The effect of curcumin-piperine on cardiometabolic, inflammatory and oxidative stress factors and macular vascular density in optical coherence tomography angiography (OCTA) in patients with non-proliferative diabetic retinopathy: Study protocol for a randomized, double-blind controlled trial
Objective: Curcumin is a safe phytochemical with antioxidant, anti-inflammatory, antidiabetic, and lipid-lowering effects. This study aims to investigate the efficacy of curcumin-piperine in non-proliferative diabetic retinopathy.Materials and Methods: In this double-blind randomized trial, 60 diabe...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2023-03-01
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| Series: | Avicenna Journal of Phytomedicine |
| Subjects: | |
| Online Access: | https://ajp.mums.ac.ir/article_21512_deb5958f3d6d71af9ebf2e8e52dae51f.pdf |
| _version_ | 1797894841138413568 |
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| author | Sepide Amini Amirhossein Sahebkar Alireza Dehghani Bijan Iraj Abdolreza Rezaeian-Ramsheh Gholamreza Askari Muhammed Majeed Mohammad Bagherniya |
| author_facet | Sepide Amini Amirhossein Sahebkar Alireza Dehghani Bijan Iraj Abdolreza Rezaeian-Ramsheh Gholamreza Askari Muhammed Majeed Mohammad Bagherniya |
| author_sort | Sepide Amini |
| collection | DOAJ |
| description | Objective: Curcumin is a safe phytochemical with antioxidant, anti-inflammatory, antidiabetic, and lipid-lowering effects. This study aims to investigate the efficacy of curcumin-piperine in non-proliferative diabetic retinopathy.Materials and Methods: In this double-blind randomized trial, 60 diabetic retinopathy patients after meeting the inclusion criteria will be randomly assigned to two groups of curcumin-piperine supplementation (1000 mg per day for 12 weeks) or receiving placebo. The density of small blood vessels in the retina by optical coherence tomography angiography (OCTA), fasting blood glucose, triglyceride, renal indices (blood urea nitrogen and creatinine), high-sensitivity C-reactive protein, total antioxidant capacity, total oxidant status, body mass index, waist circumference, and weight will be measured.Conclusion: If the beneficial effects of curcumin on diabetic retinopathy are observed, this safe, this natural and inexpensive herbal supplement can be considered a therapeutic solution in these patients. |
| first_indexed | 2024-04-10T07:16:54Z |
| format | Article |
| id | doaj.art-0726b9190bb44eb2843642176fdad67f |
| institution | Directory Open Access Journal |
| issn | 2228-7930 2228-7949 |
| language | English |
| last_indexed | 2024-04-10T07:16:54Z |
| publishDate | 2023-03-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Avicenna Journal of Phytomedicine |
| spelling | doaj.art-0726b9190bb44eb2843642176fdad67f2023-02-25T04:30:03ZengMashhad University of Medical SciencesAvicenna Journal of Phytomedicine2228-79302228-79492023-03-0113215316410.22038/ajp.2022.2151221512The effect of curcumin-piperine on cardiometabolic, inflammatory and oxidative stress factors and macular vascular density in optical coherence tomography angiography (OCTA) in patients with non-proliferative diabetic retinopathy: Study protocol for a randomized, double-blind controlled trialSepide Amini0Amirhossein Sahebkar1Alireza Dehghani2Bijan Iraj3Abdolreza Rezaeian-Ramsheh4Gholamreza Askari5Muhammed Majeed6Mohammad Bagherniya7Nutrition and Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranOphthalmology Ward, Feiz Hospital, Isfahan University of Medical Sciences, Isfahan, IranIsfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, IranOphthalmology Ward, Feiz Hospital, Isfahan University of Medical Sciences, Isfahan, IranNutrition and Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, IranSabinsa Corporation, East Windsor, NJ, United StatesNutrition and Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, IranObjective: Curcumin is a safe phytochemical with antioxidant, anti-inflammatory, antidiabetic, and lipid-lowering effects. This study aims to investigate the efficacy of curcumin-piperine in non-proliferative diabetic retinopathy.Materials and Methods: In this double-blind randomized trial, 60 diabetic retinopathy patients after meeting the inclusion criteria will be randomly assigned to two groups of curcumin-piperine supplementation (1000 mg per day for 12 weeks) or receiving placebo. The density of small blood vessels in the retina by optical coherence tomography angiography (OCTA), fasting blood glucose, triglyceride, renal indices (blood urea nitrogen and creatinine), high-sensitivity C-reactive protein, total antioxidant capacity, total oxidant status, body mass index, waist circumference, and weight will be measured.Conclusion: If the beneficial effects of curcumin on diabetic retinopathy are observed, this safe, this natural and inexpensive herbal supplement can be considered a therapeutic solution in these patients.https://ajp.mums.ac.ir/article_21512_deb5958f3d6d71af9ebf2e8e52dae51f.pdfdiabetes mellituscurcuminpiperinediabetic retinopathyocta |
| spellingShingle | Sepide Amini Amirhossein Sahebkar Alireza Dehghani Bijan Iraj Abdolreza Rezaeian-Ramsheh Gholamreza Askari Muhammed Majeed Mohammad Bagherniya The effect of curcumin-piperine on cardiometabolic, inflammatory and oxidative stress factors and macular vascular density in optical coherence tomography angiography (OCTA) in patients with non-proliferative diabetic retinopathy: Study protocol for a randomized, double-blind controlled trial Avicenna Journal of Phytomedicine diabetes mellitus curcumin piperine diabetic retinopathy octa |
| title | The effect of curcumin-piperine on cardiometabolic, inflammatory and oxidative stress factors and macular vascular density in optical coherence tomography angiography (OCTA) in patients with non-proliferative diabetic retinopathy: Study protocol for a randomized, double-blind controlled trial |
| title_full | The effect of curcumin-piperine on cardiometabolic, inflammatory and oxidative stress factors and macular vascular density in optical coherence tomography angiography (OCTA) in patients with non-proliferative diabetic retinopathy: Study protocol for a randomized, double-blind controlled trial |
| title_fullStr | The effect of curcumin-piperine on cardiometabolic, inflammatory and oxidative stress factors and macular vascular density in optical coherence tomography angiography (OCTA) in patients with non-proliferative diabetic retinopathy: Study protocol for a randomized, double-blind controlled trial |
| title_full_unstemmed | The effect of curcumin-piperine on cardiometabolic, inflammatory and oxidative stress factors and macular vascular density in optical coherence tomography angiography (OCTA) in patients with non-proliferative diabetic retinopathy: Study protocol for a randomized, double-blind controlled trial |
| title_short | The effect of curcumin-piperine on cardiometabolic, inflammatory and oxidative stress factors and macular vascular density in optical coherence tomography angiography (OCTA) in patients with non-proliferative diabetic retinopathy: Study protocol for a randomized, double-blind controlled trial |
| title_sort | effect of curcumin piperine on cardiometabolic inflammatory and oxidative stress factors and macular vascular density in optical coherence tomography angiography octa in patients with non proliferative diabetic retinopathy study protocol for a randomized double blind controlled trial |
| topic | diabetes mellitus curcumin piperine diabetic retinopathy octa |
| url | https://ajp.mums.ac.ir/article_21512_deb5958f3d6d71af9ebf2e8e52dae51f.pdf |
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