MEFV gene mutations in neuro‐Behçet's disease and neuro‐Sweet disease
Abstract Mediterranean fever (MEFV) gene mutations are associated with familial Mediterranean fever (FMF). Recent studies have suggested that MEFV gene mutations may act as disease modifiers in neuro‐Behçet's (NBD) disease and neuro‐Sweet disease (NSD). We investigated MEFV genes and clinical f...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-12-01
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| Series: | Annals of Clinical and Translational Neurology |
| Online Access: | https://doi.org/10.1002/acn3.50937 |
| _version_ | 1818461885967630336 |
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| author | Hidehiro Ishikawa Akihiro Shindo Yuichiro Ii Dai Kishida Atsushi Niwa Yamato Nishiguchi Keita Matsuura Natsuko Kato Akane Mizutani Kei Tachibana Yoshinori Hirata Hirofumi Matsuyama Ai Ogawa‐Ito Akira Taniguchi Hidekazu Tomimoto |
| author_facet | Hidehiro Ishikawa Akihiro Shindo Yuichiro Ii Dai Kishida Atsushi Niwa Yamato Nishiguchi Keita Matsuura Natsuko Kato Akane Mizutani Kei Tachibana Yoshinori Hirata Hirofumi Matsuyama Ai Ogawa‐Ito Akira Taniguchi Hidekazu Tomimoto |
| author_sort | Hidehiro Ishikawa |
| collection | DOAJ |
| description | Abstract Mediterranean fever (MEFV) gene mutations are associated with familial Mediterranean fever (FMF). Recent studies have suggested that MEFV gene mutations may act as disease modifiers in neuro‐Behçet's (NBD) disease and neuro‐Sweet disease (NSD). We investigated MEFV genes and clinical features in 17 patients with NBD or NSD. MEFV gene mutations were frequently observed (70.6%). Headaches and exertional leg pain were associated with MEFV gene mutations (P < 0.05). Moreover, higher frequency of white matter lesions without sites predilection (P < 0.05) and non‐parenchymal lesions (P < 0.05) were also observed. MEFV gene mutations may be associated with particular findings and lesion sites. |
| first_indexed | 2024-12-14T23:53:15Z |
| format | Article |
| id | doaj.art-07142c8911924b4ab0967f18a015d68e |
| institution | Directory Open Access Journal |
| issn | 2328-9503 |
| language | English |
| last_indexed | 2024-12-14T23:53:15Z |
| publishDate | 2019-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Clinical and Translational Neurology |
| spelling | doaj.art-07142c8911924b4ab0967f18a015d68e2022-12-21T22:43:10ZengWileyAnnals of Clinical and Translational Neurology2328-95032019-12-016122595260010.1002/acn3.50937MEFV gene mutations in neuro‐Behçet's disease and neuro‐Sweet diseaseHidehiro Ishikawa0Akihiro Shindo1Yuichiro Ii2Dai Kishida3Atsushi Niwa4Yamato Nishiguchi5Keita Matsuura6Natsuko Kato7Akane Mizutani8Kei Tachibana9Yoshinori Hirata10Hirofumi Matsuyama11Ai Ogawa‐Ito12Akira Taniguchi13Hidekazu Tomimoto14Department of Neurology Mie University Graduate School of Medicine Mie JapanDepartment of Neurology Mie University Graduate School of Medicine Mie JapanDepartment of Neurology Mie University Graduate School of Medicine Mie JapanDepartment of Medicine (Neurology and Rheumatology) Shinshu University School of Medicine Nagano JapanDepartment of Neurology Mie University Graduate School of Medicine Mie JapanDepartment of Neurology Mie University Graduate School of Medicine Mie JapanDepartment of Neurology Mie University Graduate School of Medicine Mie JapanDepartment of Neurology Mie University Graduate School of Medicine Mie JapanDepartment of Neurology Mie University Graduate School of Medicine Mie JapanDepartment of Neurology Mie University Graduate School of Medicine Mie JapanDepartment of Neurology Mie University Graduate School of Medicine Mie JapanDepartment of Neurology Mie University Graduate School of Medicine Mie JapanDepartment of Neurology Mie University Graduate School of Medicine Mie JapanDepartment of Neurology Mie University Graduate School of Medicine Mie JapanDepartment of Neurology Mie University Graduate School of Medicine Mie JapanAbstract Mediterranean fever (MEFV) gene mutations are associated with familial Mediterranean fever (FMF). Recent studies have suggested that MEFV gene mutations may act as disease modifiers in neuro‐Behçet's (NBD) disease and neuro‐Sweet disease (NSD). We investigated MEFV genes and clinical features in 17 patients with NBD or NSD. MEFV gene mutations were frequently observed (70.6%). Headaches and exertional leg pain were associated with MEFV gene mutations (P < 0.05). Moreover, higher frequency of white matter lesions without sites predilection (P < 0.05) and non‐parenchymal lesions (P < 0.05) were also observed. MEFV gene mutations may be associated with particular findings and lesion sites.https://doi.org/10.1002/acn3.50937 |
| spellingShingle | Hidehiro Ishikawa Akihiro Shindo Yuichiro Ii Dai Kishida Atsushi Niwa Yamato Nishiguchi Keita Matsuura Natsuko Kato Akane Mizutani Kei Tachibana Yoshinori Hirata Hirofumi Matsuyama Ai Ogawa‐Ito Akira Taniguchi Hidekazu Tomimoto MEFV gene mutations in neuro‐Behçet's disease and neuro‐Sweet disease Annals of Clinical and Translational Neurology |
| title | MEFV gene mutations in neuro‐Behçet's disease and neuro‐Sweet disease |
| title_full | MEFV gene mutations in neuro‐Behçet's disease and neuro‐Sweet disease |
| title_fullStr | MEFV gene mutations in neuro‐Behçet's disease and neuro‐Sweet disease |
| title_full_unstemmed | MEFV gene mutations in neuro‐Behçet's disease and neuro‐Sweet disease |
| title_short | MEFV gene mutations in neuro‐Behçet's disease and neuro‐Sweet disease |
| title_sort | mefv gene mutations in neuro behcet s disease and neuro sweet disease |
| url | https://doi.org/10.1002/acn3.50937 |
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