Triple, simultaneous, very late coronary stent thrombosis
Coronary artery stent thrombosis is an uncommon but potentially catastrophic complication. The risk of very late stent thrombosis (VLST) raises important safety issues regarding the first generation of drug-eluting stents (DES). Although several complex mechanisms for VLST have been suggested and va...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2013-03-01
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| Series: | Revista Portuguesa de Cardiologia |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0870255113000243 |
| _version_ | 1819146221628948480 |
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| author | Miguel Silva Vieira André Luz Diana Anjo Nuno Antunes Mário Santos Henrique Carvalho Severo Torres |
| author_facet | Miguel Silva Vieira André Luz Diana Anjo Nuno Antunes Mário Santos Henrique Carvalho Severo Torres |
| author_sort | Miguel Silva Vieira |
| collection | DOAJ |
| description | Coronary artery stent thrombosis is an uncommon but potentially catastrophic complication. The risk of very late stent thrombosis (VLST) raises important safety issues regarding the first generation of drug-eluting stents (DES). Although several complex mechanisms for VLST have been suggested and various predictors have been described, its pathophysiology is not completely understood and it is not known whether longer-term dual antiplatelet therapy reduces the risk. We present a rare case of simultaneous very late DES thrombosis in the three vascular territories, following discontinuation of antiplatelet therapy seven years after stent placement, presenting as cardiogenic shock. Resumo: A trombose de stent coronário é uma complicação rara mas potencialmente catastrófica. O risco de trombose muito tardia de stent (TMTS) tem levantado questões importantes sobre a segurança do uso de stents revestidos com fármacos (SRF) de primeira geração. Embora sejam vários e complexos os mecanismos da TMTS e vários os preditores que têm sido descritos, a sua fisiopatologia ainda não está totalmente esclarecida e desconhece-se se o prolongar da terapêutica antiagregante dupla reduz esse risco. Descrevemos um caso raro de trombose muito tardia de SRF ocorrendo em simultâneo nos três territórios vasculares, após interrupção da terapêutica antiagregante, sete anos após implantação dos stents, apresentando-se como choque cardiogénico. Keywords: Very late stent thrombosis, Drug-eluting stents, Palavras-chave: Trombose muito tardia de stent, Stents revestidos |
| first_indexed | 2024-12-22T13:10:29Z |
| format | Article |
| id | doaj.art-0730d399f27a41b1af2fec666dadc214 |
| institution | Directory Open Access Journal |
| issn | 0870-2551 |
| language | English |
| last_indexed | 2024-12-22T13:10:29Z |
| publishDate | 2013-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Revista Portuguesa de Cardiologia |
| spelling | doaj.art-0730d399f27a41b1af2fec666dadc2142022-12-21T18:24:45ZengElsevierRevista Portuguesa de Cardiologia0870-25512013-03-01323247252Triple, simultaneous, very late coronary stent thrombosisMiguel Silva Vieira0André Luz1Diana Anjo2Nuno Antunes3Mário Santos4Henrique Carvalho5Severo Torres6Corresponding author.; Cardiology Department, Santo António Hospital– Centro Hospitalar do Porto, Porto, PortugalCardiology Department, Santo António Hospital– Centro Hospitalar do Porto, Porto, PortugalCardiology Department, Santo António Hospital– Centro Hospitalar do Porto, Porto, PortugalCardiology Department, Santo António Hospital– Centro Hospitalar do Porto, Porto, PortugalCardiology Department, Santo António Hospital– Centro Hospitalar do Porto, Porto, PortugalCardiology Department, Santo António Hospital– Centro Hospitalar do Porto, Porto, PortugalCardiology Department, Santo António Hospital– Centro Hospitalar do Porto, Porto, PortugalCoronary artery stent thrombosis is an uncommon but potentially catastrophic complication. The risk of very late stent thrombosis (VLST) raises important safety issues regarding the first generation of drug-eluting stents (DES). Although several complex mechanisms for VLST have been suggested and various predictors have been described, its pathophysiology is not completely understood and it is not known whether longer-term dual antiplatelet therapy reduces the risk. We present a rare case of simultaneous very late DES thrombosis in the three vascular territories, following discontinuation of antiplatelet therapy seven years after stent placement, presenting as cardiogenic shock. Resumo: A trombose de stent coronário é uma complicação rara mas potencialmente catastrófica. O risco de trombose muito tardia de stent (TMTS) tem levantado questões importantes sobre a segurança do uso de stents revestidos com fármacos (SRF) de primeira geração. Embora sejam vários e complexos os mecanismos da TMTS e vários os preditores que têm sido descritos, a sua fisiopatologia ainda não está totalmente esclarecida e desconhece-se se o prolongar da terapêutica antiagregante dupla reduz esse risco. Descrevemos um caso raro de trombose muito tardia de SRF ocorrendo em simultâneo nos três territórios vasculares, após interrupção da terapêutica antiagregante, sete anos após implantação dos stents, apresentando-se como choque cardiogénico. Keywords: Very late stent thrombosis, Drug-eluting stents, Palavras-chave: Trombose muito tardia de stent, Stents revestidoshttp://www.sciencedirect.com/science/article/pii/S0870255113000243 |
| spellingShingle | Miguel Silva Vieira André Luz Diana Anjo Nuno Antunes Mário Santos Henrique Carvalho Severo Torres Triple, simultaneous, very late coronary stent thrombosis Revista Portuguesa de Cardiologia |
| title | Triple, simultaneous, very late coronary stent thrombosis |
| title_full | Triple, simultaneous, very late coronary stent thrombosis |
| title_fullStr | Triple, simultaneous, very late coronary stent thrombosis |
| title_full_unstemmed | Triple, simultaneous, very late coronary stent thrombosis |
| title_short | Triple, simultaneous, very late coronary stent thrombosis |
| title_sort | triple simultaneous very late coronary stent thrombosis |
| url | http://www.sciencedirect.com/science/article/pii/S0870255113000243 |
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