Antagonistic Center-Surround Mechanisms for Direction Selectivity in the Retina
Summary: An antagonistic center-surround receptive field is a key feature in sensory processing, but how it contributes to specific computations such as direction selectivity is often unknown. Retinal On-starburst amacrine cells (SACs), which mediate direction selectivity in direction-selective gang...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-05-01
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| Series: | Cell Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S221112472030557X |
| _version_ | 1818279903817105408 |
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| author | Lea Ankri Elishai Ezra-Tsur Shir R. Maimon Nathali Kaushansky Michal Rivlin-Etzion |
| author_facet | Lea Ankri Elishai Ezra-Tsur Shir R. Maimon Nathali Kaushansky Michal Rivlin-Etzion |
| author_sort | Lea Ankri |
| collection | DOAJ |
| description | Summary: An antagonistic center-surround receptive field is a key feature in sensory processing, but how it contributes to specific computations such as direction selectivity is often unknown. Retinal On-starburst amacrine cells (SACs), which mediate direction selectivity in direction-selective ganglion cells (DSGCs), exhibit antagonistic receptive field organization: depolarizing to light increments and decrements in their center and surround, respectively. We find that a repetitive stimulation exhausts SAC center and enhances its surround and use it to study how center-surround responses contribute to direction selectivity. Center, but not surround, activation induces direction-selective responses in SACs. Nevertheless, both SAC center and surround elicited direction-selective responses in DSGCs, but to opposite directions. Physiological and modeling data suggest that the opposing direction selectivity can result from inverted temporal balance between excitation and inhibition in DSGCs, implying that SAC’s response timing dictates direction selectivity. Our findings reveal antagonistic center-surround mechanisms for direction selectivity and demonstrate how context-dependent receptive field reorganization enables flexible computations. |
| first_indexed | 2024-12-12T23:40:44Z |
| format | Article |
| id | doaj.art-07201b11295242b7aa0539998f6b6ac0 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-12T23:40:44Z |
| publishDate | 2020-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-07201b11295242b7aa0539998f6b6ac02022-12-22T00:07:09ZengElsevierCell Reports2211-12472020-05-01315Antagonistic Center-Surround Mechanisms for Direction Selectivity in the RetinaLea Ankri0Elishai Ezra-Tsur1Shir R. Maimon2Nathali Kaushansky3Michal Rivlin-Etzion4Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, IsraelDepartment of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel; Department of Mathematics and Computer Science, The Open University of Israel, Ra’anana, IsraelDepartment of Neurobiology, Weizmann Institute of Science, Rehovot 76100, IsraelDepartment of Neurobiology, Weizmann Institute of Science, Rehovot 76100, IsraelDepartment of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel; Corresponding authorSummary: An antagonistic center-surround receptive field is a key feature in sensory processing, but how it contributes to specific computations such as direction selectivity is often unknown. Retinal On-starburst amacrine cells (SACs), which mediate direction selectivity in direction-selective ganglion cells (DSGCs), exhibit antagonistic receptive field organization: depolarizing to light increments and decrements in their center and surround, respectively. We find that a repetitive stimulation exhausts SAC center and enhances its surround and use it to study how center-surround responses contribute to direction selectivity. Center, but not surround, activation induces direction-selective responses in SACs. Nevertheless, both SAC center and surround elicited direction-selective responses in DSGCs, but to opposite directions. Physiological and modeling data suggest that the opposing direction selectivity can result from inverted temporal balance between excitation and inhibition in DSGCs, implying that SAC’s response timing dictates direction selectivity. Our findings reveal antagonistic center-surround mechanisms for direction selectivity and demonstrate how context-dependent receptive field reorganization enables flexible computations.http://www.sciencedirect.com/science/article/pii/S221112472030557Xneural circuitsneural computationvisual processingretinaantagonistic center-surroundreceptive field |
| spellingShingle | Lea Ankri Elishai Ezra-Tsur Shir R. Maimon Nathali Kaushansky Michal Rivlin-Etzion Antagonistic Center-Surround Mechanisms for Direction Selectivity in the Retina Cell Reports neural circuits neural computation visual processing retina antagonistic center-surround receptive field |
| title | Antagonistic Center-Surround Mechanisms for Direction Selectivity in the Retina |
| title_full | Antagonistic Center-Surround Mechanisms for Direction Selectivity in the Retina |
| title_fullStr | Antagonistic Center-Surround Mechanisms for Direction Selectivity in the Retina |
| title_full_unstemmed | Antagonistic Center-Surround Mechanisms for Direction Selectivity in the Retina |
| title_short | Antagonistic Center-Surround Mechanisms for Direction Selectivity in the Retina |
| title_sort | antagonistic center surround mechanisms for direction selectivity in the retina |
| topic | neural circuits neural computation visual processing retina antagonistic center-surround receptive field |
| url | http://www.sciencedirect.com/science/article/pii/S221112472030557X |
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