NADPH oxidase inhibitor VAS2870 prevents staurosporine-induced cell death in rat astrocytes
Astrocytes maintain central nerve system homeostasis and are relatively resistant to cell death. Dysfunction of cell death mechanisms may underlie glioblastoma genesis and resistance to cancer therapy; therefore more detailed understanding of astrocytic death modalities is needed in order to design...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2019-01-01
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| Series: | Radiology and Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/raon-2019-0002 |
| _version_ | 1797848549786910720 |
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| author | Simenc Janez Juric Damijana Mojca Lipnik-Stangelj Metoda |
| author_facet | Simenc Janez Juric Damijana Mojca Lipnik-Stangelj Metoda |
| author_sort | Simenc Janez |
| collection | DOAJ |
| description | Astrocytes maintain central nerve system homeostasis and are relatively resistant to cell death. Dysfunction of cell death mechanisms may underlie glioblastoma genesis and resistance to cancer therapy; therefore more detailed understanding of astrocytic death modalities is needed in order to design effective therapy. The purpose of this study was to determine the effect of VAS2870, a pan-NADPH oxidase inhibitor, on staurosporine-induced cell death in astrocytes. |
| first_indexed | 2024-04-09T18:29:21Z |
| format | Article |
| id | doaj.art-0709caceaafd44f99c064efb6e8ed0f2 |
| institution | Directory Open Access Journal |
| issn | 1581-3207 |
| language | English |
| last_indexed | 2024-04-09T18:29:21Z |
| publishDate | 2019-01-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Radiology and Oncology |
| spelling | doaj.art-0709caceaafd44f99c064efb6e8ed0f22023-04-11T17:19:27ZengSciendoRadiology and Oncology1581-32072019-01-01531697610.2478/raon-2019-0002raon-2019-0002NADPH oxidase inhibitor VAS2870 prevents staurosporine-induced cell death in rat astrocytesSimenc Janez0Juric Damijana Mojca1Lipnik-Stangelj Metoda2University of Ljubljana, Faculty of Medicine, Department of Pharmacology and Experimental Toxicology, Ljubljana, SloveniaUniversity of Ljubljana, Faculty of Medicine, Department of Pharmacology and Experimental Toxicology, Ljubljana, SloveniaUniversity of Ljubljana, Faculty of Medicine, Department of Pharmacology and Experimental Toxicology, Ljubljana, SloveniaAstrocytes maintain central nerve system homeostasis and are relatively resistant to cell death. Dysfunction of cell death mechanisms may underlie glioblastoma genesis and resistance to cancer therapy; therefore more detailed understanding of astrocytic death modalities is needed in order to design effective therapy. The purpose of this study was to determine the effect of VAS2870, a pan-NADPH oxidase inhibitor, on staurosporine-induced cell death in astrocytes.https://doi.org/10.2478/raon-2019-0002astrocytesvas2870mitochondrial potentialatpreactive oxygen speciescell death |
| spellingShingle | Simenc Janez Juric Damijana Mojca Lipnik-Stangelj Metoda NADPH oxidase inhibitor VAS2870 prevents staurosporine-induced cell death in rat astrocytes Radiology and Oncology astrocytes vas2870 mitochondrial potential atp reactive oxygen species cell death |
| title | NADPH oxidase inhibitor VAS2870 prevents staurosporine-induced cell death in rat astrocytes |
| title_full | NADPH oxidase inhibitor VAS2870 prevents staurosporine-induced cell death in rat astrocytes |
| title_fullStr | NADPH oxidase inhibitor VAS2870 prevents staurosporine-induced cell death in rat astrocytes |
| title_full_unstemmed | NADPH oxidase inhibitor VAS2870 prevents staurosporine-induced cell death in rat astrocytes |
| title_short | NADPH oxidase inhibitor VAS2870 prevents staurosporine-induced cell death in rat astrocytes |
| title_sort | nadph oxidase inhibitor vas2870 prevents staurosporine induced cell death in rat astrocytes |
| topic | astrocytes vas2870 mitochondrial potential atp reactive oxygen species cell death |
| url | https://doi.org/10.2478/raon-2019-0002 |
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