SULF 1 gene polymorphism, rs6990375 is in significant association with fetus failure in IVF technique
Background: Sulfatase 1 (SULF1) function is to remove the 6-O-sulphate group from heparan sulfate. This action changes the binding sites of extracellular growth factors. SULF1 expression has been reported to be changed in angiogenesis. We hypothesized that single nucleotide polymorphisms (SNPs) of S...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Shahid Sadoughi University of Medical Science, Yazd, Iran
2015-03-01
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| Series: | Iranian Journal of Reproductive Medicine |
| Online Access: | http://www.ssu.ac.ir/ijrm/index.php/ijrm/article/view/1472/836 |
| _version_ | 1818682788597989376 |
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| author | Eskandar Taghizadeh Seyed Mehdi Kalantar Reza Mahdian Mohammad Hasan Sheikhha Ehsan Farashahi-Yazd Saeed Ghasemi Zahra Shahbazi |
| author_facet | Eskandar Taghizadeh Seyed Mehdi Kalantar Reza Mahdian Mohammad Hasan Sheikhha Ehsan Farashahi-Yazd Saeed Ghasemi Zahra Shahbazi |
| author_sort | Eskandar Taghizadeh |
| collection | DOAJ |
| description | Background: Sulfatase 1 (SULF1) function is to remove the 6-O-sulphate group from heparan sulfate. This action changes the binding sites of extracellular growth factors. SULF1 expression has been reported to be changed in angiogenesis. We hypothesized that single nucleotide polymorphisms (SNPs) of SULF1 would impact clinicopathologic characteristics.
Objective: Study of SULF1 gene polymorphism with fetus failure in in vitro fertilization (IVF) technique.
Materials and Methods: We studied one common (minor allele frequency >0.05) regulatory SNP, rs6990375, with polymerase chain reaction and restriction fragment length polymorphism method, in 53 infertile women with fetus failure in IVF technique and 53 women with at least one healthy child as controls.
Results: We found that rs6990375 is significantly associated with an early failure in IVF and frequency of G allele is high in women with fetus failure in IVF technique (p<0.001).
Conclusion: These findings suggest that SULF1genetic variations may play a role in IVF technique fetus failure. Further studies with large sample sizes on SULF1 SNPs may be useful in support of this claim. |
| first_indexed | 2024-12-17T10:24:25Z |
| format | Article |
| id | doaj.art-07224e298370445db0de94b0150d8d14 |
| institution | Directory Open Access Journal |
| issn | 1680-6433 2008-2177 |
| language | English |
| last_indexed | 2024-12-17T10:24:25Z |
| publishDate | 2015-03-01 |
| publisher | Shahid Sadoughi University of Medical Science, Yazd, Iran |
| record_format | Article |
| series | Iranian Journal of Reproductive Medicine |
| spelling | doaj.art-07224e298370445db0de94b0150d8d142022-12-21T21:52:41ZengShahid Sadoughi University of Medical Science, Yazd, IranIranian Journal of Reproductive Medicine1680-64332008-21772015-03-01134215220SULF 1 gene polymorphism, rs6990375 is in significant association with fetus failure in IVF techniqueEskandar Taghizadeh0Seyed Mehdi Kalantar1Reza Mahdian2Mohammad Hasan Sheikhha3Ehsan Farashahi-Yazd4Saeed Ghasemi5Zahra Shahbazi6Department of Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.Department of Molecular Medicine, Pasteur Institute of Iran, Tehran, Iran.Department of Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.Department of Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.Department of Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.Pasteur Institute of Iran, Tehran, Iran.Background: Sulfatase 1 (SULF1) function is to remove the 6-O-sulphate group from heparan sulfate. This action changes the binding sites of extracellular growth factors. SULF1 expression has been reported to be changed in angiogenesis. We hypothesized that single nucleotide polymorphisms (SNPs) of SULF1 would impact clinicopathologic characteristics. Objective: Study of SULF1 gene polymorphism with fetus failure in in vitro fertilization (IVF) technique. Materials and Methods: We studied one common (minor allele frequency >0.05) regulatory SNP, rs6990375, with polymerase chain reaction and restriction fragment length polymorphism method, in 53 infertile women with fetus failure in IVF technique and 53 women with at least one healthy child as controls. Results: We found that rs6990375 is significantly associated with an early failure in IVF and frequency of G allele is high in women with fetus failure in IVF technique (p<0.001). Conclusion: These findings suggest that SULF1genetic variations may play a role in IVF technique fetus failure. Further studies with large sample sizes on SULF1 SNPs may be useful in support of this claim.http://www.ssu.ac.ir/ijrm/index.php/ijrm/article/view/1472/836 |
| spellingShingle | Eskandar Taghizadeh Seyed Mehdi Kalantar Reza Mahdian Mohammad Hasan Sheikhha Ehsan Farashahi-Yazd Saeed Ghasemi Zahra Shahbazi SULF 1 gene polymorphism, rs6990375 is in significant association with fetus failure in IVF technique Iranian Journal of Reproductive Medicine |
| title | SULF 1 gene polymorphism, rs6990375 is in significant association with fetus failure in IVF technique |
| title_full | SULF 1 gene polymorphism, rs6990375 is in significant association with fetus failure in IVF technique |
| title_fullStr | SULF 1 gene polymorphism, rs6990375 is in significant association with fetus failure in IVF technique |
| title_full_unstemmed | SULF 1 gene polymorphism, rs6990375 is in significant association with fetus failure in IVF technique |
| title_short | SULF 1 gene polymorphism, rs6990375 is in significant association with fetus failure in IVF technique |
| title_sort | sulf 1 gene polymorphism rs6990375 is in significant association with fetus failure in ivf technique |
| url | http://www.ssu.ac.ir/ijrm/index.php/ijrm/article/view/1472/836 |
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