Association between pulmonary ventilatory function and mild cognitive impairment: A population-based study in rural China
BackgroundMild cognitive impairment (MCI), a reversible intermediate state, plays an important role in the development and prevention of dementia. The relationship between pulmonary function and MCI risk has not yet been well-elucidated.MethodsWe included 2,947 rural Chinese residents aged ≥35 years...
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2022.1038576/full |
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| author | Cuiying Gu Cuiying Gu Mingfeng Ma Jiahui Xu Wei Yuan Ruixue Li Hui Guo Hanshu Gao Wenjing Feng Haiqiang Guo Liqiang Zheng Yao Zhang |
| author_facet | Cuiying Gu Cuiying Gu Mingfeng Ma Jiahui Xu Wei Yuan Ruixue Li Hui Guo Hanshu Gao Wenjing Feng Haiqiang Guo Liqiang Zheng Yao Zhang |
| author_sort | Cuiying Gu |
| collection | DOAJ |
| description | BackgroundMild cognitive impairment (MCI), a reversible intermediate state, plays an important role in the development and prevention of dementia. The relationship between pulmonary function and MCI risk has not yet been well-elucidated.MethodsWe included 2,947 rural Chinese residents aged ≥35 years who were free from a history of stroke, dementia, or other brain diseases and measured pulmonary ventilatory function using calibrated spirometry according to the recommended method. MCI was assessed with the Montreal Cognitive Assessment-Basic for Chinese scale. Logistic regression models and restricted cubic splines with covariate adjustment were performed to explore the association between pulmonary function and MCI risk.ResultsThe prevalence of MCI increased with decreasing pulmonary function, from the lowest quartile to the highest quartile of pulmonary function: 63.9, 50.5, 43.8, and 43.6%, respectively. After adjustment for confounding factors, participants in the first quartile had a significantly increased risk of MCI (ORs, 1.691, 95% CI, 1.267–2.258), with the highest quartile as the reference. In the subgroup analysis, a significant association of pulmonary function and MCI was found in females and those with low physical activity. Meanwhile, we observed an L-shaped relationship between pulmonary function and MCI (Pnon−linear = 0.032).ConclusionsPoor pulmonary function was associated with an increased risk of MCI among rural Chinese adults, and presented a non-linear relationship. These findings remind us of the need for early cognitive assessment in local populations with lower pulmonary function. |
| first_indexed | 2024-04-12T17:25:03Z |
| format | Article |
| id | doaj.art-072621ddfac34cf3a13971e96d4dc7d0 |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-04-12T17:25:03Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-072621ddfac34cf3a13971e96d4dc7d02022-12-22T03:23:19ZengFrontiers Media S.A.Frontiers in Public Health2296-25652022-11-011010.3389/fpubh.2022.10385761038576Association between pulmonary ventilatory function and mild cognitive impairment: A population-based study in rural ChinaCuiying Gu0Cuiying Gu1Mingfeng Ma2Jiahui Xu3Wei Yuan4Ruixue Li5Hui Guo6Hanshu Gao7Wenjing Feng8Haiqiang Guo9Liqiang Zheng10Yao Zhang11Department of Epidemiology, School of Public Health, China Medical University, Shenyang, ChinaMinistry of Education-Shanghai Key Laboratory of Children's Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Cardiology, Fenyang Hospital of Shanxi Province, Fenyang, ChinaDepartment of Epidemiology, School of Public Health, China Medical University, Shenyang, ChinaDepartment of Epidemiology, School of Public Health, China Medical University, Shenyang, ChinaDepartment of Epidemiology, School of Public Health, China Medical University, Shenyang, ChinaDepartment of Epidemiology, School of Public Health, China Medical University, Shenyang, ChinaDepartment of Epidemiology, School of Public Health, China Medical University, Shenyang, ChinaDepartment of Epidemiology, School of Public Health, China Medical University, Shenyang, ChinaDepartment of Health Statistics, China Medical University, Shenyang, ChinaMinistry of Education-Shanghai Key Laboratory of Children's Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, ChinaBackgroundMild cognitive impairment (MCI), a reversible intermediate state, plays an important role in the development and prevention of dementia. The relationship between pulmonary function and MCI risk has not yet been well-elucidated.MethodsWe included 2,947 rural Chinese residents aged ≥35 years who were free from a history of stroke, dementia, or other brain diseases and measured pulmonary ventilatory function using calibrated spirometry according to the recommended method. MCI was assessed with the Montreal Cognitive Assessment-Basic for Chinese scale. Logistic regression models and restricted cubic splines with covariate adjustment were performed to explore the association between pulmonary function and MCI risk.ResultsThe prevalence of MCI increased with decreasing pulmonary function, from the lowest quartile to the highest quartile of pulmonary function: 63.9, 50.5, 43.8, and 43.6%, respectively. After adjustment for confounding factors, participants in the first quartile had a significantly increased risk of MCI (ORs, 1.691, 95% CI, 1.267–2.258), with the highest quartile as the reference. In the subgroup analysis, a significant association of pulmonary function and MCI was found in females and those with low physical activity. Meanwhile, we observed an L-shaped relationship between pulmonary function and MCI (Pnon−linear = 0.032).ConclusionsPoor pulmonary function was associated with an increased risk of MCI among rural Chinese adults, and presented a non-linear relationship. These findings remind us of the need for early cognitive assessment in local populations with lower pulmonary function.https://www.frontiersin.org/articles/10.3389/fpubh.2022.1038576/fullpulmonary functionmild cognitive impairmentcognitioncross-sectional studyrural |
| spellingShingle | Cuiying Gu Cuiying Gu Mingfeng Ma Jiahui Xu Wei Yuan Ruixue Li Hui Guo Hanshu Gao Wenjing Feng Haiqiang Guo Liqiang Zheng Yao Zhang Association between pulmonary ventilatory function and mild cognitive impairment: A population-based study in rural China Frontiers in Public Health pulmonary function mild cognitive impairment cognition cross-sectional study rural |
| title | Association between pulmonary ventilatory function and mild cognitive impairment: A population-based study in rural China |
| title_full | Association between pulmonary ventilatory function and mild cognitive impairment: A population-based study in rural China |
| title_fullStr | Association between pulmonary ventilatory function and mild cognitive impairment: A population-based study in rural China |
| title_full_unstemmed | Association between pulmonary ventilatory function and mild cognitive impairment: A population-based study in rural China |
| title_short | Association between pulmonary ventilatory function and mild cognitive impairment: A population-based study in rural China |
| title_sort | association between pulmonary ventilatory function and mild cognitive impairment a population based study in rural china |
| topic | pulmonary function mild cognitive impairment cognition cross-sectional study rural |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2022.1038576/full |
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