Effects of postoperative nebulized furosemide and budesonide on postoperative sore throat in patients undergoing maxillofacial surgery: A randomized controlled trial
Purpose: Postoperative sore throat (POST) is a common complication. We compared postoperative nebulized furosemide, budesonide, and sodium chloride solution for POST in patients undergoing maxillofacial surgery. Methods: 75 patients were randomly divided into 3 groups. Anesthesia induction and intub...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | Advances in Oral and Maxillofacial Surgery |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667147622001273 |
| _version_ | 1797903287604740096 |
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| author | Jie An Lei Wang Yuan Chen Dong Yang Yan Huang |
| author_facet | Jie An Lei Wang Yuan Chen Dong Yang Yan Huang |
| author_sort | Jie An |
| collection | DOAJ |
| description | Purpose: Postoperative sore throat (POST) is a common complication. We compared postoperative nebulized furosemide, budesonide, and sodium chloride solution for POST in patients undergoing maxillofacial surgery. Methods: 75 patients were randomly divided into 3 groups. Anesthesia induction and intubation were routinely performed. Following emergence, the patients were randomized to one of three groups. Group F was treated with 40mg of aerosolized furosemide, group B received 2 mg of aerosolized budesonide and Group S was given aerosolized 0.9% sodium chloride solution. Patients were assessed for sore throat,hoarseness, foreign body sensation,dry mouth, cough，nausea and vomiting at 15 min, 1, 2, 4, 6, 8, 12, 24 and 48 h after extubation. Results: Patients all in three groups had comparable clinical and surgical data.Compared to Group S, POST at rest and during swallowing was significantly lower in Group F and Group B at 2, 4, 6, 8 and 12 h (P < 0.05).Compared to Group S, the incidence of postoperative hoarseness was significantly lower in Group F at 1,2,4,6,8,12 h (P < 0.05)and significantly lower in Group B at 6 h and 8 h (P < 0.05). In particular, the incidence of hoarseness at 1,2,4,24 h in group F was significantly lower than that in group B (P < 0.05). In terms of foreign body sensation, group F was significantly lower than group S at 4 h and 6 h(P < 0.05). Conclusions: Postoperative nebulization of furosemide or budesonide are effective ways to reduce the severity of POST. Nebulized furosemide has more advantages in reducing postoperative hoarseness. |
| first_indexed | 2024-04-10T09:30:30Z |
| format | Article |
| id | doaj.art-07120bd00e2947c68bbf8c5101e1cc21 |
| institution | Directory Open Access Journal |
| issn | 2667-1476 |
| language | English |
| last_indexed | 2024-04-10T09:30:30Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Advances in Oral and Maxillofacial Surgery |
| spelling | doaj.art-07120bd00e2947c68bbf8c5101e1cc212023-02-19T04:27:39ZengElsevierAdvances in Oral and Maxillofacial Surgery2667-14762023-03-019100377Effects of postoperative nebulized furosemide and budesonide on postoperative sore throat in patients undergoing maxillofacial surgery: A randomized controlled trialJie An0Lei Wang1Yuan Chen2Dong Yang3Yan Huang4Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 33 Badachu Road, Shijingshan District, Beijing, ChinaDepartment of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 33 Badachu Road, Shijingshan District, Beijing, ChinaDepartment of Postanesthesia Care Unit(PACU), Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 33 Badachu Road, Shijingshan District, Beijing, ChinaDepartment of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 33 Badachu Road, Shijingshan District, Beijing, China; Corresponding author.Department of Postanesthesia Care Unit(PACU), Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 33 Badachu Road, Shijingshan District, Beijing, ChinaPurpose: Postoperative sore throat (POST) is a common complication. We compared postoperative nebulized furosemide, budesonide, and sodium chloride solution for POST in patients undergoing maxillofacial surgery. Methods: 75 patients were randomly divided into 3 groups. Anesthesia induction and intubation were routinely performed. Following emergence, the patients were randomized to one of three groups. Group F was treated with 40mg of aerosolized furosemide, group B received 2 mg of aerosolized budesonide and Group S was given aerosolized 0.9% sodium chloride solution. Patients were assessed for sore throat,hoarseness, foreign body sensation,dry mouth, cough，nausea and vomiting at 15 min, 1, 2, 4, 6, 8, 12, 24 and 48 h after extubation. Results: Patients all in three groups had comparable clinical and surgical data.Compared to Group S, POST at rest and during swallowing was significantly lower in Group F and Group B at 2, 4, 6, 8 and 12 h (P < 0.05).Compared to Group S, the incidence of postoperative hoarseness was significantly lower in Group F at 1,2,4,6,8,12 h (P < 0.05)and significantly lower in Group B at 6 h and 8 h (P < 0.05). In particular, the incidence of hoarseness at 1,2,4,24 h in group F was significantly lower than that in group B (P < 0.05). In terms of foreign body sensation, group F was significantly lower than group S at 4 h and 6 h(P < 0.05). Conclusions: Postoperative nebulization of furosemide or budesonide are effective ways to reduce the severity of POST. Nebulized furosemide has more advantages in reducing postoperative hoarseness.http://www.sciencedirect.com/science/article/pii/S2667147622001273Postoperative sore throatFurosemideBudesonideMaxillofacial surgeryNebulization |
| spellingShingle | Jie An Lei Wang Yuan Chen Dong Yang Yan Huang Effects of postoperative nebulized furosemide and budesonide on postoperative sore throat in patients undergoing maxillofacial surgery: A randomized controlled trial Advances in Oral and Maxillofacial Surgery Postoperative sore throat Furosemide Budesonide Maxillofacial surgery Nebulization |
| title | Effects of postoperative nebulized furosemide and budesonide on postoperative sore throat in patients undergoing maxillofacial surgery: A randomized controlled trial |
| title_full | Effects of postoperative nebulized furosemide and budesonide on postoperative sore throat in patients undergoing maxillofacial surgery: A randomized controlled trial |
| title_fullStr | Effects of postoperative nebulized furosemide and budesonide on postoperative sore throat in patients undergoing maxillofacial surgery: A randomized controlled trial |
| title_full_unstemmed | Effects of postoperative nebulized furosemide and budesonide on postoperative sore throat in patients undergoing maxillofacial surgery: A randomized controlled trial |
| title_short | Effects of postoperative nebulized furosemide and budesonide on postoperative sore throat in patients undergoing maxillofacial surgery: A randomized controlled trial |
| title_sort | effects of postoperative nebulized furosemide and budesonide on postoperative sore throat in patients undergoing maxillofacial surgery a randomized controlled trial |
| topic | Postoperative sore throat Furosemide Budesonide Maxillofacial surgery Nebulization |
| url | http://www.sciencedirect.com/science/article/pii/S2667147622001273 |
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