Effects of Psychostimulant Drugs on Developing Brain

Although psychostimulants have been used for the treatment of attention deficit hyperactivity disorder for approximately 70 years, little is known about the long term effects of these drugs on developing brain. The observable effects of psychostimulants are influenced by the timing of exposure, the...

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Main Authors: Ibrahim Durukan, Murat Erdem, Koray Kara, Dursun Karaman
Format: Article
Language:English
Published: Psikiyatride Güncel Yaklaşımlar 2013-08-01
Series:Psikiyatride Güncel Yaklaşımlar
Subjects:
Online Access:http://www.scopemed.org/fulltextpdf.php?mno=32051
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author Ibrahim Durukan
Murat Erdem
Koray Kara
Dursun Karaman
author_facet Ibrahim Durukan
Murat Erdem
Koray Kara
Dursun Karaman
author_sort Ibrahim Durukan
collection DOAJ
description Although psychostimulants have been used for the treatment of attention deficit hyperactivity disorder for approximately 70 years, little is known about the long term effects of these drugs on developing brain. The observable effects of psychostimulants are influenced by the timing of exposure, the age of examination after drug exposure and sex. Preclinical studies point out that chronic psychostimulant exposure before adolescence cause reverse sensitization or tolerance and this leads to reduction in stimulant effectiveness in adolesecence and adulthood. Preclinical studies show the potential long term effects of psychostimulants. But it is necessary to investigate the relationship between preclinical effects and clinical practice. A developmental approach is needed to understand the impact of pediatric medications on the brain that includes assessment at multiple ages to completely characterize the long term effects of these medications. The aim of this paper is to review the effects of psychostimulants on developing brain.
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spelling doaj.art-071403497fad425c81de5551a73f864b2024-02-03T05:25:54ZengPsikiyatride Güncel YaklaşımlarPsikiyatride Güncel Yaklaşımlar1309-06582013-08-015452853910.5455/cap.2013053232051Effects of Psychostimulant Drugs on Developing BrainIbrahim Durukan0Murat Erdem1Koray Kara2Dursun Karaman3GATA Cocuk ve Ergen Ruh Sagligi ve Hst. AD: GATA Ruh Sagligi ve Hst. AD GATA Cocuk ve Ergen Ruh Sagligi ve Hst. AD: GATA Cocuk ve Ergen Ruh Sagligi ve Hst. AD:Although psychostimulants have been used for the treatment of attention deficit hyperactivity disorder for approximately 70 years, little is known about the long term effects of these drugs on developing brain. The observable effects of psychostimulants are influenced by the timing of exposure, the age of examination after drug exposure and sex. Preclinical studies point out that chronic psychostimulant exposure before adolescence cause reverse sensitization or tolerance and this leads to reduction in stimulant effectiveness in adolesecence and adulthood. Preclinical studies show the potential long term effects of psychostimulants. But it is necessary to investigate the relationship between preclinical effects and clinical practice. A developmental approach is needed to understand the impact of pediatric medications on the brain that includes assessment at multiple ages to completely characterize the long term effects of these medications. The aim of this paper is to review the effects of psychostimulants on developing brain.http://www.scopemed.org/fulltextpdf.php?mno=32051Psychostimulantdeveloping brainattention deficit hyperactivity disorder
spellingShingle Ibrahim Durukan
Murat Erdem
Koray Kara
Dursun Karaman
Effects of Psychostimulant Drugs on Developing Brain
Psikiyatride Güncel Yaklaşımlar
Psychostimulant
developing brain
attention deficit hyperactivity disorder
title Effects of Psychostimulant Drugs on Developing Brain
title_full Effects of Psychostimulant Drugs on Developing Brain
title_fullStr Effects of Psychostimulant Drugs on Developing Brain
title_full_unstemmed Effects of Psychostimulant Drugs on Developing Brain
title_short Effects of Psychostimulant Drugs on Developing Brain
title_sort effects of psychostimulant drugs on developing brain
topic Psychostimulant
developing brain
attention deficit hyperactivity disorder
url http://www.scopemed.org/fulltextpdf.php?mno=32051
work_keys_str_mv AT ibrahimdurukan effectsofpsychostimulantdrugsondevelopingbrain
AT muraterdem effectsofpsychostimulantdrugsondevelopingbrain
AT koraykara effectsofpsychostimulantdrugsondevelopingbrain
AT dursunkaraman effectsofpsychostimulantdrugsondevelopingbrain