Lactate metabolism in human health and disease
Abstract The current understanding of lactate extends from its origins as a byproduct of glycolysis to its role in tumor metabolism, as identified by studies on the Warburg effect. The lactate shuttle hypothesis suggests that lactate plays an important role as a bridging signaling molecule that coor...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2022-09-01
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| Series: | Signal Transduction and Targeted Therapy |
| Online Access: | https://doi.org/10.1038/s41392-022-01151-3 |
| _version_ | 1828272368223518720 |
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| author | Xiaolu Li Yanyan Yang Bei Zhang Xiaotong Lin Xiuxiu Fu Yi An Yulin Zou Jian-Xun Wang Zhibin Wang Tao Yu |
| author_facet | Xiaolu Li Yanyan Yang Bei Zhang Xiaotong Lin Xiuxiu Fu Yi An Yulin Zou Jian-Xun Wang Zhibin Wang Tao Yu |
| author_sort | Xiaolu Li |
| collection | DOAJ |
| description | Abstract The current understanding of lactate extends from its origins as a byproduct of glycolysis to its role in tumor metabolism, as identified by studies on the Warburg effect. The lactate shuttle hypothesis suggests that lactate plays an important role as a bridging signaling molecule that coordinates signaling among different cells, organs and tissues. Lactylation is a posttranslational modification initially reported by Professor Yingming Zhao’s research group in 2019. Subsequent studies confirmed that lactylation is a vital component of lactate function and is involved in tumor proliferation, neural excitation, inflammation and other biological processes. An indispensable substance for various physiological cellular functions, lactate plays a regulatory role in different aspects of energy metabolism and signal transduction. Therefore, a comprehensive review and summary of lactate is presented to clarify the role of lactate in disease and to provide a reference and direction for future research. This review offers a systematic overview of lactate homeostasis and its roles in physiological and pathological processes, as well as a comprehensive overview of the effects of lactylation in various diseases, particularly inflammation and cancer. |
| first_indexed | 2024-04-13T06:05:43Z |
| format | Article |
| id | doaj.art-071c8b615baf410fa162019d500c0e1f |
| institution | Directory Open Access Journal |
| issn | 2059-3635 |
| language | English |
| last_indexed | 2024-04-13T06:05:43Z |
| publishDate | 2022-09-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Signal Transduction and Targeted Therapy |
| spelling | doaj.art-071c8b615baf410fa162019d500c0e1f2022-12-22T02:59:16ZengNature Publishing GroupSignal Transduction and Targeted Therapy2059-36352022-09-017112210.1038/s41392-022-01151-3Lactate metabolism in human health and diseaseXiaolu Li0Yanyan Yang1Bei Zhang2Xiaotong Lin3Xiuxiu Fu4Yi An5Yulin Zou6Jian-Xun Wang7Zhibin Wang8Tao Yu9Center for Regenerative Medicine, Institute for Translational Medicine, The Affiliated Hospital of Qingdao University; Department of Cardiac Ultrasound, The Affiliated Hospital of Qingdao UniversityDepartment of Immunology, School of Basic Medicine, Qingdao UniversityDepartment of Immunology, School of Basic Medicine, Qingdao UniversityDepartment of Respiratory Medicine, Qingdao Municipal HospitalDepartment of Cardiac Ultrasound, The Affiliated Hospital of Qingdao UniversityDepartment of Cardiology, The Affiliated Hospital of Qingdao UniversityDepartment of Cardiac Ultrasound, The Affiliated Hospital of Qingdao UniversityDepartment of Immunology, School of Basic Medicine, Qingdao UniversityDepartment of Cardiac Ultrasound, The Affiliated Hospital of Qingdao UniversityCenter for Regenerative Medicine, Institute for Translational Medicine, The Affiliated Hospital of Qingdao University; Department of Cardiac Ultrasound, The Affiliated Hospital of Qingdao UniversityAbstract The current understanding of lactate extends from its origins as a byproduct of glycolysis to its role in tumor metabolism, as identified by studies on the Warburg effect. The lactate shuttle hypothesis suggests that lactate plays an important role as a bridging signaling molecule that coordinates signaling among different cells, organs and tissues. Lactylation is a posttranslational modification initially reported by Professor Yingming Zhao’s research group in 2019. Subsequent studies confirmed that lactylation is a vital component of lactate function and is involved in tumor proliferation, neural excitation, inflammation and other biological processes. An indispensable substance for various physiological cellular functions, lactate plays a regulatory role in different aspects of energy metabolism and signal transduction. Therefore, a comprehensive review and summary of lactate is presented to clarify the role of lactate in disease and to provide a reference and direction for future research. This review offers a systematic overview of lactate homeostasis and its roles in physiological and pathological processes, as well as a comprehensive overview of the effects of lactylation in various diseases, particularly inflammation and cancer.https://doi.org/10.1038/s41392-022-01151-3 |
| spellingShingle | Xiaolu Li Yanyan Yang Bei Zhang Xiaotong Lin Xiuxiu Fu Yi An Yulin Zou Jian-Xun Wang Zhibin Wang Tao Yu Lactate metabolism in human health and disease Signal Transduction and Targeted Therapy |
| title | Lactate metabolism in human health and disease |
| title_full | Lactate metabolism in human health and disease |
| title_fullStr | Lactate metabolism in human health and disease |
| title_full_unstemmed | Lactate metabolism in human health and disease |
| title_short | Lactate metabolism in human health and disease |
| title_sort | lactate metabolism in human health and disease |
| url | https://doi.org/10.1038/s41392-022-01151-3 |
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