Case Report: Vancomycin-Associated Tubulointerstitial Nephritis in Clinical Practice-Case Report and Review of Literature
Nephrotoxicity is one of the major limiting factors for vancomycin use. The most common histological patterns of kidney injury are acute tubulointerstitial nephritis and acute tubular necrosis. Patients who develop acute tubulointerstitial nephritis are prone to develop acute kidney injury with vanc...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.899886/full |
| _version_ | 1828199287420354560 |
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| author | Lakshmi Kannan Rishi Raj |
| author_facet | Lakshmi Kannan Rishi Raj |
| author_sort | Lakshmi Kannan |
| collection | DOAJ |
| description | Nephrotoxicity is one of the major limiting factors for vancomycin use. The most common histological patterns of kidney injury are acute tubulointerstitial nephritis and acute tubular necrosis. Patients who develop acute tubulointerstitial nephritis are prone to develop acute kidney injury with vancomycin rechallenge and, in most cases, present alone or as a part of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS). The purpose of the review study is to identify biopsy-proven vancomycin-associated-tubulointerstitial nephritis in literature, determine possible underlying pathophysiology and identify the consequences of vancomycin rechallenge in such patients. |
| first_indexed | 2024-04-12T10:52:52Z |
| format | Article |
| id | doaj.art-07109e967d4b403bbd3e6630435a19e7 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-12T10:52:52Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-07109e967d4b403bbd3e6630435a19e72022-12-22T03:36:10ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-05-01910.3389/fmed.2022.899886899886Case Report: Vancomycin-Associated Tubulointerstitial Nephritis in Clinical Practice-Case Report and Review of LiteratureLakshmi Kannan0Rishi Raj1Department of Internal Medicine, Division of Nephrology, Pikeville Medical Center, Pikeville, KY, United StatesDepartment of Internal Medicine, Pikeville Medical Center, Pikeville, KY, United StatesNephrotoxicity is one of the major limiting factors for vancomycin use. The most common histological patterns of kidney injury are acute tubulointerstitial nephritis and acute tubular necrosis. Patients who develop acute tubulointerstitial nephritis are prone to develop acute kidney injury with vancomycin rechallenge and, in most cases, present alone or as a part of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS). The purpose of the review study is to identify biopsy-proven vancomycin-associated-tubulointerstitial nephritis in literature, determine possible underlying pathophysiology and identify the consequences of vancomycin rechallenge in such patients.https://www.frontiersin.org/articles/10.3389/fmed.2022.899886/fullvancomycinacute interstitial nephritisnephrotoxicityMRSAkidney biopsy |
| spellingShingle | Lakshmi Kannan Rishi Raj Case Report: Vancomycin-Associated Tubulointerstitial Nephritis in Clinical Practice-Case Report and Review of Literature Frontiers in Medicine vancomycin acute interstitial nephritis nephrotoxicity MRSA kidney biopsy |
| title | Case Report: Vancomycin-Associated Tubulointerstitial Nephritis in Clinical Practice-Case Report and Review of Literature |
| title_full | Case Report: Vancomycin-Associated Tubulointerstitial Nephritis in Clinical Practice-Case Report and Review of Literature |
| title_fullStr | Case Report: Vancomycin-Associated Tubulointerstitial Nephritis in Clinical Practice-Case Report and Review of Literature |
| title_full_unstemmed | Case Report: Vancomycin-Associated Tubulointerstitial Nephritis in Clinical Practice-Case Report and Review of Literature |
| title_short | Case Report: Vancomycin-Associated Tubulointerstitial Nephritis in Clinical Practice-Case Report and Review of Literature |
| title_sort | case report vancomycin associated tubulointerstitial nephritis in clinical practice case report and review of literature |
| topic | vancomycin acute interstitial nephritis nephrotoxicity MRSA kidney biopsy |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.899886/full |
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