Uncovering neural pathways underlying bulimia nervosa: resting-state neural connectivity disruptions correlate with maladaptive eating behaviors
Abstract Purpose Bulimia nervosa (BN) is characterized by recurrent binge-eating episodes and inappropriate compensatory behaviors. This study investigated alterations in resting-state surface-based neural activity in BN patients and explored correlations between brain activity and eating behavior....
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Springer
2023-10-01
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| Series: | Eating and Weight Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s40519-023-01617-5 |
| _version_ | 1827770776882774016 |
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| author | Jia-ni Wang Miao Wang Guo-wei Wu Wei-hua Li Zi-ling Lv Qian Chen Zheng-han Yang Xiao-hong Li Zhen-chang Wang Zhan-jiang Li Peng Zhang Li-rong Tang |
| author_facet | Jia-ni Wang Miao Wang Guo-wei Wu Wei-hua Li Zi-ling Lv Qian Chen Zheng-han Yang Xiao-hong Li Zhen-chang Wang Zhan-jiang Li Peng Zhang Li-rong Tang |
| author_sort | Jia-ni Wang |
| collection | DOAJ |
| description | Abstract Purpose Bulimia nervosa (BN) is characterized by recurrent binge-eating episodes and inappropriate compensatory behaviors. This study investigated alterations in resting-state surface-based neural activity in BN patients and explored correlations between brain activity and eating behavior. Methods A total of 26 BN patients and 28 healthy controls were enrolled. Indirect measurement of cerebral cortical activity and functional connectivity (FC) analyses were performed in Surfstat. A principal component analysis (PCA) model was used to capture the commonalities within the behavioral questionnaires from the BN group. Results Compared with the healthy control group, the BN group showed decreased surface-based two-dimensional regional homogeneity in the right superior parietal lobule (SPL). Additionally, the BN group showed decreased FC between the right SPL and the bilateral lingual gyrus and increased FC between the right SPL and the left caudate nucleus and right putamen. In the FC–behavior association analysis, the second principal component (PC2) was negatively correlated with FC between the right SPL and the left caudate nucleus. The third principal component (PC3) was negatively correlated with FC between the right SPL and the left lingual gyrus and positively correlated with FC between the right SPL and the right lingual gyrus. Conclusion We revealed that the right SPL undergoes reorganization with respect to specific brain regions at the whole-brain level in BN. In addition, our results suggest a correlation between brain reorganization and maladaptive eating behavior. These findings may provide useful information to better understand the neural mechanisms of BN. Level of evidence V, descriptive study. |
| first_indexed | 2024-03-11T12:44:21Z |
| format | Article |
| id | doaj.art-073465087d764394adbac32e1930e8d6 |
| institution | Directory Open Access Journal |
| issn | 1590-1262 |
| language | English |
| last_indexed | 2024-03-11T12:44:21Z |
| publishDate | 2023-10-01 |
| publisher | Springer |
| record_format | Article |
| series | Eating and Weight Disorders |
| spelling | doaj.art-073465087d764394adbac32e1930e8d62023-11-05T12:05:26ZengSpringerEating and Weight Disorders1590-12622023-10-0128111410.1007/s40519-023-01617-5Uncovering neural pathways underlying bulimia nervosa: resting-state neural connectivity disruptions correlate with maladaptive eating behaviorsJia-ni Wang0Miao Wang1Guo-wei Wu2Wei-hua Li3Zi-ling Lv4Qian Chen5Zheng-han Yang6Xiao-hong Li7Zhen-chang Wang8Zhan-jiang Li9Peng Zhang10Li-rong Tang11Department of Radiology, Beijing Friendship Hospital, Capital Medical UniversityChinese Institute for Brain ResearchCAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of SciencesDepartment of Radiology, Beijing Friendship Hospital, Capital Medical UniversityBeijing Anding Hospital, Capital Medical UniversityDepartment of Radiology, Beijing Friendship Hospital, Capital Medical UniversityDepartment of Radiology, Beijing Friendship Hospital, Capital Medical UniversityBeijing Anding Hospital, Capital Medical UniversityDepartment of Radiology, Beijing Friendship Hospital, Capital Medical UniversityBeijing Anding Hospital, Capital Medical UniversityDepartment of Radiology, Beijing Friendship Hospital, Capital Medical UniversityBeijing Anding Hospital, Capital Medical UniversityAbstract Purpose Bulimia nervosa (BN) is characterized by recurrent binge-eating episodes and inappropriate compensatory behaviors. This study investigated alterations in resting-state surface-based neural activity in BN patients and explored correlations between brain activity and eating behavior. Methods A total of 26 BN patients and 28 healthy controls were enrolled. Indirect measurement of cerebral cortical activity and functional connectivity (FC) analyses were performed in Surfstat. A principal component analysis (PCA) model was used to capture the commonalities within the behavioral questionnaires from the BN group. Results Compared with the healthy control group, the BN group showed decreased surface-based two-dimensional regional homogeneity in the right superior parietal lobule (SPL). Additionally, the BN group showed decreased FC between the right SPL and the bilateral lingual gyrus and increased FC between the right SPL and the left caudate nucleus and right putamen. In the FC–behavior association analysis, the second principal component (PC2) was negatively correlated with FC between the right SPL and the left caudate nucleus. The third principal component (PC3) was negatively correlated with FC between the right SPL and the left lingual gyrus and positively correlated with FC between the right SPL and the right lingual gyrus. Conclusion We revealed that the right SPL undergoes reorganization with respect to specific brain regions at the whole-brain level in BN. In addition, our results suggest a correlation between brain reorganization and maladaptive eating behavior. These findings may provide useful information to better understand the neural mechanisms of BN. Level of evidence V, descriptive study.https://doi.org/10.1007/s40519-023-01617-5Bulimia nervosaSurface-based regional homogeneityFunctional connectivityPrincipal component analysisEating behaviorVisual information |
| spellingShingle | Jia-ni Wang Miao Wang Guo-wei Wu Wei-hua Li Zi-ling Lv Qian Chen Zheng-han Yang Xiao-hong Li Zhen-chang Wang Zhan-jiang Li Peng Zhang Li-rong Tang Uncovering neural pathways underlying bulimia nervosa: resting-state neural connectivity disruptions correlate with maladaptive eating behaviors Eating and Weight Disorders Bulimia nervosa Surface-based regional homogeneity Functional connectivity Principal component analysis Eating behavior Visual information |
| title | Uncovering neural pathways underlying bulimia nervosa: resting-state neural connectivity disruptions correlate with maladaptive eating behaviors |
| title_full | Uncovering neural pathways underlying bulimia nervosa: resting-state neural connectivity disruptions correlate with maladaptive eating behaviors |
| title_fullStr | Uncovering neural pathways underlying bulimia nervosa: resting-state neural connectivity disruptions correlate with maladaptive eating behaviors |
| title_full_unstemmed | Uncovering neural pathways underlying bulimia nervosa: resting-state neural connectivity disruptions correlate with maladaptive eating behaviors |
| title_short | Uncovering neural pathways underlying bulimia nervosa: resting-state neural connectivity disruptions correlate with maladaptive eating behaviors |
| title_sort | uncovering neural pathways underlying bulimia nervosa resting state neural connectivity disruptions correlate with maladaptive eating behaviors |
| topic | Bulimia nervosa Surface-based regional homogeneity Functional connectivity Principal component analysis Eating behavior Visual information |
| url | https://doi.org/10.1007/s40519-023-01617-5 |
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