Baptiste Maille Nathalie Lalevée Marion Marlinge Juliette Vahdat Giovanna Mottola Clara Degioanni Lucille De Maria Victor Klein Franck Thuny Frédéric Franceschi Jean-Claude Deharo Régis Guieu Julien Fromonot |
| author_sort | Baptiste Maille |
| collection | DOAJ |
| description | Atrial fibrillation (AF) is the most common arrhythmia in the world. Because the key to developing innovative therapies that limit the onset and the progression of AF is to fully understand the underlying molecular mechanisms of AF, the aim of the present narrative review is to report the most recent advances in the potential role of the adenosinergic system in the pathophysiology of AF. After a comprehensive approach describing adenosinergic system signaling and the mechanisms of the initiation and maintenance of AF, we address the interactions of the adenosinergic system’s signaling with AF. Indeed, adenosine release can activate four G-coupled membrane receptors, named A<sub>1</sub>, A<sub>2A</sub>, A<sub>2B</sub> and A<sub>3</sub>. Activation of the A<sub>2A</sub> receptors can promote the occurrence of delayed depolarization, while activation of the A<sub>1</sub> receptors can shorten the action potential’s duration and induce the resting membrane’s potential hyperpolarization, which promote pulmonary vein firing, stabilize the AF rotors and allow for functional reentry. Moreover, the A<sub>2B</sub> receptors have been associated with atrial fibrosis homeostasis. Finally, the adenosinergic system can modulate the autonomous nervous system and is associated with AF risk factors. A question remains regarding adenosine release and the adenosine receptors’ activation and whether this would be a cause or consequence of AF. |
| first_indexed | 2024-03-09T18:26:59Z |
| format | Article |
| id | doaj.art-07085bdb16fb455699db092a62042353 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T18:26:59Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-07085bdb16fb455699db092a620423532023-11-24T07:46:55ZengMDPI AGBiomedicines2227-90592022-11-011011296310.3390/biomedicines10112963Adenosine and Adenosine Receptors: Advances in Atrial FibrillationBaptiste Maille0Nathalie Lalevée1Marion Marlinge2Juliette Vahdat3Giovanna Mottola4Clara Degioanni5Lucille De Maria6Victor Klein7Franck Thuny8Frédéric Franceschi9Jean-Claude Deharo10Régis Guieu11Julien Fromonot12Department of Cardiology, Timone University Hospital, 13005 Marseille, FranceCentre for Nutrition and Cardiovascular Disease (C2VN), INSERM, INRAE, Aix Marseille University, 13005 Marseille, FranceCentre for Nutrition and Cardiovascular Disease (C2VN), INSERM, INRAE, Aix Marseille University, 13005 Marseille, FranceCentre for Nutrition and Cardiovascular Disease (C2VN), INSERM, INRAE, Aix Marseille University, 13005 Marseille, FranceCentre for Nutrition and Cardiovascular Disease (C2VN), INSERM, INRAE, Aix Marseille University, 13005 Marseille, FranceLaboratory of Biochemistry, Timone University Hospital, AP-HM, 13005 Marseille, FranceLaboratory of Biochemistry, Timone University Hospital, AP-HM, 13005 Marseille, FranceDepartment of Cardiology, Timone University Hospital, 13005 Marseille, FranceCentre for Nutrition and Cardiovascular Disease (C2VN), INSERM, INRAE, Aix Marseille University, 13005 Marseille, FranceDepartment of Cardiology, Timone University Hospital, 13005 Marseille, FranceDepartment of Cardiology, Timone University Hospital, 13005 Marseille, FranceCentre for Nutrition and Cardiovascular Disease (C2VN), INSERM, INRAE, Aix Marseille University, 13005 Marseille, FranceCentre for Nutrition and Cardiovascular Disease (C2VN), INSERM, INRAE, Aix Marseille University, 13005 Marseille, FranceAtrial fibrillation (AF) is the most common arrhythmia in the world. Because the key to developing innovative therapies that limit the onset and the progression of AF is to fully understand the underlying molecular mechanisms of AF, the aim of the present narrative review is to report the most recent advances in the potential role of the adenosinergic system in the pathophysiology of AF. After a comprehensive approach describing adenosinergic system signaling and the mechanisms of the initiation and maintenance of AF, we address the interactions of the adenosinergic system’s signaling with AF. Indeed, adenosine release can activate four G-coupled membrane receptors, named A<sub>1</sub>, A<sub>2A</sub>, A<sub>2B</sub> and A<sub>3</sub>. Activation of the A<sub>2A</sub> receptors can promote the occurrence of delayed depolarization, while activation of the A<sub>1</sub> receptors can shorten the action potential’s duration and induce the resting membrane’s potential hyperpolarization, which promote pulmonary vein firing, stabilize the AF rotors and allow for functional reentry. Moreover, the A<sub>2B</sub> receptors have been associated with atrial fibrosis homeostasis. Finally, the adenosinergic system can modulate the autonomous nervous system and is associated with AF risk factors. A question remains regarding adenosine release and the adenosine receptors’ activation and whether this would be a cause or consequence of AF.https://www.mdpi.com/2227-9059/10/11/2963adenosineadenosine receptorsatrial fibrillationarrhythmia |
| spellingShingle | Baptiste Maille Nathalie Lalevée Marion Marlinge Juliette Vahdat Giovanna Mottola Clara Degioanni Lucille De Maria Victor Klein Franck Thuny Frédéric Franceschi Jean-Claude Deharo Régis Guieu Julien Fromonot Adenosine and Adenosine Receptors: Advances in Atrial Fibrillation Biomedicines adenosine adenosine receptors atrial fibrillation arrhythmia |
| title | Adenosine and Adenosine Receptors: Advances in Atrial Fibrillation |
| title_full | Adenosine and Adenosine Receptors: Advances in Atrial Fibrillation |
| title_fullStr | Adenosine and Adenosine Receptors: Advances in Atrial Fibrillation |
| title_full_unstemmed | Adenosine and Adenosine Receptors: Advances in Atrial Fibrillation |
| title_short | Adenosine and Adenosine Receptors: Advances in Atrial Fibrillation |
| title_sort | adenosine and adenosine receptors advances in atrial fibrillation |
| topic | adenosine adenosine receptors atrial fibrillation arrhythmia |
| url | https://www.mdpi.com/2227-9059/10/11/2963 |
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