Assessment of Dual Life Stage Antiplasmodial Activity of British Seaweeds
Terrestrial plants have proven to be a prolific producer of clinically effective antimalarial drugs, but the antimalarial potential of seaweeds has been little explored. The main aim of this study was to assess the in vitro chemotherapeutical and prophylactic potential of the extracts of twenty-thre...
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| Format: | Article |
| Language: | English |
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MDPI AG
2013-10-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/11/10/4019 |
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| author | Deniz Tasdemir Maria M. Mota Gerald Blunden Maurice Ayamba Itoe Jasmine Spavieri Andrea Allmendinger Marcel Kaiser |
| author_facet | Deniz Tasdemir Maria M. Mota Gerald Blunden Maurice Ayamba Itoe Jasmine Spavieri Andrea Allmendinger Marcel Kaiser |
| author_sort | Deniz Tasdemir |
| collection | DOAJ |
| description | Terrestrial plants have proven to be a prolific producer of clinically effective antimalarial drugs, but the antimalarial potential of seaweeds has been little explored. The main aim of this study was to assess the in vitro chemotherapeutical and prophylactic potential of the extracts of twenty-three seaweeds collected from the south coast of England against blood stage (BS) and liver stage (LS) Plasmodium parasites. The majority (14) of the extracts were active against BS of P. falciparum, with brown seaweeds Cystoseira tamariscifolia, C. baccata and the green seaweed Ulva lactuca being the most active (IC50s around 3 μg/mL). The extracts generally had high selectivity indices (>10). Eight seaweed extracts inhibited the growth of LS parasites of P. berghei without any obvious effect on the viability of the human hepatoma (Huh7) cells, and the highest potential was exerted by U. lactuca and red seaweeds Ceramium virgatum and Halopitys incurvus (IC50 values 14.9 to 28.8 μg/mL). The LS-active extracts inhibited one or more key enzymes of the malarial type-II fatty acid biosynthesis (FAS-II) pathway, a drug target specific for LS. Except for the red seaweed Halopitys incurvus, all LS-active extracts showed dual activity versus both malarial intracellular stage parasites. This is the first report of LS antiplasmodial activity and dual stage inhibitory potential of seaweeds. |
| first_indexed | 2024-04-11T12:15:40Z |
| format | Article |
| id | doaj.art-071f9d14472e4514904f201431f6f9a9 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T12:15:40Z |
| publishDate | 2013-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-071f9d14472e4514904f201431f6f9a92022-12-22T04:24:19ZengMDPI AGMarine Drugs1660-33972013-10-0111104019403410.3390/md11104019Assessment of Dual Life Stage Antiplasmodial Activity of British SeaweedsDeniz TasdemirMaria M. MotaGerald BlundenMaurice Ayamba ItoeJasmine SpavieriAndrea AllmendingerMarcel KaiserTerrestrial plants have proven to be a prolific producer of clinically effective antimalarial drugs, but the antimalarial potential of seaweeds has been little explored. The main aim of this study was to assess the in vitro chemotherapeutical and prophylactic potential of the extracts of twenty-three seaweeds collected from the south coast of England against blood stage (BS) and liver stage (LS) Plasmodium parasites. The majority (14) of the extracts were active against BS of P. falciparum, with brown seaweeds Cystoseira tamariscifolia, C. baccata and the green seaweed Ulva lactuca being the most active (IC50s around 3 μg/mL). The extracts generally had high selectivity indices (>10). Eight seaweed extracts inhibited the growth of LS parasites of P. berghei without any obvious effect on the viability of the human hepatoma (Huh7) cells, and the highest potential was exerted by U. lactuca and red seaweeds Ceramium virgatum and Halopitys incurvus (IC50 values 14.9 to 28.8 μg/mL). The LS-active extracts inhibited one or more key enzymes of the malarial type-II fatty acid biosynthesis (FAS-II) pathway, a drug target specific for LS. Except for the red seaweed Halopitys incurvus, all LS-active extracts showed dual activity versus both malarial intracellular stage parasites. This is the first report of LS antiplasmodial activity and dual stage inhibitory potential of seaweeds.http://www.mdpi.com/1660-3397/11/10/4019seaweedmarine algamalariaPlasmodiummalaria prophylaxisfatty acid biosynthesisliver stageblood stage |
| spellingShingle | Deniz Tasdemir Maria M. Mota Gerald Blunden Maurice Ayamba Itoe Jasmine Spavieri Andrea Allmendinger Marcel Kaiser Assessment of Dual Life Stage Antiplasmodial Activity of British Seaweeds Marine Drugs seaweed marine alga malaria Plasmodium malaria prophylaxis fatty acid biosynthesis liver stage blood stage |
| title | Assessment of Dual Life Stage Antiplasmodial Activity of British Seaweeds |
| title_full | Assessment of Dual Life Stage Antiplasmodial Activity of British Seaweeds |
| title_fullStr | Assessment of Dual Life Stage Antiplasmodial Activity of British Seaweeds |
| title_full_unstemmed | Assessment of Dual Life Stage Antiplasmodial Activity of British Seaweeds |
| title_short | Assessment of Dual Life Stage Antiplasmodial Activity of British Seaweeds |
| title_sort | assessment of dual life stage antiplasmodial activity of british seaweeds |
| topic | seaweed marine alga malaria Plasmodium malaria prophylaxis fatty acid biosynthesis liver stage blood stage |
| url | http://www.mdpi.com/1660-3397/11/10/4019 |
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