Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate
Farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase (FPPS/GGPPS) is a key enzyme in the synthesis of isoprenic chains. Risedronate, a bisphosphonate containing nitrogen (N-BP), is a potent inhibitor of blood stage Plasmodium. Here, we show that P. falciparum parasites overexpressing FP...
| Príomhchruthaitheoirí: | , , , |
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| Formáid: | Alt |
| Teanga: | English |
| Foilsithe / Cruthaithe: |
Fundação Oswaldo Cruz (FIOCRUZ)
2018-08-01
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| Sraith: | Memorias do Instituto Oswaldo Cruz |
| Ábhair: | |
| Rochtain ar líne: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762018001000400&lng=en&tlng=en |