Microbial Metabolites in Multiple Sclerosis: Implications for Pathogenesis and Treatment
Metabolites produced by the gut microbiota have been shown to play an important role in numerous inflammatory, neuropsychiatric, and neurodegenerative diseases. Specifically, microbial metabolites have been implicated in the modulation of innate and adaptive immunity, especially in the generation of...
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Format: | Article |
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Frontiers Media S.A.
2022-04-01
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Series: | Frontiers in Neuroscience |
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Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2022.885031/full |
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author | Eduardo Duarte-Silva Eduardo Duarte-Silva Eduardo Duarte-Silva Eduardo Duarte-Silva Sven G. Meuth Christina Alves Peixoto Christina Alves Peixoto |
author_facet | Eduardo Duarte-Silva Eduardo Duarte-Silva Eduardo Duarte-Silva Eduardo Duarte-Silva Sven G. Meuth Christina Alves Peixoto Christina Alves Peixoto |
author_sort | Eduardo Duarte-Silva |
collection | DOAJ |
description | Metabolites produced by the gut microbiota have been shown to play an important role in numerous inflammatory, neuropsychiatric, and neurodegenerative diseases. Specifically, microbial metabolites have been implicated in the modulation of innate and adaptive immunity, especially in the generation of regulatory T cells (Tregs), which are key regulators of multiple sclerosis (MS) pathogenesis. Furthermore, they affect processes relevant to MS pathophysiology, such as inflammation and demyelination, which makes them attractive molecules to be explored as therapeutics in MS. In this review, we discuss the importance of these metabolites as factors contributing to disease pathogenesis and as therapeutic targets in MS. Establishing an improved understanding of these gut-microbiota derived metabolites may provide new avenues for the treatment of MS. |
first_indexed | 2024-04-13T03:39:54Z |
format | Article |
id | doaj.art-07323b681eb848cabbe4a4e78d92c39a |
institution | Directory Open Access Journal |
issn | 1662-453X |
language | English |
last_indexed | 2024-04-13T03:39:54Z |
publishDate | 2022-04-01 |
publisher | Frontiers Media S.A. |
record_format | Article |
series | Frontiers in Neuroscience |
spelling | doaj.art-07323b681eb848cabbe4a4e78d92c39a2022-12-22T03:04:10ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2022-04-011610.3389/fnins.2022.885031885031Microbial Metabolites in Multiple Sclerosis: Implications for Pathogenesis and TreatmentEduardo Duarte-Silva0Eduardo Duarte-Silva1Eduardo Duarte-Silva2Eduardo Duarte-Silva3Sven G. Meuth4Christina Alves Peixoto5Christina Alves Peixoto6Laboratory of Ultrastructure, Aggeu Magalhães Institute (IAM), Recife, BrazilPostgraduate Program in Biosciences and Biotechnology for Health (PPGBBS), Oswaldo Cruz Foundation (FIOCRUZ-PE)/Aggeu Magalhães Institute (IAM), Recife, BrazilNetwork of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Recife, BrazilDepartment of Neurology, Medical Faculty, University Hospital Düsseldorf, Düsseldorf, GermanyDepartment of Neurology, Medical Faculty, University Hospital Düsseldorf, Düsseldorf, GermanyLaboratory of Ultrastructure, Aggeu Magalhães Institute (IAM), Recife, BrazilNational Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, BrazilMetabolites produced by the gut microbiota have been shown to play an important role in numerous inflammatory, neuropsychiatric, and neurodegenerative diseases. Specifically, microbial metabolites have been implicated in the modulation of innate and adaptive immunity, especially in the generation of regulatory T cells (Tregs), which are key regulators of multiple sclerosis (MS) pathogenesis. Furthermore, they affect processes relevant to MS pathophysiology, such as inflammation and demyelination, which makes them attractive molecules to be explored as therapeutics in MS. In this review, we discuss the importance of these metabolites as factors contributing to disease pathogenesis and as therapeutic targets in MS. Establishing an improved understanding of these gut-microbiota derived metabolites may provide new avenues for the treatment of MS.https://www.frontiersin.org/articles/10.3389/fnins.2022.885031/fullexperimental autoimmune encephalomyelitis (EAE)multiple sclerosis (MS)short-chain fatty acidsurolithinspolyaminesgut microbiota-derived metabolites |
spellingShingle | Eduardo Duarte-Silva Eduardo Duarte-Silva Eduardo Duarte-Silva Eduardo Duarte-Silva Sven G. Meuth Christina Alves Peixoto Christina Alves Peixoto Microbial Metabolites in Multiple Sclerosis: Implications for Pathogenesis and Treatment Frontiers in Neuroscience experimental autoimmune encephalomyelitis (EAE) multiple sclerosis (MS) short-chain fatty acids urolithins polyamines gut microbiota-derived metabolites |
title | Microbial Metabolites in Multiple Sclerosis: Implications for Pathogenesis and Treatment |
title_full | Microbial Metabolites in Multiple Sclerosis: Implications for Pathogenesis and Treatment |
title_fullStr | Microbial Metabolites in Multiple Sclerosis: Implications for Pathogenesis and Treatment |
title_full_unstemmed | Microbial Metabolites in Multiple Sclerosis: Implications for Pathogenesis and Treatment |
title_short | Microbial Metabolites in Multiple Sclerosis: Implications for Pathogenesis and Treatment |
title_sort | microbial metabolites in multiple sclerosis implications for pathogenesis and treatment |
topic | experimental autoimmune encephalomyelitis (EAE) multiple sclerosis (MS) short-chain fatty acids urolithins polyamines gut microbiota-derived metabolites |
url | https://www.frontiersin.org/articles/10.3389/fnins.2022.885031/full |
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