CD13 regulation of membrane recycling: implications for cancer dissemination
Membrane recycling is critical to numerous cell functions and its dysregulation contributes to cancer and metastasis. We established that activation of the transmembrane molecule aminopeptidase N (ANPEP, also known as CD13) tethers the IQ motif containing, guanosine triphosphate hydrolase activating...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2019-11-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2019.1648024 |
| _version_ | 1797677121637711872 |
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| author | Mallika Ghosh Linda H. Shapiro |
| author_facet | Mallika Ghosh Linda H. Shapiro |
| author_sort | Mallika Ghosh |
| collection | DOAJ |
| description | Membrane recycling is critical to numerous cell functions and its dysregulation contributes to cancer and metastasis. We established that activation of the transmembrane molecule aminopeptidase N (ANPEP, also known as CD13) tethers the IQ motif containing, guanosine triphosphate hydrolase activating protein 1 (IQGAP1) scaffolding protein at the plasma membrane, thus stimulating the recycling regulator ADP-ribosylation factor 6 (ARF6) to ensure proper recycling of β1-integrin and other membrane components impacting cell attachment. |
| first_indexed | 2024-03-11T22:40:24Z |
| format | Article |
| id | doaj.art-0716a4531e8f46c881bd716702bb2b6c |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:40:24Z |
| publishDate | 2019-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-0716a4531e8f46c881bd716702bb2b6c2023-09-22T09:11:01ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562019-11-016610.1080/23723556.2019.16480241648024CD13 regulation of membrane recycling: implications for cancer disseminationMallika Ghosh0Linda H. Shapiro1University of Connecticut School of MedicineUniversity of Connecticut School of MedicineMembrane recycling is critical to numerous cell functions and its dysregulation contributes to cancer and metastasis. We established that activation of the transmembrane molecule aminopeptidase N (ANPEP, also known as CD13) tethers the IQ motif containing, guanosine triphosphate hydrolase activating protein 1 (IQGAP1) scaffolding protein at the plasma membrane, thus stimulating the recycling regulator ADP-ribosylation factor 6 (ARF6) to ensure proper recycling of β1-integrin and other membrane components impacting cell attachment.http://dx.doi.org/10.1080/23723556.2019.1648024cd13anpepmembrane recyclingendocytosis |
| spellingShingle | Mallika Ghosh Linda H. Shapiro CD13 regulation of membrane recycling: implications for cancer dissemination Molecular & Cellular Oncology cd13 anpep membrane recycling endocytosis |
| title | CD13 regulation of membrane recycling: implications for cancer dissemination |
| title_full | CD13 regulation of membrane recycling: implications for cancer dissemination |
| title_fullStr | CD13 regulation of membrane recycling: implications for cancer dissemination |
| title_full_unstemmed | CD13 regulation of membrane recycling: implications for cancer dissemination |
| title_short | CD13 regulation of membrane recycling: implications for cancer dissemination |
| title_sort | cd13 regulation of membrane recycling implications for cancer dissemination |
| topic | cd13 anpep membrane recycling endocytosis |
| url | http://dx.doi.org/10.1080/23723556.2019.1648024 |
| work_keys_str_mv | AT mallikaghosh cd13regulationofmembranerecyclingimplicationsforcancerdissemination AT lindahshapiro cd13regulationofmembranerecyclingimplicationsforcancerdissemination |