The network characteristics in schizophrenia with prominent negative symptoms: a multimodal fusion study
Abstract Previous studies on putative neural mechanisms of negative symptoms in schizophrenia mainly used single modal imaging data, and seldom utilized schizophrenia patients with prominent negative symptoms (PNS).This study adopted the multimodal fusion method and recruited a homogeneous sample wi...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-01-01
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| Series: | Schizophrenia |
| Online Access: | https://doi.org/10.1038/s41537-023-00408-2 |
| _version_ | 1797209253285462016 |
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| author | Li Kong Yao Zhang Xu-ming Wu Xiao-xiao Wang Hai-su Wu Shuai-biao Li Min-yi Chu Yi Wang Simon S. Y. Lui Qin-yu Lv Zheng-hui Yi Raymond C. K. Chan |
| author_facet | Li Kong Yao Zhang Xu-ming Wu Xiao-xiao Wang Hai-su Wu Shuai-biao Li Min-yi Chu Yi Wang Simon S. Y. Lui Qin-yu Lv Zheng-hui Yi Raymond C. K. Chan |
| author_sort | Li Kong |
| collection | DOAJ |
| description | Abstract Previous studies on putative neural mechanisms of negative symptoms in schizophrenia mainly used single modal imaging data, and seldom utilized schizophrenia patients with prominent negative symptoms (PNS).This study adopted the multimodal fusion method and recruited a homogeneous sample with PNS. We aimed to identify negative symptoms-related structural and functional neural correlates of schizophrenia. Structural magnetic resonance imaging (sMRI) and resting-state functional MRI (rs-fMRI) were performed in 31 schizophrenia patients with PNS and 33 demographically matched healthy controls.Compared to healthy controls, schizophrenia patients with PNS exhibited significantly altered functional activations in the default mode network (DMN) and had structural gray matter volume (GMV) alterations in the cerebello-thalamo-cortical network. Correlational analyses showed that negative symptoms severity was significantly correlated with the cerebello-thalamo-cortical structural network, but not with the DMN network in schizophrenia patients with PNS.Our findings highlight the important role of the cerebello-thalamo-cortical structural network underpinning the neuropathology of negative symptoms in schizophrenia. Future research should recruit a large sample and schizophrenia patients without PNS, and apply adjustments for multiple comparison, to verify our preliminary findings. |
| first_indexed | 2024-03-08T12:36:04Z |
| format | Article |
| id | doaj.art-071e69f4798b4095a4fa4484278c6969 |
| institution | Directory Open Access Journal |
| issn | 2754-6993 |
| language | English |
| last_indexed | 2024-04-24T09:51:46Z |
| publishDate | 2024-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Schizophrenia |
| spelling | doaj.art-071e69f4798b4095a4fa4484278c69692024-04-14T11:19:18ZengNature PortfolioSchizophrenia2754-69932024-01-011011610.1038/s41537-023-00408-2The network characteristics in schizophrenia with prominent negative symptoms: a multimodal fusion studyLi Kong0Yao Zhang1Xu-ming Wu2Xiao-xiao Wang3Hai-su Wu4Shuai-biao Li5Min-yi Chu6Yi Wang7Simon S. Y. Lui8Qin-yu Lv9Zheng-hui Yi10Raymond C. K. Chan11Department of Psychology, Shanghai Normal UniversityShanghai Mental Health Centre, Shanghai Jiao Tong University School of MedicineNantong Fourth People’s HospitalShanghai Mental Health Centre, Shanghai Jiao Tong University School of MedicineShanghai Mental Health Centre, Shanghai Jiao Tong University School of MedicineShanghai Mental Health Centre, Shanghai Jiao Tong University School of MedicineShanghai Mental Health Centre, Shanghai Jiao Tong University School of MedicineNeuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of SciencesDepartment of Psychiatry, School of Clinical Medicine, The University of Hong KongShanghai Mental Health Centre, Shanghai Jiao Tong University School of MedicineShanghai Mental Health Centre, Shanghai Jiao Tong University School of MedicineShanghai Mental Health Centre, Shanghai Jiao Tong University School of MedicineAbstract Previous studies on putative neural mechanisms of negative symptoms in schizophrenia mainly used single modal imaging data, and seldom utilized schizophrenia patients with prominent negative symptoms (PNS).This study adopted the multimodal fusion method and recruited a homogeneous sample with PNS. We aimed to identify negative symptoms-related structural and functional neural correlates of schizophrenia. Structural magnetic resonance imaging (sMRI) and resting-state functional MRI (rs-fMRI) were performed in 31 schizophrenia patients with PNS and 33 demographically matched healthy controls.Compared to healthy controls, schizophrenia patients with PNS exhibited significantly altered functional activations in the default mode network (DMN) and had structural gray matter volume (GMV) alterations in the cerebello-thalamo-cortical network. Correlational analyses showed that negative symptoms severity was significantly correlated with the cerebello-thalamo-cortical structural network, but not with the DMN network in schizophrenia patients with PNS.Our findings highlight the important role of the cerebello-thalamo-cortical structural network underpinning the neuropathology of negative symptoms in schizophrenia. Future research should recruit a large sample and schizophrenia patients without PNS, and apply adjustments for multiple comparison, to verify our preliminary findings.https://doi.org/10.1038/s41537-023-00408-2 |
| spellingShingle | Li Kong Yao Zhang Xu-ming Wu Xiao-xiao Wang Hai-su Wu Shuai-biao Li Min-yi Chu Yi Wang Simon S. Y. Lui Qin-yu Lv Zheng-hui Yi Raymond C. K. Chan The network characteristics in schizophrenia with prominent negative symptoms: a multimodal fusion study Schizophrenia |
| title | The network characteristics in schizophrenia with prominent negative symptoms: a multimodal fusion study |
| title_full | The network characteristics in schizophrenia with prominent negative symptoms: a multimodal fusion study |
| title_fullStr | The network characteristics in schizophrenia with prominent negative symptoms: a multimodal fusion study |
| title_full_unstemmed | The network characteristics in schizophrenia with prominent negative symptoms: a multimodal fusion study |
| title_short | The network characteristics in schizophrenia with prominent negative symptoms: a multimodal fusion study |
| title_sort | network characteristics in schizophrenia with prominent negative symptoms a multimodal fusion study |
| url | https://doi.org/10.1038/s41537-023-00408-2 |
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