Awareness, perception, and barriers of healthcare providers toward the revised consensus guideline for therapeutic monitoring of vancomycin
Background: A revised consensus guideline published in 2020 recommended transitioning vancomycin monitoring to the area under the concentration–time curve over 24 h to minimum inhibitory concentration (AUC24/MIC). The decision to transition to AUC24/MIC monitoring or to continue trough-based monitor...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Saudi Pharmaceutical Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1319016423001147 |
| _version_ | 1797813705976578048 |
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| author | Sarah S. Alghanem Abdullah Albassam Nwayer Al-Rashidi Zainab Bin Haidar |
| author_facet | Sarah S. Alghanem Abdullah Albassam Nwayer Al-Rashidi Zainab Bin Haidar |
| author_sort | Sarah S. Alghanem |
| collection | DOAJ |
| description | Background: A revised consensus guideline published in 2020 recommended transitioning vancomycin monitoring to the area under the concentration–time curve over 24 h to minimum inhibitory concentration (AUC24/MIC). The decision to transition to AUC24/MIC monitoring or to continue trough-based monitoring is made at the institutional level and is influenced by several factors, including healthcare providers and system-related factors. Changing current practices is expected to be difficult, and it is important to understand healthcare providers’ perceptions and potential barriers before the transition. This study assessed the awareness and perception of physicians and pharmacists toward the revised guideline and identified barriers to their implementation in Kuwait. Methods: A cross-sectional survey that employed a self-administered questionnaire was used. A random sample of physicians (n = 390), clinical microbiologists (n = 37), and clinical pharmacists (n = 48) across six Kuwaiti public hospitals were surveyed. Descriptive and comparative statistical analyses were performed. Factors associated with awareness and perceptions among the participants were identified. Results: The response rate was 85.3% (n = 431). Participants had a high (median = 75%) awareness score for the updated vancomycin guideline, as well as a positive perception (median = 5). The main factor identified to affect the awareness and perception of participants following the group analysis was the years of experience. The main barriers identified were a lack of training to perform vancomycin AUC24 calculations, a lack of accurate documentation sample time, and a long turnaround time for serum levels, which might hinder the implementation of the updated guideline. Conclusion: Physicians, clinical microbiologists, and pharmacists working in Kuwait public hospitals were aware of the 2020 vancomycin monitoring guidelines with positive perceptions. Participants agreed on the several barriers to transitioning to the AUC24/MIC approach, which should be considered by stakeholders before implementation. |
| first_indexed | 2024-03-13T07:56:43Z |
| format | Article |
| id | doaj.art-0719ba08691444f093d4fa8b9783de21 |
| institution | Directory Open Access Journal |
| issn | 1319-0164 |
| language | English |
| last_indexed | 2024-03-13T07:56:43Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Saudi Pharmaceutical Journal |
| spelling | doaj.art-0719ba08691444f093d4fa8b9783de212023-06-02T04:22:50ZengElsevierSaudi Pharmaceutical Journal1319-01642023-06-01316955961Awareness, perception, and barriers of healthcare providers toward the revised consensus guideline for therapeutic monitoring of vancomycinSarah S. Alghanem0Abdullah Albassam1Nwayer Al-Rashidi2Zainab Bin Haidar3Department of Pharmacy Practice, College of Pharmacy, Kuwait University, Safat 13110, Kuwait; Corresponding author at: Department of Pharmacy Practice, College of Pharmacy at Kuwait University, PO Box 24923, Safat 13110, Kuwait.Department of Pharmacy Practice, College of Pharmacy, Kuwait University, Safat 13110, KuwaitDepartment of Pharmacy, Alfarwania Hospital, Ministry of Health, KuwaitDepartment of Pharmacy, Amiri Hospital, Ministry of Health, KuwaitBackground: A revised consensus guideline published in 2020 recommended transitioning vancomycin monitoring to the area under the concentration–time curve over 24 h to minimum inhibitory concentration (AUC24/MIC). The decision to transition to AUC24/MIC monitoring or to continue trough-based monitoring is made at the institutional level and is influenced by several factors, including healthcare providers and system-related factors. Changing current practices is expected to be difficult, and it is important to understand healthcare providers’ perceptions and potential barriers before the transition. This study assessed the awareness and perception of physicians and pharmacists toward the revised guideline and identified barriers to their implementation in Kuwait. Methods: A cross-sectional survey that employed a self-administered questionnaire was used. A random sample of physicians (n = 390), clinical microbiologists (n = 37), and clinical pharmacists (n = 48) across six Kuwaiti public hospitals were surveyed. Descriptive and comparative statistical analyses were performed. Factors associated with awareness and perceptions among the participants were identified. Results: The response rate was 85.3% (n = 431). Participants had a high (median = 75%) awareness score for the updated vancomycin guideline, as well as a positive perception (median = 5). The main factor identified to affect the awareness and perception of participants following the group analysis was the years of experience. The main barriers identified were a lack of training to perform vancomycin AUC24 calculations, a lack of accurate documentation sample time, and a long turnaround time for serum levels, which might hinder the implementation of the updated guideline. Conclusion: Physicians, clinical microbiologists, and pharmacists working in Kuwait public hospitals were aware of the 2020 vancomycin monitoring guidelines with positive perceptions. Participants agreed on the several barriers to transitioning to the AUC24/MIC approach, which should be considered by stakeholders before implementation.http://www.sciencedirect.com/science/article/pii/S1319016423001147Area under the curve over 24 h (AUC24) monitoringTherapeutic drug monitoringTrough monitoringBarriersGlycopeptides |
| spellingShingle | Sarah S. Alghanem Abdullah Albassam Nwayer Al-Rashidi Zainab Bin Haidar Awareness, perception, and barriers of healthcare providers toward the revised consensus guideline for therapeutic monitoring of vancomycin Saudi Pharmaceutical Journal Area under the curve over 24 h (AUC24) monitoring Therapeutic drug monitoring Trough monitoring Barriers Glycopeptides |
| title | Awareness, perception, and barriers of healthcare providers toward the revised consensus guideline for therapeutic monitoring of vancomycin |
| title_full | Awareness, perception, and barriers of healthcare providers toward the revised consensus guideline for therapeutic monitoring of vancomycin |
| title_fullStr | Awareness, perception, and barriers of healthcare providers toward the revised consensus guideline for therapeutic monitoring of vancomycin |
| title_full_unstemmed | Awareness, perception, and barriers of healthcare providers toward the revised consensus guideline for therapeutic monitoring of vancomycin |
| title_short | Awareness, perception, and barriers of healthcare providers toward the revised consensus guideline for therapeutic monitoring of vancomycin |
| title_sort | awareness perception and barriers of healthcare providers toward the revised consensus guideline for therapeutic monitoring of vancomycin |
| topic | Area under the curve over 24 h (AUC24) monitoring Therapeutic drug monitoring Trough monitoring Barriers Glycopeptides |
| url | http://www.sciencedirect.com/science/article/pii/S1319016423001147 |
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