Risk factors for acute Toxoplasma gondii diseases in Taiwan: a population-based case-control study.
Although human toxoplasmosis is a notifiable disease in Taiwan since 2007, little is known about its risk factors. This study aimed to investigate the risk factors for acute Toxoplasma gondii diseases in Taiwan. We conducted a nationwide population-based case-control study. Cases of acute human toxo...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3946628?pdf=render |
| _version_ | 1828756774600048640 |
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| author | Ting-Yi Chiang Ming-Chu Kuo Chang-Hsun Chen Jyh-Yuan Yang Cheng-Feng Kao Dar-Der Ji Chi-Tai Fang |
| author_facet | Ting-Yi Chiang Ming-Chu Kuo Chang-Hsun Chen Jyh-Yuan Yang Cheng-Feng Kao Dar-Der Ji Chi-Tai Fang |
| author_sort | Ting-Yi Chiang |
| collection | DOAJ |
| description | Although human toxoplasmosis is a notifiable disease in Taiwan since 2007, little is known about its risk factors. This study aimed to investigate the risk factors for acute Toxoplasma gondii diseases in Taiwan. We conducted a nationwide population-based case-control study. Cases of acute human toxoplasmosis notified to the Taiwan Centers for Diseases Control (Taipei, Taiwan) during 2008-2013 were compared with controls that were randomly selected from healthy T. gondii-seronegative blood donors who participated in a nationwide T. gondii seroepidemiologic study during 2009-2010. Cases and controls were matched according to age, gender and residency at an 1:8 ratio. Structured questionnaires were used to gather information regarding risk factors. A total of 30 laboratory-confirmed acute T. gondii disease cases and 224 controls were enrolled. The most common clinical manifestation of the cases was flu-like symptoms (n = 20), followed by central nervous system disease (n = 4), ocular diseases (n = 3), abortion (n = 2), and congenital infection (n = 1). Multivariate conditional logistic regression showed that raw clam consumption (adjusted odds ratio [OR] = 3.7; 95% confidence interval [CI] = 1.4-9.9) and having a cat in the household (adjusted OR = 2.9; 95% CI = 1.1-7.9) were two independent risk factors for acute T. gondii disease. We conclude that raw shellfish consumption and domestic cat exposure were risk factors for acquiring acute T. gondii diseases in Taiwan. This finding may guide future research and control policies. |
| first_indexed | 2024-12-10T23:21:38Z |
| format | Article |
| id | doaj.art-0732a39d02ab4766a41fcd857546d692 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T23:21:38Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-0732a39d02ab4766a41fcd857546d6922022-12-22T01:29:41ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0193e9088010.1371/journal.pone.0090880Risk factors for acute Toxoplasma gondii diseases in Taiwan: a population-based case-control study.Ting-Yi ChiangMing-Chu KuoChang-Hsun ChenJyh-Yuan YangCheng-Feng KaoDar-Der JiChi-Tai FangAlthough human toxoplasmosis is a notifiable disease in Taiwan since 2007, little is known about its risk factors. This study aimed to investigate the risk factors for acute Toxoplasma gondii diseases in Taiwan. We conducted a nationwide population-based case-control study. Cases of acute human toxoplasmosis notified to the Taiwan Centers for Diseases Control (Taipei, Taiwan) during 2008-2013 were compared with controls that were randomly selected from healthy T. gondii-seronegative blood donors who participated in a nationwide T. gondii seroepidemiologic study during 2009-2010. Cases and controls were matched according to age, gender and residency at an 1:8 ratio. Structured questionnaires were used to gather information regarding risk factors. A total of 30 laboratory-confirmed acute T. gondii disease cases and 224 controls were enrolled. The most common clinical manifestation of the cases was flu-like symptoms (n = 20), followed by central nervous system disease (n = 4), ocular diseases (n = 3), abortion (n = 2), and congenital infection (n = 1). Multivariate conditional logistic regression showed that raw clam consumption (adjusted odds ratio [OR] = 3.7; 95% confidence interval [CI] = 1.4-9.9) and having a cat in the household (adjusted OR = 2.9; 95% CI = 1.1-7.9) were two independent risk factors for acute T. gondii disease. We conclude that raw shellfish consumption and domestic cat exposure were risk factors for acquiring acute T. gondii diseases in Taiwan. This finding may guide future research and control policies.http://europepmc.org/articles/PMC3946628?pdf=render |
| spellingShingle | Ting-Yi Chiang Ming-Chu Kuo Chang-Hsun Chen Jyh-Yuan Yang Cheng-Feng Kao Dar-Der Ji Chi-Tai Fang Risk factors for acute Toxoplasma gondii diseases in Taiwan: a population-based case-control study. PLoS ONE |
| title | Risk factors for acute Toxoplasma gondii diseases in Taiwan: a population-based case-control study. |
| title_full | Risk factors for acute Toxoplasma gondii diseases in Taiwan: a population-based case-control study. |
| title_fullStr | Risk factors for acute Toxoplasma gondii diseases in Taiwan: a population-based case-control study. |
| title_full_unstemmed | Risk factors for acute Toxoplasma gondii diseases in Taiwan: a population-based case-control study. |
| title_short | Risk factors for acute Toxoplasma gondii diseases in Taiwan: a population-based case-control study. |
| title_sort | risk factors for acute toxoplasma gondii diseases in taiwan a population based case control study |
| url | http://europepmc.org/articles/PMC3946628?pdf=render |
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