A Multiple-Stimuli-Responsive Amphiphilic Copolymer for Antifouling and Antibacterial Functionality via a “Resistance–Kill–Release” Mechanism
In recent years, polymers with stimuli-responsive properties have been increasingly reported on due to their diverse applications. However, most of the studies have only focused on the performance of polymers under specific scenarios. The laws of changes in the properties in response to various exte...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/16/5059 |
| _version_ | 1797443197446651904 |
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| author | Xiaohan Liao Kai Niu Feng Liu Yongming Zhang |
| author_facet | Xiaohan Liao Kai Niu Feng Liu Yongming Zhang |
| author_sort | Xiaohan Liao |
| collection | DOAJ |
| description | In recent years, polymers with stimuli-responsive properties have been increasingly reported on due to their diverse applications. However, most of the studies have only focused on the performance of polymers under specific scenarios. The laws of changes in the properties in response to various external stimuli have been less systematically and quantitatively studied. In this paper, we prepared an amphiphilic polymer (PadaMX and PAdaM3QA−X) with temperature-, pH-, ion-, and β-cyclodextrin (β-CD)-responsive properties. According to the cloud point tested by the UV-Vis method, the lower critical soluble temperature (LCST) of PAdaM3QA−10% was more sensitive to a change in pH and less sensitive to a change in ions compared with PadaM3 due to quaternized side chains with a stronger intramolecular mutual repulsion. We then fabricated the coatings with responsive properties by immobilizing the adamantyl groups on β-CD-modified surfaces. The hydrophilicity of the coatings was improved after quaternization, as proven by the water contact angle (WCA) measurement. The antifouling and antibacterial performance was further evaluated via the fluorescence intensity of bovine serum albumin (BSA) adsorbed on the surfaces and the spread plate method. A 78.4% BSA desorption rate and a 96.8% sterilization rate were achieved by the PAdaM3QA−10% coating. In summary, this work prepared a multiple-stimuli-responsive amphiphilic copolymer for antifouling and antibacterial functionality via a “resistance–kill–release” mechanism. |
| first_indexed | 2024-03-09T12:52:33Z |
| format | Article |
| id | doaj.art-0733071f8b474ff7bda6ebd2af90717f |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T12:52:33Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-0733071f8b474ff7bda6ebd2af90717f2023-11-30T22:03:55ZengMDPI AGMolecules1420-30492022-08-012716505910.3390/molecules27165059A Multiple-Stimuli-Responsive Amphiphilic Copolymer for Antifouling and Antibacterial Functionality via a “Resistance–Kill–Release” MechanismXiaohan Liao0Kai Niu1Feng Liu2Yongming Zhang3School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, ChinaSchool of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, ChinaSchool of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, ChinaSchool of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, ChinaIn recent years, polymers with stimuli-responsive properties have been increasingly reported on due to their diverse applications. However, most of the studies have only focused on the performance of polymers under specific scenarios. The laws of changes in the properties in response to various external stimuli have been less systematically and quantitatively studied. In this paper, we prepared an amphiphilic polymer (PadaMX and PAdaM3QA−X) with temperature-, pH-, ion-, and β-cyclodextrin (β-CD)-responsive properties. According to the cloud point tested by the UV-Vis method, the lower critical soluble temperature (LCST) of PAdaM3QA−10% was more sensitive to a change in pH and less sensitive to a change in ions compared with PadaM3 due to quaternized side chains with a stronger intramolecular mutual repulsion. We then fabricated the coatings with responsive properties by immobilizing the adamantyl groups on β-CD-modified surfaces. The hydrophilicity of the coatings was improved after quaternization, as proven by the water contact angle (WCA) measurement. The antifouling and antibacterial performance was further evaluated via the fluorescence intensity of bovine serum albumin (BSA) adsorbed on the surfaces and the spread plate method. A 78.4% BSA desorption rate and a 96.8% sterilization rate were achieved by the PAdaM3QA−10% coating. In summary, this work prepared a multiple-stimuli-responsive amphiphilic copolymer for antifouling and antibacterial functionality via a “resistance–kill–release” mechanism.https://www.mdpi.com/1420-3049/27/16/5059stimuli-responsiveamphiphilic polymershost–guest interactionsantifoulingantibacterial |
| spellingShingle | Xiaohan Liao Kai Niu Feng Liu Yongming Zhang A Multiple-Stimuli-Responsive Amphiphilic Copolymer for Antifouling and Antibacterial Functionality via a “Resistance–Kill–Release” Mechanism Molecules stimuli-responsive amphiphilic polymers host–guest interactions antifouling antibacterial |
| title | A Multiple-Stimuli-Responsive Amphiphilic Copolymer for Antifouling and Antibacterial Functionality via a “Resistance–Kill–Release” Mechanism |
| title_full | A Multiple-Stimuli-Responsive Amphiphilic Copolymer for Antifouling and Antibacterial Functionality via a “Resistance–Kill–Release” Mechanism |
| title_fullStr | A Multiple-Stimuli-Responsive Amphiphilic Copolymer for Antifouling and Antibacterial Functionality via a “Resistance–Kill–Release” Mechanism |
| title_full_unstemmed | A Multiple-Stimuli-Responsive Amphiphilic Copolymer for Antifouling and Antibacterial Functionality via a “Resistance–Kill–Release” Mechanism |
| title_short | A Multiple-Stimuli-Responsive Amphiphilic Copolymer for Antifouling and Antibacterial Functionality via a “Resistance–Kill–Release” Mechanism |
| title_sort | multiple stimuli responsive amphiphilic copolymer for antifouling and antibacterial functionality via a resistance kill release mechanism |
| topic | stimuli-responsive amphiphilic polymers host–guest interactions antifouling antibacterial |
| url | https://www.mdpi.com/1420-3049/27/16/5059 |
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