Repeated verum but not placebo acupuncture normalizes connectivity in brain regions dysregulated in chronic pain
Acupuncture, an ancient East Asian therapy, is aimed at rectifying the imbalance within the body caused by disease. Studies evaluating the efficacy of acupuncture with neuroimaging tend to concentrate on brain regions within the pain matrix, associated with acute pain. We, however, focused on the ef...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2015-01-01
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| Series: | NeuroImage: Clinical |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158215001722 |
| _version_ | 1818613562606616576 |
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| author | Natalia Egorova Randy L. Gollub Jian Kong |
| author_facet | Natalia Egorova Randy L. Gollub Jian Kong |
| author_sort | Natalia Egorova |
| collection | DOAJ |
| description | Acupuncture, an ancient East Asian therapy, is aimed at rectifying the imbalance within the body caused by disease. Studies evaluating the efficacy of acupuncture with neuroimaging tend to concentrate on brain regions within the pain matrix, associated with acute pain. We, however, focused on the effect of repeated acupuncture treatment specifically on brain regions known to support functions dysregulated in chronic pain disorders. Transition to chronic pain is associated with increased attention to pain, emotional rumination, nociceptive memory and avoidance learning, resulting in brain connectivity changes, specifically affecting the periaqueductal gray (PAG), medial frontal cortex (MFC) and bilateral hippocampus (Hpc). We demonstrate that the PAG–MFC and PAG–Hpc connectivity in patients with chronic pain due to knee osteoarthritis indeed correlates with clinical severity scores and further show that verum acupuncture-induced improvement in pain scores (compared to sham) is related to the modulation of PAG–MFC and PAG–Hpc connectivity in the predicted direction. This study shows that repeated verum acupuncture might act by restoring the balance in the connectivity of the key pain brain regions, altering pain-related attention and memory. |
| first_indexed | 2024-12-16T16:04:06Z |
| format | Article |
| id | doaj.art-071e65c903bb4023a056ee9a91fcd8b4 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-16T16:04:06Z |
| publishDate | 2015-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-071e65c903bb4023a056ee9a91fcd8b42022-12-21T22:25:23ZengElsevierNeuroImage: Clinical2213-15822015-01-019C43043510.1016/j.nicl.2015.09.012Repeated verum but not placebo acupuncture normalizes connectivity in brain regions dysregulated in chronic painNatalia EgorovaRandy L. GollubJian KongAcupuncture, an ancient East Asian therapy, is aimed at rectifying the imbalance within the body caused by disease. Studies evaluating the efficacy of acupuncture with neuroimaging tend to concentrate on brain regions within the pain matrix, associated with acute pain. We, however, focused on the effect of repeated acupuncture treatment specifically on brain regions known to support functions dysregulated in chronic pain disorders. Transition to chronic pain is associated with increased attention to pain, emotional rumination, nociceptive memory and avoidance learning, resulting in brain connectivity changes, specifically affecting the periaqueductal gray (PAG), medial frontal cortex (MFC) and bilateral hippocampus (Hpc). We demonstrate that the PAG–MFC and PAG–Hpc connectivity in patients with chronic pain due to knee osteoarthritis indeed correlates with clinical severity scores and further show that verum acupuncture-induced improvement in pain scores (compared to sham) is related to the modulation of PAG–MFC and PAG–Hpc connectivity in the predicted direction. This study shows that repeated verum acupuncture might act by restoring the balance in the connectivity of the key pain brain regions, altering pain-related attention and memory.http://www.sciencedirect.com/science/article/pii/S2213158215001722AcupunctureResting state fMRIChronic painOsteoarthritis |
| spellingShingle | Natalia Egorova Randy L. Gollub Jian Kong Repeated verum but not placebo acupuncture normalizes connectivity in brain regions dysregulated in chronic pain NeuroImage: Clinical Acupuncture Resting state fMRI Chronic pain Osteoarthritis |
| title | Repeated verum but not placebo acupuncture normalizes connectivity in brain regions dysregulated in chronic pain |
| title_full | Repeated verum but not placebo acupuncture normalizes connectivity in brain regions dysregulated in chronic pain |
| title_fullStr | Repeated verum but not placebo acupuncture normalizes connectivity in brain regions dysregulated in chronic pain |
| title_full_unstemmed | Repeated verum but not placebo acupuncture normalizes connectivity in brain regions dysregulated in chronic pain |
| title_short | Repeated verum but not placebo acupuncture normalizes connectivity in brain regions dysregulated in chronic pain |
| title_sort | repeated verum but not placebo acupuncture normalizes connectivity in brain regions dysregulated in chronic pain |
| topic | Acupuncture Resting state fMRI Chronic pain Osteoarthritis |
| url | http://www.sciencedirect.com/science/article/pii/S2213158215001722 |
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