Case Report: Response to Immunotherapy and Anti-Androgen Therapy in Male Occult Triple-Negative Breast Cancer
Male occult triple-negative breast cancer (TNBC) is an exceedingly rare form of breast cancer, and prospective information regarding its management is therefore lacking. Current treatment strategies are largely extrapolated from clinical trials of female breast cancer, leading to substantial knowled...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.840453/full |
| _version_ | 1811260587962793984 |
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| author | Xin-Hua Wang Jing Zhang Jie Wu Xiao-Han He Yan-Ru Shen Yong-Gang Peng Yu-Zhi An |
| author_facet | Xin-Hua Wang Jing Zhang Jie Wu Xiao-Han He Yan-Ru Shen Yong-Gang Peng Yu-Zhi An |
| author_sort | Xin-Hua Wang |
| collection | DOAJ |
| description | Male occult triple-negative breast cancer (TNBC) is an exceedingly rare form of breast cancer, and prospective information regarding its management is therefore lacking. Current treatment strategies are largely extrapolated from clinical trials of female breast cancer, leading to substantial knowledge gaps concerning the optimal management of male breast cancer. Here, we present a male patient with occult TNBC who responded to immunotherapy, with an obvious reduction in his tumor burden following antiandrogen therapy, after heavy treatment with several lines of chemotherapy. This case highlights the potential efficacy of immunotherapy in cases of male TNBC and suggests a role for antiandrogen therapy in managing patients with luminal androgen receptor-positive TNBC. |
| first_indexed | 2024-04-12T18:49:44Z |
| format | Article |
| id | doaj.art-072e54b9f1964d889e383144919ea767 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-12T18:49:44Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-072e54b9f1964d889e383144919ea7672022-12-22T03:20:30ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-03-011210.3389/fonc.2022.840453840453Case Report: Response to Immunotherapy and Anti-Androgen Therapy in Male Occult Triple-Negative Breast CancerXin-Hua Wang0Jing Zhang1Jie Wu2Xiao-Han He3Yan-Ru Shen4Yong-Gang Peng5Yu-Zhi An6Department of Oncology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, ChinaDepartment of Oncology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, ChinaDepartment of Oncology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, ChinaDepartment of Medical Science, Berry Oncology Corporation, Beijing, ChinaDepartment of Medical Science, Berry Oncology Corporation, Beijing, ChinaDepartment of Medical Science, Berry Oncology Corporation, Beijing, ChinaDepartment of Oncology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, ChinaMale occult triple-negative breast cancer (TNBC) is an exceedingly rare form of breast cancer, and prospective information regarding its management is therefore lacking. Current treatment strategies are largely extrapolated from clinical trials of female breast cancer, leading to substantial knowledge gaps concerning the optimal management of male breast cancer. Here, we present a male patient with occult TNBC who responded to immunotherapy, with an obvious reduction in his tumor burden following antiandrogen therapy, after heavy treatment with several lines of chemotherapy. This case highlights the potential efficacy of immunotherapy in cases of male TNBC and suggests a role for antiandrogen therapy in managing patients with luminal androgen receptor-positive TNBC.https://www.frontiersin.org/articles/10.3389/fonc.2022.840453/fullmale breast canceroccult breast cancerimmunothearpyantiandrogen therapycase report |
| spellingShingle | Xin-Hua Wang Jing Zhang Jie Wu Xiao-Han He Yan-Ru Shen Yong-Gang Peng Yu-Zhi An Case Report: Response to Immunotherapy and Anti-Androgen Therapy in Male Occult Triple-Negative Breast Cancer Frontiers in Oncology male breast cancer occult breast cancer immunothearpy antiandrogen therapy case report |
| title | Case Report: Response to Immunotherapy and Anti-Androgen Therapy in Male Occult Triple-Negative Breast Cancer |
| title_full | Case Report: Response to Immunotherapy and Anti-Androgen Therapy in Male Occult Triple-Negative Breast Cancer |
| title_fullStr | Case Report: Response to Immunotherapy and Anti-Androgen Therapy in Male Occult Triple-Negative Breast Cancer |
| title_full_unstemmed | Case Report: Response to Immunotherapy and Anti-Androgen Therapy in Male Occult Triple-Negative Breast Cancer |
| title_short | Case Report: Response to Immunotherapy and Anti-Androgen Therapy in Male Occult Triple-Negative Breast Cancer |
| title_sort | case report response to immunotherapy and anti androgen therapy in male occult triple negative breast cancer |
| topic | male breast cancer occult breast cancer immunothearpy antiandrogen therapy case report |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.840453/full |
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