The Effects of Boswellia Resin Extract on Dopaminergic Cell line, SK-N-SH, against MPP+-Induced Neurotoxicity
Introduction: Oxidative stress and neuroinflammation are involved in neurodegeneration procedure in Parkinson’s disease. Recently, neuroprotective potential of Boswellia resin has been demonstrated. Therefore, this study examined whether administration of Boswellia resin would attenuate MPP+- induce...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Iran University of Medical Sciences
2011-10-01
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| Series: | Basic and Clinical Neuroscience |
| Subjects: | |
| Online Access: | http://bcn.tums.ac.ir/browse.php?a_code=A-10-1-84&slc_lang=en&sid=1 |
| _version_ | 1797283768301518848 |
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| author | Sareh Kazmi Laya Kafami Ahmad Ebrahimi Behnam Jameie Mohammad Taghi Joghataiee |
| author_facet | Sareh Kazmi Laya Kafami Ahmad Ebrahimi Behnam Jameie Mohammad Taghi Joghataiee |
| author_sort | Sareh Kazmi |
| collection | DOAJ |
| description | Introduction: Oxidative stress and neuroinflammation are involved in neurodegeneration procedure in Parkinson’s disease. Recently, neuroprotective potential of Boswellia resin has been demonstrated. Therefore, this study examined whether administration of Boswellia resin would attenuate MPP+- induced neuronal death in SK-N-SH- cell line, a human dopaminergic neurons- in vitro. Methods: Boswellia resin extract was added to culture medium (10μg/ml) before and after exposure of SK-N-SH cell line to MPP+ (1000μM). Cell viability and apoptosis features were assessed using MTT and Hoechst staining, respectively. Results: Treatment with Boswellia resin 2 and 3h prior to MPP ° exposure and up to 60 minutes after MPP ° exposure significantly increased cell viability compare to untreated cells. Apoptotic features were also reduced significantly by Boswellia resin (10 μg/ml) compare to that of control untreated cells. Discussion: Boswellia resin has neuroprotective effects on dopaminergic neurons which can be applicable in Parkinson’s disease. |
| first_indexed | 2024-03-07T17:36:37Z |
| format | Article |
| id | doaj.art-071f7e7cc71a4481ad19d028aa3b3272 |
| institution | Directory Open Access Journal |
| issn | 2008-126X 2228-7442 |
| language | English |
| last_indexed | 2024-03-07T17:36:37Z |
| publishDate | 2011-10-01 |
| publisher | Iran University of Medical Sciences |
| record_format | Article |
| series | Basic and Clinical Neuroscience |
| spelling | doaj.art-071f7e7cc71a4481ad19d028aa3b32722024-03-02T16:44:45ZengIran University of Medical SciencesBasic and Clinical Neuroscience2008-126X2228-74422011-10-01311722The Effects of Boswellia Resin Extract on Dopaminergic Cell line, SK-N-SH, against MPP+-Induced NeurotoxicitySareh KazmiLaya KafamiAhmad EbrahimiBehnam JameieMohammad Taghi JoghataieeIntroduction: Oxidative stress and neuroinflammation are involved in neurodegeneration procedure in Parkinson’s disease. Recently, neuroprotective potential of Boswellia resin has been demonstrated. Therefore, this study examined whether administration of Boswellia resin would attenuate MPP+- induced neuronal death in SK-N-SH- cell line, a human dopaminergic neurons- in vitro. Methods: Boswellia resin extract was added to culture medium (10μg/ml) before and after exposure of SK-N-SH cell line to MPP+ (1000μM). Cell viability and apoptosis features were assessed using MTT and Hoechst staining, respectively. Results: Treatment with Boswellia resin 2 and 3h prior to MPP ° exposure and up to 60 minutes after MPP ° exposure significantly increased cell viability compare to untreated cells. Apoptotic features were also reduced significantly by Boswellia resin (10 μg/ml) compare to that of control untreated cells. Discussion: Boswellia resin has neuroprotective effects on dopaminergic neurons which can be applicable in Parkinson’s disease.http://bcn.tums.ac.ir/browse.php?a_code=A-10-1-84&slc_lang=en&sid=1Parkinson’s DiseaseBoswellia ResinSK-N-SH Cell LineMPP° |
| spellingShingle | Sareh Kazmi Laya Kafami Ahmad Ebrahimi Behnam Jameie Mohammad Taghi Joghataiee The Effects of Boswellia Resin Extract on Dopaminergic Cell line, SK-N-SH, against MPP+-Induced Neurotoxicity Basic and Clinical Neuroscience Parkinson’s Disease Boswellia Resin SK-N-SH Cell Line MPP° |
| title | The Effects of Boswellia Resin Extract on Dopaminergic Cell line, SK-N-SH, against MPP+-Induced Neurotoxicity |
| title_full | The Effects of Boswellia Resin Extract on Dopaminergic Cell line, SK-N-SH, against MPP+-Induced Neurotoxicity |
| title_fullStr | The Effects of Boswellia Resin Extract on Dopaminergic Cell line, SK-N-SH, against MPP+-Induced Neurotoxicity |
| title_full_unstemmed | The Effects of Boswellia Resin Extract on Dopaminergic Cell line, SK-N-SH, against MPP+-Induced Neurotoxicity |
| title_short | The Effects of Boswellia Resin Extract on Dopaminergic Cell line, SK-N-SH, against MPP+-Induced Neurotoxicity |
| title_sort | effects of boswellia resin extract on dopaminergic cell line sk n sh against mpp induced neurotoxicity |
| topic | Parkinson’s Disease Boswellia Resin SK-N-SH Cell Line MPP° |
| url | http://bcn.tums.ac.ir/browse.php?a_code=A-10-1-84&slc_lang=en&sid=1 |
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