DITERPENOS ENT-ABIETANOS DE Euphorbia phosphorea (EUPHORBIACEAE)
Phytochemical study of the roots of Euphorbia phosphorea Mart. (Euphorbiaceae) was carried out through chromatographic techniques, resulting in the isolation of a new ent-abietane diterpene named 11β,12β-dihydroxy-ent-abieta-8(14),13(15)-dien-16,12α-olide (1), and of nine known ent-abietane diterpen...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Química
2022-12-01
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| Series: | Química Nova |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422022000901092&tlng=pt |
| _version_ | 1798004209571856384 |
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| author | Roseana A. R. Meireles Lucas S. Abreu Joanda Paolla R. e Silva Andreza B. S. Cavalcanti Renata Priscila B. de Menezes Gabriela Cristina S. Rodrigues Valnês S. Rodrigues Junior José Iranildo M. de Melo Massuo Jorge Kato Vicente Carlos de O. Costa Marcus Tullius Scotti Josean F. Tavares |
| author_facet | Roseana A. R. Meireles Lucas S. Abreu Joanda Paolla R. e Silva Andreza B. S. Cavalcanti Renata Priscila B. de Menezes Gabriela Cristina S. Rodrigues Valnês S. Rodrigues Junior José Iranildo M. de Melo Massuo Jorge Kato Vicente Carlos de O. Costa Marcus Tullius Scotti Josean F. Tavares |
| author_sort | Roseana A. R. Meireles |
| collection | DOAJ |
| description | Phytochemical study of the roots of Euphorbia phosphorea Mart. (Euphorbiaceae) was carried out through chromatographic techniques, resulting in the isolation of a new ent-abietane diterpene named 11β,12β-dihydroxy-ent-abieta-8(14),13(15)-dien-16,12α-olide (1), and of nine known ent-abietane diterpenes jolkinolide A (2), jolkinolide E (3), euphorin H (4), euphopilolide (5) jolkinolide F (6), ent-12-hydroxy-12[R]-abieta-8(14),13(15)-dien-16,12-olide (7), ent-11α-hydroxyabieta-8(14),13(15)-dien-16,12α-olide (8), 17-hydroxyjolkinolide B (9) and caudicifolin (10). The structures of all compounds were established using spectroscopic techniques such as 1D and 2D NMR, and the structure of the compound 1 was established also with MS, IR and ECD. All compounds were submitted to an in silico study through of a predictive model and then submitted to in vitro tests against Mycobacterium tuberculosis and M. smegmatis for evaluation of their antimycobacterial activity. Compounds 5 and 9 showed mycobacterial growth inhibition with MIC values of 62.5 μM against M. tuberculosis and M. smegmatis, respectively. |
| first_indexed | 2024-04-11T12:19:59Z |
| format | Article |
| id | doaj.art-070f5ccd2c1a436ba6baf3b633ae21b9 |
| institution | Directory Open Access Journal |
| issn | 1678-7064 |
| language | English |
| last_indexed | 2024-04-11T12:19:59Z |
| publishDate | 2022-12-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Química Nova |
| spelling | doaj.art-070f5ccd2c1a436ba6baf3b633ae21b92022-12-22T04:24:06ZengSociedade Brasileira de QuímicaQuímica Nova1678-70642022-12-014591092109710.21577/0100-4042.20170932DITERPENOS ENT-ABIETANOS DE Euphorbia phosphorea (EUPHORBIACEAE)Roseana A. R. MeirelesLucas S. AbreuJoanda Paolla R. e SilvaAndreza B. S. CavalcantiRenata Priscila B. de MenezesGabriela Cristina S. RodriguesValnês S. Rodrigues JuniorJosé Iranildo M. de MeloMassuo Jorge KatoVicente Carlos de O. CostaMarcus Tullius ScottiJosean F. Tavareshttps://orcid.org/0000-0003-0293-2605Phytochemical study of the roots of Euphorbia phosphorea Mart. (Euphorbiaceae) was carried out through chromatographic techniques, resulting in the isolation of a new ent-abietane diterpene named 11β,12β-dihydroxy-ent-abieta-8(14),13(15)-dien-16,12α-olide (1), and of nine known ent-abietane diterpenes jolkinolide A (2), jolkinolide E (3), euphorin H (4), euphopilolide (5) jolkinolide F (6), ent-12-hydroxy-12[R]-abieta-8(14),13(15)-dien-16,12-olide (7), ent-11α-hydroxyabieta-8(14),13(15)-dien-16,12α-olide (8), 17-hydroxyjolkinolide B (9) and caudicifolin (10). The structures of all compounds were established using spectroscopic techniques such as 1D and 2D NMR, and the structure of the compound 1 was established also with MS, IR and ECD. All compounds were submitted to an in silico study through of a predictive model and then submitted to in vitro tests against Mycobacterium tuberculosis and M. smegmatis for evaluation of their antimycobacterial activity. Compounds 5 and 9 showed mycobacterial growth inhibition with MIC values of 62.5 μM against M. tuberculosis and M. smegmatis, respectively.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422022000901092&tlng=pt |
| spellingShingle | Roseana A. R. Meireles Lucas S. Abreu Joanda Paolla R. e Silva Andreza B. S. Cavalcanti Renata Priscila B. de Menezes Gabriela Cristina S. Rodrigues Valnês S. Rodrigues Junior José Iranildo M. de Melo Massuo Jorge Kato Vicente Carlos de O. Costa Marcus Tullius Scotti Josean F. Tavares DITERPENOS ENT-ABIETANOS DE Euphorbia phosphorea (EUPHORBIACEAE) Química Nova |
| title | DITERPENOS ENT-ABIETANOS DE Euphorbia phosphorea (EUPHORBIACEAE) |
| title_full | DITERPENOS ENT-ABIETANOS DE Euphorbia phosphorea (EUPHORBIACEAE) |
| title_fullStr | DITERPENOS ENT-ABIETANOS DE Euphorbia phosphorea (EUPHORBIACEAE) |
| title_full_unstemmed | DITERPENOS ENT-ABIETANOS DE Euphorbia phosphorea (EUPHORBIACEAE) |
| title_short | DITERPENOS ENT-ABIETANOS DE Euphorbia phosphorea (EUPHORBIACEAE) |
| title_sort | diterpenos ent abietanos de euphorbia phosphorea euphorbiaceae |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422022000901092&tlng=pt |
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