Long noncoding RNAs as therapeutic targets to overcome chemoresistance in ovarian cancer
Long noncoding RNAs (lncRNAs) have been characterized to play an essential role in ovarian tumorigenesis via controlling a variety of cellular processes, such as cell proliferation, invasion, apoptotic death, metastasis, cell cycle, migration, metabolism, immune evasion, and chemoresistance. The one...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.999174/full |
| _version_ | 1798036346410893312 |
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| author | Linjiao Chen Jie Wang Qian Liu |
| author_facet | Linjiao Chen Jie Wang Qian Liu |
| author_sort | Linjiao Chen |
| collection | DOAJ |
| description | Long noncoding RNAs (lncRNAs) have been characterized to play an essential role in ovarian tumorigenesis via controlling a variety of cellular processes, such as cell proliferation, invasion, apoptotic death, metastasis, cell cycle, migration, metabolism, immune evasion, and chemoresistance. The one obstacle for the therapeutic efficacy is due to the development of drug resistance in ovarian cancer patients. Therefore, in this review article, we describe the role of lncRNAs in chemoresistance in ovarian cancer. Moreover, we discuss the molecular mechanism of lncRNAs-involved drug resistance in ovarian cancer. We conclude that lncRNAs could be useful targets to overcome chemoresistance and improve therapeutic outcome in ovarian cancer patients. |
| first_indexed | 2024-04-11T21:10:32Z |
| format | Article |
| id | doaj.art-07173660c7a34a2890de97369ee64238 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-11T21:10:32Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-07173660c7a34a2890de97369ee642382022-12-22T04:03:01ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-08-011010.3389/fcell.2022.999174999174Long noncoding RNAs as therapeutic targets to overcome chemoresistance in ovarian cancerLinjiao ChenJie WangQian LiuLong noncoding RNAs (lncRNAs) have been characterized to play an essential role in ovarian tumorigenesis via controlling a variety of cellular processes, such as cell proliferation, invasion, apoptotic death, metastasis, cell cycle, migration, metabolism, immune evasion, and chemoresistance. The one obstacle for the therapeutic efficacy is due to the development of drug resistance in ovarian cancer patients. Therefore, in this review article, we describe the role of lncRNAs in chemoresistance in ovarian cancer. Moreover, we discuss the molecular mechanism of lncRNAs-involved drug resistance in ovarian cancer. We conclude that lncRNAs could be useful targets to overcome chemoresistance and improve therapeutic outcome in ovarian cancer patients.https://www.frontiersin.org/articles/10.3389/fcell.2022.999174/fulllncRNAepigeneticchemoresistanceovarian cancercisplatinpaclitaxel |
| spellingShingle | Linjiao Chen Jie Wang Qian Liu Long noncoding RNAs as therapeutic targets to overcome chemoresistance in ovarian cancer Frontiers in Cell and Developmental Biology lncRNA epigenetic chemoresistance ovarian cancer cisplatin paclitaxel |
| title | Long noncoding RNAs as therapeutic targets to overcome chemoresistance in ovarian cancer |
| title_full | Long noncoding RNAs as therapeutic targets to overcome chemoresistance in ovarian cancer |
| title_fullStr | Long noncoding RNAs as therapeutic targets to overcome chemoresistance in ovarian cancer |
| title_full_unstemmed | Long noncoding RNAs as therapeutic targets to overcome chemoresistance in ovarian cancer |
| title_short | Long noncoding RNAs as therapeutic targets to overcome chemoresistance in ovarian cancer |
| title_sort | long noncoding rnas as therapeutic targets to overcome chemoresistance in ovarian cancer |
| topic | lncRNA epigenetic chemoresistance ovarian cancer cisplatin paclitaxel |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.999174/full |
| work_keys_str_mv | AT linjiaochen longnoncodingrnasastherapeutictargetstoovercomechemoresistanceinovariancancer AT jiewang longnoncodingrnasastherapeutictargetstoovercomechemoresistanceinovariancancer AT qianliu longnoncodingrnasastherapeutictargetstoovercomechemoresistanceinovariancancer |