Exosomes in the Treatment of Pancreatic Cancer: A Moonshot to PDAC Treatment?
Pancreatic Ductal Adenocarcinoma (PDAC) constitutes a leading cause of cancer death globally. Its mortality remains unaltered despite the considerable scientific progress made in the fields of diagnostics and treatment. Exosomes comprise of small extracellular vesicles secreted by nearly all cells;...
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| Format: | Article |
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MDPI AG
2022-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/7/3620 |
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| author | Stavros P. Papadakos Nikolaos Dedes Alexandros Pergaris Maria Gazouli Stamatios Theocharis |
| author_facet | Stavros P. Papadakos Nikolaos Dedes Alexandros Pergaris Maria Gazouli Stamatios Theocharis |
| author_sort | Stavros P. Papadakos |
| collection | DOAJ |
| description | Pancreatic Ductal Adenocarcinoma (PDAC) constitutes a leading cause of cancer death globally. Its mortality remains unaltered despite the considerable scientific progress made in the fields of diagnostics and treatment. Exosomes comprise of small extracellular vesicles secreted by nearly all cells; their cargo contains a vast array of biomolecules, such as proteins and microRNAs. It is currently established that their role as messengers is central to a plethora of both physiologic and pathologic processes. Accumulating data have shed light on their contributions to carcinogenesis, metastasis, and immunological response. Meanwhile, the advancement of personalized targeted therapies into everyday clinical practice necessitates the development of cost-efficient treatment approaches. The role of exosomes is currently being extensively investigated towards this direction. This review aims to summarize the current pre-clinical and clinical evidence regarding the effects of exosomal applications in the timely diagnosis, prognosis, and therapeutic management of pancreatic cancer. |
| first_indexed | 2024-03-09T11:47:06Z |
| format | Article |
| id | doaj.art-070a2be0578b48de825656f5840edfcc |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T11:47:06Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-070a2be0578b48de825656f5840edfcc2023-11-30T23:19:35ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-03-01237362010.3390/ijms23073620Exosomes in the Treatment of Pancreatic Cancer: A Moonshot to PDAC Treatment?Stavros P. Papadakos0Nikolaos Dedes1Alexandros Pergaris2Maria Gazouli3Stamatios Theocharis4First Department of Pathology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceFirst Department of Pathology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceFirst Department of Pathology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceLaboratory of Biology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceFirst Department of Pathology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreecePancreatic Ductal Adenocarcinoma (PDAC) constitutes a leading cause of cancer death globally. Its mortality remains unaltered despite the considerable scientific progress made in the fields of diagnostics and treatment. Exosomes comprise of small extracellular vesicles secreted by nearly all cells; their cargo contains a vast array of biomolecules, such as proteins and microRNAs. It is currently established that their role as messengers is central to a plethora of both physiologic and pathologic processes. Accumulating data have shed light on their contributions to carcinogenesis, metastasis, and immunological response. Meanwhile, the advancement of personalized targeted therapies into everyday clinical practice necessitates the development of cost-efficient treatment approaches. The role of exosomes is currently being extensively investigated towards this direction. This review aims to summarize the current pre-clinical and clinical evidence regarding the effects of exosomal applications in the timely diagnosis, prognosis, and therapeutic management of pancreatic cancer.https://www.mdpi.com/1422-0067/23/7/3620pancreatic cancerexosomesbiomarkersdiagnosisprognosistherapy |
| spellingShingle | Stavros P. Papadakos Nikolaos Dedes Alexandros Pergaris Maria Gazouli Stamatios Theocharis Exosomes in the Treatment of Pancreatic Cancer: A Moonshot to PDAC Treatment? International Journal of Molecular Sciences pancreatic cancer exosomes biomarkers diagnosis prognosis therapy |
| title | Exosomes in the Treatment of Pancreatic Cancer: A Moonshot to PDAC Treatment? |
| title_full | Exosomes in the Treatment of Pancreatic Cancer: A Moonshot to PDAC Treatment? |
| title_fullStr | Exosomes in the Treatment of Pancreatic Cancer: A Moonshot to PDAC Treatment? |
| title_full_unstemmed | Exosomes in the Treatment of Pancreatic Cancer: A Moonshot to PDAC Treatment? |
| title_short | Exosomes in the Treatment of Pancreatic Cancer: A Moonshot to PDAC Treatment? |
| title_sort | exosomes in the treatment of pancreatic cancer a moonshot to pdac treatment |
| topic | pancreatic cancer exosomes biomarkers diagnosis prognosis therapy |
| url | https://www.mdpi.com/1422-0067/23/7/3620 |
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