Computational identification and clinical validation of a novel risk signature based on coagulation-related lncRNAs for predicting prognosis, immunotherapy response, and chemosensitivity in colorectal cancer patients

Computational identification and clinical validation of a novel risk signature based on coagulation-related lncRNAs for predicting prognosis, immunotherapy response, and chemosensitivity in colorectal cancer patients

BackgroundCoagulation is critically involved in the tumor microenvironment, cancer progression, and prognosis assessment. Nevertheless, the roles of coagulation-related long noncoding RNAs (CRLs) in colorectal cancer (CRC) remain unclear. In this study, an integrated computational framework was cons...

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Bibliographic Details
Main Authors: Fang Zhang, Rixin Zhang, Jinbao Zong, Yufang Hou, Mingxuan Zhou, Zheng Yan, Tiegang Li, Wenqiang Gan, Silin Lv, Liu Yang, Zifan Zeng, Wenyi Zhao, Min Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Immunology
Subjects:
colorectal cancer
coagulation
long noncoding RNA
prognostic signature
tumor microenvironment
immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1279789/full

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