Epigenetic Mechanisms of ART-Related Imprinting Disorders: Lessons From iPSC and Mouse Models
The rising frequency of ART-conceived births is accompanied by the need for an improved understanding of the implications of ART on gametes and embryos. Increasing evidence from mouse models and human epidemiological data suggests that ART procedures may play a role in the pathophysiology of certain...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/12/11/1704 |
| _version_ | 1797510198250700800 |
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| author | Alex Horánszky Jessica L. Becker Melinda Zana Anne C. Ferguson-Smith András Dinnyés |
| author_facet | Alex Horánszky Jessica L. Becker Melinda Zana Anne C. Ferguson-Smith András Dinnyés |
| author_sort | Alex Horánszky |
| collection | DOAJ |
| description | The rising frequency of ART-conceived births is accompanied by the need for an improved understanding of the implications of ART on gametes and embryos. Increasing evidence from mouse models and human epidemiological data suggests that ART procedures may play a role in the pathophysiology of certain imprinting disorders (IDs), including Beckwith-Wiedemann syndrome, Silver-Russell syndrome, Prader-Willi syndrome, and Angelman syndrome. The underlying molecular basis of this association, however, requires further elucidation. In this review, we discuss the epigenetic and imprinting alterations of in vivo mouse models and human iPSC models of ART. Mouse models have demonstrated aberrant regulation of imprinted genes involved with ART-related IDs. In the past decade, iPSC technology has provided a platform for patient-specific cellular models of culture-associated perturbed imprinting. However, despite ongoing efforts, a deeper understanding of the susceptibility of iPSCs to epigenetic perturbation is required if they are to be reliably used for modelling ART-associated IDs. Comparing the patterns of susceptibility of imprinted genes in mouse models and IPSCs in culture improves the current understanding of the underlying mechanisms of ART-linked IDs with implications for our understanding of the influence of environmental factors such as culture and hormone treatments on epigenetically important regions of the genome such as imprints. |
| first_indexed | 2024-03-10T05:28:12Z |
| format | Article |
| id | doaj.art-073101edb9684d6f9c6ffca73a21cc5d |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-10T05:28:12Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-073101edb9684d6f9c6ffca73a21cc5d2023-11-22T23:27:34ZengMDPI AGGenes2073-44252021-10-011211170410.3390/genes12111704Epigenetic Mechanisms of ART-Related Imprinting Disorders: Lessons From iPSC and Mouse ModelsAlex Horánszky0Jessica L. Becker1Melinda Zana2Anne C. Ferguson-Smith3András Dinnyés4BioTalentum Ltd., H-2100 Gödöllő, HungaryDepartment of Genetics, University of Cambridge, Cambridge CB2 3EH, UKBioTalentum Ltd., H-2100 Gödöllő, HungaryDepartment of Genetics, University of Cambridge, Cambridge CB2 3EH, UKBioTalentum Ltd., H-2100 Gödöllő, HungaryThe rising frequency of ART-conceived births is accompanied by the need for an improved understanding of the implications of ART on gametes and embryos. Increasing evidence from mouse models and human epidemiological data suggests that ART procedures may play a role in the pathophysiology of certain imprinting disorders (IDs), including Beckwith-Wiedemann syndrome, Silver-Russell syndrome, Prader-Willi syndrome, and Angelman syndrome. The underlying molecular basis of this association, however, requires further elucidation. In this review, we discuss the epigenetic and imprinting alterations of in vivo mouse models and human iPSC models of ART. Mouse models have demonstrated aberrant regulation of imprinted genes involved with ART-related IDs. In the past decade, iPSC technology has provided a platform for patient-specific cellular models of culture-associated perturbed imprinting. However, despite ongoing efforts, a deeper understanding of the susceptibility of iPSCs to epigenetic perturbation is required if they are to be reliably used for modelling ART-associated IDs. Comparing the patterns of susceptibility of imprinted genes in mouse models and IPSCs in culture improves the current understanding of the underlying mechanisms of ART-linked IDs with implications for our understanding of the influence of environmental factors such as culture and hormone treatments on epigenetically important regions of the genome such as imprints.https://www.mdpi.com/2073-4425/12/11/1704genomic imprintingimprinting disordersassisted reproductive technologyDNA methylationmouse modelsiPSCs |
| spellingShingle | Alex Horánszky Jessica L. Becker Melinda Zana Anne C. Ferguson-Smith András Dinnyés Epigenetic Mechanisms of ART-Related Imprinting Disorders: Lessons From iPSC and Mouse Models Genes genomic imprinting imprinting disorders assisted reproductive technology DNA methylation mouse models iPSCs |
| title | Epigenetic Mechanisms of ART-Related Imprinting Disorders: Lessons From iPSC and Mouse Models |
| title_full | Epigenetic Mechanisms of ART-Related Imprinting Disorders: Lessons From iPSC and Mouse Models |
| title_fullStr | Epigenetic Mechanisms of ART-Related Imprinting Disorders: Lessons From iPSC and Mouse Models |
| title_full_unstemmed | Epigenetic Mechanisms of ART-Related Imprinting Disorders: Lessons From iPSC and Mouse Models |
| title_short | Epigenetic Mechanisms of ART-Related Imprinting Disorders: Lessons From iPSC and Mouse Models |
| title_sort | epigenetic mechanisms of art related imprinting disorders lessons from ipsc and mouse models |
| topic | genomic imprinting imprinting disorders assisted reproductive technology DNA methylation mouse models iPSCs |
| url | https://www.mdpi.com/2073-4425/12/11/1704 |
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