Increased abundance of ADAM9 transcripts in the blood is associated with tissue damage [version 2; referees: 2 approved, 1 approved with reservations]
Background: Members of the ADAM (a disintegrin and metalloprotease domain) family have emerged as critical regulators of cell-cell signaling during development and homeostasis. ADAM9 is consistently overexpressed in various human cancers, and has been shown to play an important role in tumorigenesis...
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2016-10-01
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| Series: | F1000Research |
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| Online Access: | https://f1000research.com/articles/4-89/v2 |
| _version_ | 1811336986666991616 |
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| author | Darawan Rinchai Chidchamai Kewcharoenwong Bianca Kessler Ganjana Lertmemongkolchai Damien Chaussabel |
| author_facet | Darawan Rinchai Chidchamai Kewcharoenwong Bianca Kessler Ganjana Lertmemongkolchai Damien Chaussabel |
| author_sort | Darawan Rinchai |
| collection | DOAJ |
| description | Background: Members of the ADAM (a disintegrin and metalloprotease domain) family have emerged as critical regulators of cell-cell signaling during development and homeostasis. ADAM9 is consistently overexpressed in various human cancers, and has been shown to play an important role in tumorigenesis. However, little is known about the involvement of ADAM9 during immune-mediated processes. Results: Mining of an extensive compendium of transcriptomic datasets identified important gaps in knowledge regarding the possible role of ADAM9 in immunological homeostasis and inflammation: 1) The abundance of ADAM9 transcripts in the blood was increased in patients with acute infection but, 2) changed very little after in vitro exposure to a wide range of pathogen-associated molecular patterns (PAMPs). 3) Furthermore it was found to increase significantly in subjects as a result of tissue injury or tissue remodeling, in absence of infectious processes. Conclusions: Our findings indicate that ADAM9 may constitute a valuable biomarker for the assessment of tissue damage, especially in clinical situations where other inflammatory markers are confounded by infectious processes. |
| first_indexed | 2024-04-13T17:47:31Z |
| format | Article |
| id | doaj.art-0723b2cffe7b4f06842bee2c1680a6fe |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-04-13T17:47:31Z |
| publishDate | 2016-10-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-0723b2cffe7b4f06842bee2c1680a6fe2022-12-22T02:36:51ZengF1000 Research LtdF1000Research2046-14022016-10-01410.12688/f1000research.6241.210567Increased abundance of ADAM9 transcripts in the blood is associated with tissue damage [version 2; referees: 2 approved, 1 approved with reservations]Darawan Rinchai0Chidchamai Kewcharoenwong1Bianca Kessler2Ganjana Lertmemongkolchai3Damien Chaussabel4Systems Biology Department, Sidra Medical and Research Center, Doha, QatarCellular and Molecular Immunology Unit, The Centre for Research and Development of Medical Diagnostic Laboratories (CMDL), Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, 40000, ThailandCellular and Molecular Immunology Unit, The Centre for Research and Development of Medical Diagnostic Laboratories (CMDL), Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, 40000, ThailandCellular and Molecular Immunology Unit, The Centre for Research and Development of Medical Diagnostic Laboratories (CMDL), Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, 40000, ThailandSystems Biology Department, Sidra Medical and Research Center, Doha, QatarBackground: Members of the ADAM (a disintegrin and metalloprotease domain) family have emerged as critical regulators of cell-cell signaling during development and homeostasis. ADAM9 is consistently overexpressed in various human cancers, and has been shown to play an important role in tumorigenesis. However, little is known about the involvement of ADAM9 during immune-mediated processes. Results: Mining of an extensive compendium of transcriptomic datasets identified important gaps in knowledge regarding the possible role of ADAM9 in immunological homeostasis and inflammation: 1) The abundance of ADAM9 transcripts in the blood was increased in patients with acute infection but, 2) changed very little after in vitro exposure to a wide range of pathogen-associated molecular patterns (PAMPs). 3) Furthermore it was found to increase significantly in subjects as a result of tissue injury or tissue remodeling, in absence of infectious processes. Conclusions: Our findings indicate that ADAM9 may constitute a valuable biomarker for the assessment of tissue damage, especially in clinical situations where other inflammatory markers are confounded by infectious processes.https://f1000research.com/articles/4-89/v2GenomicsStructure: Transcription & Translation |
| spellingShingle | Darawan Rinchai Chidchamai Kewcharoenwong Bianca Kessler Ganjana Lertmemongkolchai Damien Chaussabel Increased abundance of ADAM9 transcripts in the blood is associated with tissue damage [version 2; referees: 2 approved, 1 approved with reservations] F1000Research Genomics Structure: Transcription & Translation |
| title | Increased abundance of ADAM9 transcripts in the blood is associated with tissue damage [version 2; referees: 2 approved, 1 approved with reservations] |
| title_full | Increased abundance of ADAM9 transcripts in the blood is associated with tissue damage [version 2; referees: 2 approved, 1 approved with reservations] |
| title_fullStr | Increased abundance of ADAM9 transcripts in the blood is associated with tissue damage [version 2; referees: 2 approved, 1 approved with reservations] |
| title_full_unstemmed | Increased abundance of ADAM9 transcripts in the blood is associated with tissue damage [version 2; referees: 2 approved, 1 approved with reservations] |
| title_short | Increased abundance of ADAM9 transcripts in the blood is associated with tissue damage [version 2; referees: 2 approved, 1 approved with reservations] |
| title_sort | increased abundance of adam9 transcripts in the blood is associated with tissue damage version 2 referees 2 approved 1 approved with reservations |
| topic | Genomics Structure: Transcription & Translation |
| url | https://f1000research.com/articles/4-89/v2 |
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