Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate
Farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase (FPPS/GGPPS) is a key enzyme in the synthesis of isoprenic chains. Risedronate, a bisphosphonate containing nitrogen (N-BP), is a potent inhibitor of blood stage Plasmodium. Here, we show that P. falciparum parasites overexpressing FP...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2018-08-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762018001000400&lng=en&tlng=en |
| _version_ | 1797758413246038016 |
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| author | Heloisa B Gabriel Mauro F Azevedo Emília A Kimura Alejandro M Katzin |
| author_facet | Heloisa B Gabriel Mauro F Azevedo Emília A Kimura Alejandro M Katzin |
| author_sort | Heloisa B Gabriel |
| collection | DOAJ |
| description | Farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase (FPPS/GGPPS) is a key enzyme in the synthesis of isoprenic chains. Risedronate, a bisphosphonate containing nitrogen (N-BP), is a potent inhibitor of blood stage Plasmodium. Here, we show that P. falciparum parasites overexpressing FPPS/GGPPS are more resistant to risedronate, suggesting that this enzyme is an important target, and bisphosphonate analogues can be used as potential antimalarial drugs. |
| first_indexed | 2024-03-12T18:29:36Z |
| format | Article |
| id | doaj.art-070f78d6ac6e47c78c42ae26b0270cfd |
| institution | Directory Open Access Journal |
| issn | 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T18:29:36Z |
| publishDate | 2018-08-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-070f78d6ac6e47c78c42ae26b0270cfd2023-08-02T08:19:27ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz1678-80602018-08-011131010.1590/0074-02760180174S0074-02762018001000400Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronateHeloisa B GabrielMauro F AzevedoEmília A KimuraAlejandro M KatzinFarnesyl diphosphate synthase/geranylgeranyl diphosphate synthase (FPPS/GGPPS) is a key enzyme in the synthesis of isoprenic chains. Risedronate, a bisphosphonate containing nitrogen (N-BP), is a potent inhibitor of blood stage Plasmodium. Here, we show that P. falciparum parasites overexpressing FPPS/GGPPS are more resistant to risedronate, suggesting that this enzyme is an important target, and bisphosphonate analogues can be used as potential antimalarial drugs.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762018001000400&lng=en&tlng=enP. falciparumFPPS/GGPPSrisedronateoverexpression |
| spellingShingle | Heloisa B Gabriel Mauro F Azevedo Emília A Kimura Alejandro M Katzin Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate Memorias do Instituto Oswaldo Cruz P. falciparum FPPS/GGPPS risedronate overexpression |
| title | Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate |
| title_full | Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate |
| title_fullStr | Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate |
| title_full_unstemmed | Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate |
| title_short | Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate |
| title_sort | plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase geranylgeranyl diphosphate synthase are more resistant to risedronate |
| topic | P. falciparum FPPS/GGPPS risedronate overexpression |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762018001000400&lng=en&tlng=en |
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