Acute exercise decreases vaccine reactions following influenza vaccination among older adults
Although valuable and effective in decreasing disease burden, influenza vaccination has low rates of efficacy, especially in those at most risk. Studies have shown that acute exercise can improve vaccine responses, most consistently with weaker antigens. Here we examined the effect of resistance exe...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-01-01
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| Series: | Brain, Behavior, & Immunity - Health |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666354619300092 |
| _version_ | 1819098544735256576 |
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| author | Erika Bohn-Goldbaum April Pascoe Maria Fiatarone Singh Nalin Singh Jen Kok Dominic E. Dwyer Elizabeth Mathieson Robert Booy Kate M. Edwards |
| author_facet | Erika Bohn-Goldbaum April Pascoe Maria Fiatarone Singh Nalin Singh Jen Kok Dominic E. Dwyer Elizabeth Mathieson Robert Booy Kate M. Edwards |
| author_sort | Erika Bohn-Goldbaum |
| collection | DOAJ |
| description | Although valuable and effective in decreasing disease burden, influenza vaccination has low rates of efficacy, especially in those at most risk. Studies have shown that acute exercise can improve vaccine responses, most consistently with weaker antigens. Here we examined the effect of resistance exercise on the acute and longer-term responses to influenza vaccination among healthy older adults. Forty-six participants (47.8% male, mean 73.4 ± 6.6 years) were randomised to perform one 45-min moderate-intensity resistance exercise session or sit quietly prior to the receipt of influenza vaccination.Acute exercise reduced vaccine reactions but had no effect on either antibody responses or development of influenza-like symptoms during six months of follow-up. Psychosocial and behavioural characteristics were examined for potential associations with the responses to vaccination. Participants (n = 36) vaccinated in the previous year had higher baseline antibody titres but not follow-up titres nor more frequent experience of influenza-like symptoms over 6 months compared to those unvaccinated in the previous year. These findings provide further support for the ability of acute exercise to reduce vaccine reactions and suggest risk factors for vaccine responses for future exploration. |
| first_indexed | 2024-12-22T00:32:41Z |
| format | Article |
| id | doaj.art-0726efb2ca5a442ea358605edf91c921 |
| institution | Directory Open Access Journal |
| issn | 2666-3546 |
| language | English |
| last_indexed | 2024-12-22T00:32:41Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain, Behavior, & Immunity - Health |
| spelling | doaj.art-0726efb2ca5a442ea358605edf91c9212022-12-21T18:44:54ZengElsevierBrain, Behavior, & Immunity - Health2666-35462020-01-011100009Acute exercise decreases vaccine reactions following influenza vaccination among older adultsErika Bohn-Goldbaum0April Pascoe1Maria Fiatarone Singh2Nalin Singh3Jen Kok4Dominic E. Dwyer5Elizabeth Mathieson6Robert Booy7Kate M. Edwards8The University of Sydney, Faculty of Health Sciences and Charles Perkins Centre, Sydney, Australia; Corresponding author.The University of Sydney, Faculty of Health Sciences and Charles Perkins Centre, Sydney, AustraliaThe University of Sydney, Faculty of Health Sciences and Charles Perkins Centre, Sydney, Australia; The University of Sydney, Faculty of Health Sciences, Physical Activity, Lifestyle, Ageing and Wellbeing Research Group, Lidcombe, Australia; Hebrew SeniorLife and Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USAThe Centre for STRONG Medicine, Pymble, NSW, AustraliaInstitute for Clinical Pathology and Medical Research, NSW Health Pathology, Westmead Hospital and University of Sydney, Sydney, AustraliaInstitute for Clinical Pathology and Medical Research, NSW Health Pathology, Westmead Hospital and University of Sydney, Sydney, AustraliaThe Centre for STRONG Medicine, Balmain Hospital, Balmain, NSW, AustraliaThe University of Sydney, National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases, Sydney, AustraliaThe University of Sydney, Faculty of Health Sciences and Charles Perkins Centre, Sydney, AustraliaAlthough valuable and effective in decreasing disease burden, influenza vaccination has low rates of efficacy, especially in those at most risk. Studies have shown that acute exercise can improve vaccine responses, most consistently with weaker antigens. Here we examined the effect of resistance exercise on the acute and longer-term responses to influenza vaccination among healthy older adults. Forty-six participants (47.8% male, mean 73.4 ± 6.6 years) were randomised to perform one 45-min moderate-intensity resistance exercise session or sit quietly prior to the receipt of influenza vaccination.Acute exercise reduced vaccine reactions but had no effect on either antibody responses or development of influenza-like symptoms during six months of follow-up. Psychosocial and behavioural characteristics were examined for potential associations with the responses to vaccination. Participants (n = 36) vaccinated in the previous year had higher baseline antibody titres but not follow-up titres nor more frequent experience of influenza-like symptoms over 6 months compared to those unvaccinated in the previous year. These findings provide further support for the ability of acute exercise to reduce vaccine reactions and suggest risk factors for vaccine responses for future exploration.http://www.sciencedirect.com/science/article/pii/S2666354619300092Acute exerciseVaccinationImmune functionOlder adults |
| spellingShingle | Erika Bohn-Goldbaum April Pascoe Maria Fiatarone Singh Nalin Singh Jen Kok Dominic E. Dwyer Elizabeth Mathieson Robert Booy Kate M. Edwards Acute exercise decreases vaccine reactions following influenza vaccination among older adults Brain, Behavior, & Immunity - Health Acute exercise Vaccination Immune function Older adults |
| title | Acute exercise decreases vaccine reactions following influenza vaccination among older adults |
| title_full | Acute exercise decreases vaccine reactions following influenza vaccination among older adults |
| title_fullStr | Acute exercise decreases vaccine reactions following influenza vaccination among older adults |
| title_full_unstemmed | Acute exercise decreases vaccine reactions following influenza vaccination among older adults |
| title_short | Acute exercise decreases vaccine reactions following influenza vaccination among older adults |
| title_sort | acute exercise decreases vaccine reactions following influenza vaccination among older adults |
| topic | Acute exercise Vaccination Immune function Older adults |
| url | http://www.sciencedirect.com/science/article/pii/S2666354619300092 |
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