MCC950 ameliorates cognitive function by reducing white matter microstructure damage in rats after SAH
Neuroinflammation and white matter microstructure damage are important causes of cognitive impairment after subarachnoid hemorrhage (SAH). Nod-like receptor protein 3 (NLRP3) plays an important role in neuroinflammation after SAH and may be a potential therapeutic target for treatment of white matte...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | Brain Research Bulletin |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0361923023001685 |
| _version_ | 1797677653958852608 |
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| author | Yunchuan Cao Yingwen Wang Xiaoguo Li Xiaomin Yang Bo Zeng Zongduo Guo |
| author_facet | Yunchuan Cao Yingwen Wang Xiaoguo Li Xiaomin Yang Bo Zeng Zongduo Guo |
| author_sort | Yunchuan Cao |
| collection | DOAJ |
| description | Neuroinflammation and white matter microstructure damage are important causes of cognitive impairment after subarachnoid hemorrhage (SAH). Nod-like receptor protein 3 (NLRP3) plays an important role in neuroinflammation after SAH and may be a potential therapeutic target for treatment of white matter microstructure injury. In this study, we observed whether MCC950, a specific inhibitor of the NLRP3 inflammasome, exerted a therapeutic effect after SAH. The SAH model was induced by endovascular perforation in SpragueDawley rats. MCC950 was injected intraperitoneally 1 h after SAH at a dose of 10 mg/kg. The results showed that MCC950 significantly attenuated white matter microstructure damage in some brain regions, and behavioral experiments confirmed that MCC950 ameliorated cognitive function in rats after SAH, which may provide a new method for the treatment of cognitive dysfunction in SAH patients. |
| first_indexed | 2024-03-11T22:48:24Z |
| format | Article |
| id | doaj.art-070c2f70264743a58a608089816c39f9 |
| institution | Directory Open Access Journal |
| issn | 1873-2747 |
| language | English |
| last_indexed | 2024-03-11T22:48:24Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Research Bulletin |
| spelling | doaj.art-070c2f70264743a58a608089816c39f92023-09-22T04:37:56ZengElsevierBrain Research Bulletin1873-27472023-10-01202110743MCC950 ameliorates cognitive function by reducing white matter microstructure damage in rats after SAHYunchuan Cao0Yingwen Wang1Xiaoguo Li2Xiaomin Yang3Bo Zeng4Zongduo Guo5Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, ChinaCorresponding author at: Department of Neurosurgery, the First Affiliated Hospital of Chongqing Medical University, NO.1 of Youyi Road, Yuzhong District, 400016, Chongqing, China.; Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, ChinaNeuroinflammation and white matter microstructure damage are important causes of cognitive impairment after subarachnoid hemorrhage (SAH). Nod-like receptor protein 3 (NLRP3) plays an important role in neuroinflammation after SAH and may be a potential therapeutic target for treatment of white matter microstructure injury. In this study, we observed whether MCC950, a specific inhibitor of the NLRP3 inflammasome, exerted a therapeutic effect after SAH. The SAH model was induced by endovascular perforation in SpragueDawley rats. MCC950 was injected intraperitoneally 1 h after SAH at a dose of 10 mg/kg. The results showed that MCC950 significantly attenuated white matter microstructure damage in some brain regions, and behavioral experiments confirmed that MCC950 ameliorated cognitive function in rats after SAH, which may provide a new method for the treatment of cognitive dysfunction in SAH patients.http://www.sciencedirect.com/science/article/pii/S0361923023001685Subarachnoid hemorrhageWhite matter microstructureCognitive functionNLRP3 inflammasomeMCC950 |
| spellingShingle | Yunchuan Cao Yingwen Wang Xiaoguo Li Xiaomin Yang Bo Zeng Zongduo Guo MCC950 ameliorates cognitive function by reducing white matter microstructure damage in rats after SAH Brain Research Bulletin Subarachnoid hemorrhage White matter microstructure Cognitive function NLRP3 inflammasome MCC950 |
| title | MCC950 ameliorates cognitive function by reducing white matter microstructure damage in rats after SAH |
| title_full | MCC950 ameliorates cognitive function by reducing white matter microstructure damage in rats after SAH |
| title_fullStr | MCC950 ameliorates cognitive function by reducing white matter microstructure damage in rats after SAH |
| title_full_unstemmed | MCC950 ameliorates cognitive function by reducing white matter microstructure damage in rats after SAH |
| title_short | MCC950 ameliorates cognitive function by reducing white matter microstructure damage in rats after SAH |
| title_sort | mcc950 ameliorates cognitive function by reducing white matter microstructure damage in rats after sah |
| topic | Subarachnoid hemorrhage White matter microstructure Cognitive function NLRP3 inflammasome MCC950 |
| url | http://www.sciencedirect.com/science/article/pii/S0361923023001685 |
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