Role of miRNA dysregulation in sepsis
Abstract Background Sepsis is defined as a state of multisystem organ dysfunction secondary to a dysregulated host response to infection and causes millions of deaths worldwide annually. Novel ways to counteract this disease are needed and such tools may be heralded by a detailed understanding of it...
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| Format: | Article |
| Language: | English |
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BMC
2022-08-01
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| Series: | Molecular Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s10020-022-00527-z |
| _version_ | 1798038880918700032 |
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| author | Amanda Formosa Paul Turgeon Claudia C. dos Santos |
| author_facet | Amanda Formosa Paul Turgeon Claudia C. dos Santos |
| author_sort | Amanda Formosa |
| collection | DOAJ |
| description | Abstract Background Sepsis is defined as a state of multisystem organ dysfunction secondary to a dysregulated host response to infection and causes millions of deaths worldwide annually. Novel ways to counteract this disease are needed and such tools may be heralded by a detailed understanding of its molecular pathogenesis. MiRNAs are small RNA molecules that target mRNAs to inhibit or degrade their translation and have important roles in several disease processes including sepsis. Main body The current review adopted a strategic approach to analyzing the widespread literature on the topic of miRNAs and sepsis. A pubmed search of “miRNA or microRNA or small RNA and sepsis not review” up to and including January 2021 led to 1140 manuscripts which were reviewed. Two hundred and thirty-three relevant papers were scrutinized for their content and important themes on the topic were identified and subsequently discussed, including an in-depth look at deregulated miRNAs in sepsis in peripheral blood, myeloid derived suppressor cells and extracellular vesicles. Conclusion Our analysis yielded important observations. Certain miRNAs, namely miR-150 and miR-146a, have consistent directional changes in peripheral blood of septic patients across numerous studies with strong data supporting a role in sepsis pathogenesis. Furthermore, a large body of literature show miRNA signatures of clinical relevance, and lastly, many miRNAs deregulated in sepsis are associated with the process of endothelial dysfunction. This review offers a widespread, up-to-date and detailed discussion of the role of miRNAs in sepsis and is meant to stimulate further work in the field due to the potential of these small miRNAs in prompt diagnostics, prognostication and therapeutic agency. |
| first_indexed | 2024-04-11T21:46:24Z |
| format | Article |
| id | doaj.art-070fb13ee4484e67ae0e90b51fea712c |
| institution | Directory Open Access Journal |
| issn | 1076-1551 1528-3658 |
| language | English |
| last_indexed | 2024-04-11T21:46:24Z |
| publishDate | 2022-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Medicine |
| spelling | doaj.art-070fb13ee4484e67ae0e90b51fea712c2022-12-22T04:01:24ZengBMCMolecular Medicine1076-15511528-36582022-08-0128111610.1186/s10020-022-00527-zRole of miRNA dysregulation in sepsisAmanda Formosa0Paul Turgeon1Claudia C. dos Santos2Interdepartmental Division of Critical Care Medicine, University of TorontoThe Keenan Research Centre for Biomedical Science, St. Michael’s Hospital, Unity Health TorontoInterdepartmental Division of Critical Care Medicine, University of TorontoAbstract Background Sepsis is defined as a state of multisystem organ dysfunction secondary to a dysregulated host response to infection and causes millions of deaths worldwide annually. Novel ways to counteract this disease are needed and such tools may be heralded by a detailed understanding of its molecular pathogenesis. MiRNAs are small RNA molecules that target mRNAs to inhibit or degrade their translation and have important roles in several disease processes including sepsis. Main body The current review adopted a strategic approach to analyzing the widespread literature on the topic of miRNAs and sepsis. A pubmed search of “miRNA or microRNA or small RNA and sepsis not review” up to and including January 2021 led to 1140 manuscripts which were reviewed. Two hundred and thirty-three relevant papers were scrutinized for their content and important themes on the topic were identified and subsequently discussed, including an in-depth look at deregulated miRNAs in sepsis in peripheral blood, myeloid derived suppressor cells and extracellular vesicles. Conclusion Our analysis yielded important observations. Certain miRNAs, namely miR-150 and miR-146a, have consistent directional changes in peripheral blood of septic patients across numerous studies with strong data supporting a role in sepsis pathogenesis. Furthermore, a large body of literature show miRNA signatures of clinical relevance, and lastly, many miRNAs deregulated in sepsis are associated with the process of endothelial dysfunction. This review offers a widespread, up-to-date and detailed discussion of the role of miRNAs in sepsis and is meant to stimulate further work in the field due to the potential of these small miRNAs in prompt diagnostics, prognostication and therapeutic agency.https://doi.org/10.1186/s10020-022-00527-zmiRNAsSmall RNAsSepsisSeptic shockEndotheliumExtracellular vesicles |
| spellingShingle | Amanda Formosa Paul Turgeon Claudia C. dos Santos Role of miRNA dysregulation in sepsis Molecular Medicine miRNAs Small RNAs Sepsis Septic shock Endothelium Extracellular vesicles |
| title | Role of miRNA dysregulation in sepsis |
| title_full | Role of miRNA dysregulation in sepsis |
| title_fullStr | Role of miRNA dysregulation in sepsis |
| title_full_unstemmed | Role of miRNA dysregulation in sepsis |
| title_short | Role of miRNA dysregulation in sepsis |
| title_sort | role of mirna dysregulation in sepsis |
| topic | miRNAs Small RNAs Sepsis Septic shock Endothelium Extracellular vesicles |
| url | https://doi.org/10.1186/s10020-022-00527-z |
| work_keys_str_mv | AT amandaformosa roleofmirnadysregulationinsepsis AT paulturgeon roleofmirnadysregulationinsepsis AT claudiacdossantos roleofmirnadysregulationinsepsis |