The Role of Oxidative Stress in Kidney Injury
Acute kidney injury and chronic kidney disease are among the most common non-communicable diseases in the developed world, with increasing prevalence. Patients with acute kidney injury are at an increased risk of developing chronic kidney disease. One of kidney injury’s most common clinical sequelae...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/12/9/1772 |
| _version_ | 1797581478709690368 |
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| author | Nejc Piko Sebastjan Bevc Radovan Hojs Robert Ekart |
| author_facet | Nejc Piko Sebastjan Bevc Radovan Hojs Robert Ekart |
| author_sort | Nejc Piko |
| collection | DOAJ |
| description | Acute kidney injury and chronic kidney disease are among the most common non-communicable diseases in the developed world, with increasing prevalence. Patients with acute kidney injury are at an increased risk of developing chronic kidney disease. One of kidney injury’s most common clinical sequelae is increased cardiovascular morbidity and mortality. In recent years, new insights into the pathophysiology of renal damage have been made. Oxidative stress is the imbalance favoring the increased generation of ROS and/or reduced body’s innate antioxidant defense mechanisms and is of pivotal importance, not only in the development and progression of kidney disease but also in understanding the enhanced cardiovascular risk in these patients. This article summarizes and emphasizes the role of oxidative stress in acute kidney injury, various forms of chronic kidney disease, and also in patients on renal replacement therapy (hemodialysis, peritoneal dialysis, and after kidney transplant). Additionally, the role of oxidative stress in the development of drug-related nephrotoxicity and also in the development after exposure to various environmental and occupational pollutants is presented. |
| first_indexed | 2024-03-10T23:05:05Z |
| format | Article |
| id | doaj.art-071d8de50c804ebd8bb8be79c0f667e2 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T23:05:05Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-071d8de50c804ebd8bb8be79c0f667e22023-11-19T09:20:14ZengMDPI AGAntioxidants2076-39212023-09-01129177210.3390/antiox12091772The Role of Oxidative Stress in Kidney InjuryNejc Piko0Sebastjan Bevc1Radovan Hojs2Robert Ekart3Department of Dialysis, Clinic for Internal Medicine, University Medical Centre, 2000 Maribor, SloveniaDepartment of Nephrology, Clinic for Internal Medicine, University Medical Centre, 2000 Maribor, SloveniaDepartment of Nephrology, Clinic for Internal Medicine, University Medical Centre, 2000 Maribor, SloveniaDepartment of Dialysis, Clinic for Internal Medicine, University Medical Centre, 2000 Maribor, SloveniaAcute kidney injury and chronic kidney disease are among the most common non-communicable diseases in the developed world, with increasing prevalence. Patients with acute kidney injury are at an increased risk of developing chronic kidney disease. One of kidney injury’s most common clinical sequelae is increased cardiovascular morbidity and mortality. In recent years, new insights into the pathophysiology of renal damage have been made. Oxidative stress is the imbalance favoring the increased generation of ROS and/or reduced body’s innate antioxidant defense mechanisms and is of pivotal importance, not only in the development and progression of kidney disease but also in understanding the enhanced cardiovascular risk in these patients. This article summarizes and emphasizes the role of oxidative stress in acute kidney injury, various forms of chronic kidney disease, and also in patients on renal replacement therapy (hemodialysis, peritoneal dialysis, and after kidney transplant). Additionally, the role of oxidative stress in the development of drug-related nephrotoxicity and also in the development after exposure to various environmental and occupational pollutants is presented.https://www.mdpi.com/2076-3921/12/9/1772acute kidney injuryacute tubular necrosischronic kidney diseaseoxidative stressreactive oxygen species |
| spellingShingle | Nejc Piko Sebastjan Bevc Radovan Hojs Robert Ekart The Role of Oxidative Stress in Kidney Injury Antioxidants acute kidney injury acute tubular necrosis chronic kidney disease oxidative stress reactive oxygen species |
| title | The Role of Oxidative Stress in Kidney Injury |
| title_full | The Role of Oxidative Stress in Kidney Injury |
| title_fullStr | The Role of Oxidative Stress in Kidney Injury |
| title_full_unstemmed | The Role of Oxidative Stress in Kidney Injury |
| title_short | The Role of Oxidative Stress in Kidney Injury |
| title_sort | role of oxidative stress in kidney injury |
| topic | acute kidney injury acute tubular necrosis chronic kidney disease oxidative stress reactive oxygen species |
| url | https://www.mdpi.com/2076-3921/12/9/1772 |
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