MCC950 ameliorates cognitive function by reducing white matter microstructure damage in rats after SAH

MCC950 ameliorates cognitive function by reducing white matter microstructure damage in rats after SAH

Neuroinflammation and white matter microstructure damage are important causes of cognitive impairment after subarachnoid hemorrhage (SAH). Nod-like receptor protein 3 (NLRP3) plays an important role in neuroinflammation after SAH and may be a potential therapeutic target for treatment of white matte...

Full description

Bibliographic Details
Main Authors:	Yunchuan Cao, Yingwen Wang, Xiaoguo Li, Xiaomin Yang, Bo Zeng, Zongduo Guo
Format:	Article
Language:	English
Published:	Elsevier 2023-10-01
Series:	Brain Research Bulletin
Subjects:	Subarachnoid hemorrhage White matter microstructure Cognitive function NLRP3 inflammasome MCC950
Online Access:	http://www.sciencedirect.com/science/article/pii/S0361923023001685

Similar Items

Inhibiting the NLRP3 Inflammasome Activation with MCC950 Ameliorates Diabetic Encephalopathy in db/db Mice
by: Yadong Zhai, et al.
Published: (2018-02-01)

Intraperitoneal Injection of MCC950 Inhibits the Progression of Myopia in Form-Deprivation Myopic Mice
by: Zhengyu Chen, et al.
Published: (2023-10-01)

Adenine model of chronic renal failure in rats to determine whether MCC950, an NLRP3 inflammasome inhibitor, is a renopreventive
by: Mahmoud S. Sabra, et al.
Published: (2023-12-01)

Targeting the NLRP3 Inflammasome With Inhibitor MCC950 Prevents Aortic Aneurysms and Dissections in Mice
by: Pingping Ren, et al.
Published: (2020-04-01)

A small molecule inhibitor MCC950 ameliorates kidney injury in diabetic nephropathy by inhibiting NLRP3 inflammasome activation
by: Zhang C, et al.
Published: (2019-08-01)

Therapeutic potential of MCC950, a specific inhibitor of NLRP3 inflammasome in systemic lupus erythematosus
by: Xiaoxiao Wu, et al.
Published: (2024-03-01)

Inhibiting the inflammasome with MCC950 counteracts muscle pyroptosis and improves Duchenne muscular dystrophy
by: Nicolas Dubuisson, et al.
Published: (2022-12-01)

MCC950 Ameliorates Diabetic Muscle Atrophy in Mice by Inhibition of Pyroptosis and Its Synergistic Effect with Aerobic Exercise
by: Xiaoyu Yan, et al.
Published: (2024-02-01)

Salvianolic acid B ameliorates neuroinflammation and neuronal injury via blocking NLRP3 inflammasome and promoting SIRT1 in experimental subarachnoid hemorrhage
by: Dayong Xia, et al.
Published: (2023-07-01)

MCC950, a Selective Inhibitor of NLRP3 Inflammasome, Reduces the Inflammatory Response and Improves Neurological Outcomes in Mice Model of Spinal Cord Injury
by: Jianhang Jiao, et al.
Published: (2020-03-01)

MCC950, a Selective NLRP3 Inhibitor, Attenuates Adverse Cardiac Remodeling Following Heart Failure Through Improving the Cardiometabolic Dysfunction in Obese Mice
by: Menglong Wang, et al.
Published: (2022-05-01)

NLRP3 inflammasome and its inhibitors: a review
by: Bo-Zong eShao, et al.
Published: (2015-11-01)

Protection of Mcc950 against H<sub>2</sub>O<sub>2</sub>-induced inflammatory injury in ARPE-19 cells
by: Shu-Yan Li, et al.
Published: (2018-09-01)

MCC950 Ameliorates Acute Liver Injury Through Modulating Macrophage Polarization and Myeloid-Derived Suppressor Cells Function
by: Wei Yan, et al.
Published: (2021-11-01)

Pharmacological Inhibitors of the NLRP3 Inflammasome
by: Ayesha Zahid, et al.
Published: (2019-10-01)

Development of Fluorescent and Biotin Probes Targeting NLRP3
by: Tim Keuler, et al.
Published: (2021-04-01)

Normothermic ex vivo heart perfusion with NLRP3 inflammasome inhibitor Mcc950 treatment improves cardiac function of circulatory death hearts after transplantation
by: Liwei Xu, et al.
Published: (2023-03-01)

NLRP3 Inhibition Reduces rt-PA Induced Endothelial Dysfunction under Ischemic Conditions
by: Maximilian Bellut, et al.
Published: (2022-03-01)

Effects of Blocking NLRP3 Inflammasome on Type II Innate Lymphoid Cell Response in Allergic Rhinitis
by: Guoqing Gong, et al.
Published: (2023-09-01)

NLRP3 Inflammasome Assembly in Neutrophils Is Supported by PAD4 and Promotes NETosis Under Sterile Conditions
by: Patrick Münzer, et al.
Published: (2021-05-01)

Effectiveness of NLRP3 Inhibitor as a Non-Hormonal Treatment for ovarian endometriosis
by: Mayuko Murakami, et al.
Published: (2022-03-01)

Selective NLRP3 inflammasome inhibitor reduces neuroinflammation and improves long-term neurological outcomes in a murine model of traumatic brain injury
by: Xin Xu, et al.
Published: (2018-09-01)

Specific inhibition of the NLRP3 inflammasome suppresses immune overactivation and alleviates COVID-19 like pathology in mice
by: Jianxiong Zeng, et al.
Published: (2022-01-01)

Inhibition of the NOD-Like Receptor Protein 3 Inflammasome Is Protective in Juvenile Influenza A Virus Infection
by: Bria M. Coates, et al.
Published: (2017-07-01)

NLRP3-Inflammasome Inhibition during Respiratory Virus Infection Abrogates Lung Immunopathology and Long-Term Airway Disease Development
by: Carrie-Anne Malinczak, et al.
Published: (2021-04-01)

NLRP3 inflammasome up-regulates major histocompatibility complex class I expression and promotes inflammatory infiltration in polymyositis
by: Ping Xia, et al.
Published: (2022-08-01)

The NLRP3 inflammasome: a potential therapeutic target for traumatic brain injury
by: Saifudeen Ismael, et al.
Published: (2021-01-01)

Novel role of NLRP3-inflammasome in regulation of lipogenesis in fasting-induced hepatic steatosis
by: Liu B, et al.
Published: (2019-05-01)

TLR4-Pathway-Associated Biomarkers in Subarachnoid Hemorrhage (SAH): Potential Targets for Future Anti-Inflammatory Therapies
by: Rebecca Heinz, et al.
Published: (2022-10-01)

Influenza a virus triggers acute exacerbation of chronic obstructive pulmonary disease by increasing proinflammatory cytokines secretion via NLRP3 inflammasome activation
by: Shuang Ji, et al.
Published: (2022-06-01)

NLRP3 inhibition attenuates early brain injury and delayed cerebral vasospasm after subarachnoid hemorrhage
by: William S. Dodd, et al.
Published: (2021-07-01)

Fluoxetine-enhanced autophagy ameliorates early brain injury via inhibition of NLRP3 inflammasome activation following subarachnoid hemorrhage in rats
by: Jian-ru Li, et al.
Published: (2017-09-01)

Metformin Inhibits NLR Family Pyrin Domain Containing 3 (NLRP)-Relevant Neuroinflammation via an Adenosine-5′-Monophosphate-Activated Protein Kinase (AMPK)-Dependent Pathway to Alleviate Early Brain Injury After Subarachnoid Hemorrhage in Mice
by: Lei Jin, et al.
Published: (2022-03-01)

TAK1 mediates neuronal pyroptosis in early brain injury after subarachnoid hemorrhage
by: Pengfei Xu, et al.
Published: (2021-08-01)

Assessment of AI-Based Protein Structure Prediction for the NLRP3 Target
by: Jian Yin, et al.
Published: (2022-09-01)

Rasd1 aggravates white matter injury after subarachnoid hemorrhage in rats by promoting ferroptosis in oligodendrocytes
by: 10.16016/j.2097-0927.202302069, et al.
Published: (2023-09-01)

Electroacupuncture alleviates early brain injury via modulating microglia polarization and suppressing neuroinflammation in a rat model of subarachnoid hemorrhage
by: Yingwen Wang, et al.
Published: (2023-03-01)

NLRP1 Inflammasomes: A Potential Target for the Treatment of Several Types of Brain Injury
by: Liang Mi, et al.
Published: (2022-05-01)

Computational screening of benzophenone integrated derivatives (BIDs) targeting the NACHT domain of the potential target NLRP3 inflammasome
by: Shashank M. Patil, et al.
Published: (2022-10-01)

Hyperglycemia Aggravates Periodontitis via Autophagy Impairment and ROS-Inflammasome-Mediated Macrophage Pyroptosis
by: Zhenxing Zhao, et al.
Published: (2023-03-01)