Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate

Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate

Farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase (FPPS/GGPPS) is a key enzyme in the synthesis of isoprenic chains. Risedronate, a bisphosphonate containing nitrogen (N-BP), is a potent inhibitor of blood stage Plasmodium. Here, we show that P. falciparum parasites overexpressing FP...

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Bibliographic Details
Main Authors: Heloisa B Gabriel, Mauro F Azevedo, Emília A Kimura, Alejandro M Katzin
Format: Article
Language:English
Published: Fundação Oswaldo Cruz (FIOCRUZ) 2018-08-01
Series:Memorias do Instituto Oswaldo Cruz
Subjects:
P. falciparum
FPPS/GGPPS
risedronate
overexpression
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762018001000400&lng=en&tlng=en

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