Measurement of Exhaled Nitric Oxide in 456 Lung Cancer Patients Using a Ringdown FENO Analyzer
The objective of this study was to investigate the clinical value of exhaled nitric oxide (NO) for diagnosing lung cancer patients by using a relatively large sample. An online and near-real-time ringdown exhaled NO analyzer calibrated by an electrochemical sensor at clinical was used for breath ana...
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MDPI AG
2021-05-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/11/6/352 |
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| author | Jing Li Qingyuan Li Xin Wei Qing Chen Meixiu Sun Yingxin Li |
| author_facet | Jing Li Qingyuan Li Xin Wei Qing Chen Meixiu Sun Yingxin Li |
| author_sort | Jing Li |
| collection | DOAJ |
| description | The objective of this study was to investigate the clinical value of exhaled nitric oxide (NO) for diagnosing lung cancer patients by using a relatively large sample. An online and near-real-time ringdown exhaled NO analyzer calibrated by an electrochemical sensor at clinical was used for breath analysis. A total of 740 breath samples from 284 healthy control subjects (H) and 456 lung cancer patients (LC) were collected. The recorded data included exhaled NO, medications taken within the last half month, demographics, fasting status and smoking status. The LC had a significantly higher level of exhaled NO than the H (H: 21.0 ± 12.1 ppb vs. LC: 34.1 ± 17.2 ppb). The area under the receiver operating characteristic curve for exhaled NO predicting LC and H was 0.728 (sensitivity was 0.798; specificity was 0.55). There was no significant difference in exhaled NO level between groups divided by different types of LC, tumor node metastasis (TNM) stage, sex, smoking status, age, body mass index (BMI) or fasting status. Exhaled NO level alone is not a useful clinical tool for identifying lung cancer, but it should be considered when developing a diagnosis model of lung cancer by using breath analysis. |
| first_indexed | 2024-03-10T10:50:23Z |
| format | Article |
| id | doaj.art-07209316adee46d39af4c14ab06475e7 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-10T10:50:23Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-07209316adee46d39af4c14ab06475e72023-11-21T22:16:56ZengMDPI AGMetabolites2218-19892021-05-0111635210.3390/metabo11060352Measurement of Exhaled Nitric Oxide in 456 Lung Cancer Patients Using a Ringdown FENO AnalyzerJing Li0Qingyuan Li1Xin Wei2Qing Chen3Meixiu Sun4Yingxin Li5Institute of Biomedical Engineering, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin 100730, ChinaInstitute of Biomedical Engineering, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin 100730, ChinaInstitute of Biomedical Engineering, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin 100730, ChinaNational Clinical Research Center for Cancer, Deparment of Cardio-Pulmonary Function, Cancer Institute and Hospital, Tianjin Medical University, Tianjin 300070, ChinaInstitute of Biomedical Engineering, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin 100730, ChinaInstitute of Biomedical Engineering, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin 100730, ChinaThe objective of this study was to investigate the clinical value of exhaled nitric oxide (NO) for diagnosing lung cancer patients by using a relatively large sample. An online and near-real-time ringdown exhaled NO analyzer calibrated by an electrochemical sensor at clinical was used for breath analysis. A total of 740 breath samples from 284 healthy control subjects (H) and 456 lung cancer patients (LC) were collected. The recorded data included exhaled NO, medications taken within the last half month, demographics, fasting status and smoking status. The LC had a significantly higher level of exhaled NO than the H (H: 21.0 ± 12.1 ppb vs. LC: 34.1 ± 17.2 ppb). The area under the receiver operating characteristic curve for exhaled NO predicting LC and H was 0.728 (sensitivity was 0.798; specificity was 0.55). There was no significant difference in exhaled NO level between groups divided by different types of LC, tumor node metastasis (TNM) stage, sex, smoking status, age, body mass index (BMI) or fasting status. Exhaled NO level alone is not a useful clinical tool for identifying lung cancer, but it should be considered when developing a diagnosis model of lung cancer by using breath analysis.https://www.mdpi.com/2218-1989/11/6/352exhaled NOlung cancerbreath biomarkerscavity ringdown spectroscopy (CRDS) |
| spellingShingle | Jing Li Qingyuan Li Xin Wei Qing Chen Meixiu Sun Yingxin Li Measurement of Exhaled Nitric Oxide in 456 Lung Cancer Patients Using a Ringdown FENO Analyzer Metabolites exhaled NO lung cancer breath biomarkers cavity ringdown spectroscopy (CRDS) |
| title | Measurement of Exhaled Nitric Oxide in 456 Lung Cancer Patients Using a Ringdown FENO Analyzer |
| title_full | Measurement of Exhaled Nitric Oxide in 456 Lung Cancer Patients Using a Ringdown FENO Analyzer |
| title_fullStr | Measurement of Exhaled Nitric Oxide in 456 Lung Cancer Patients Using a Ringdown FENO Analyzer |
| title_full_unstemmed | Measurement of Exhaled Nitric Oxide in 456 Lung Cancer Patients Using a Ringdown FENO Analyzer |
| title_short | Measurement of Exhaled Nitric Oxide in 456 Lung Cancer Patients Using a Ringdown FENO Analyzer |
| title_sort | measurement of exhaled nitric oxide in 456 lung cancer patients using a ringdown feno analyzer |
| topic | exhaled NO lung cancer breath biomarkers cavity ringdown spectroscopy (CRDS) |
| url | https://www.mdpi.com/2218-1989/11/6/352 |
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