Sodium Fluorescein-Guided Surgery for Resection of Brain Metastases from Lung Cancer: A Consecutive Case Series Study and Literature Review
(1) Introduction and objective: Surgical resection plays an important role in the multidisciplinary treatment of lung cancer patients with brain metastases (BMs). Precisely distinguishing the tumor border intraoperatively to improve and maximize the extent of resection (EOR) without causing permanen...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/3/882 |
| _version_ | 1797624937314254848 |
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| author | Xing Cheng Jie Chen Ronghua Tang Jian Ruan Deqiang Mao Haifeng Yang |
| author_facet | Xing Cheng Jie Chen Ronghua Tang Jian Ruan Deqiang Mao Haifeng Yang |
| author_sort | Xing Cheng |
| collection | DOAJ |
| description | (1) Introduction and objective: Surgical resection plays an important role in the multidisciplinary treatment of lung cancer patients with brain metastases (BMs). Precisely distinguishing the tumor border intraoperatively to improve and maximize the extent of resection (EOR) without causing permanent neurological defects is crucial but still challenging. Therefore, we introduced our experience of utilizing sodium fluorescein (SF) in microneurosurgery of BMs from lung cancer. This study aims to evaluate whether the use of SF-guided surgery has a positive impact on postoperative outcomes. (2) Materials and methods: A retrospective study was performed to collect data on a consecutive case series of patients with BMs from lung cancer who underwent surgical resection from January 2020 to December 2021 at the Department of Neuro-Oncology, Chongqing University Cancer Hospital. A total of 52 patients were enrolled, of which 23 received SF-guided surgery and 29 did not. EOR was assessed pre- and postoperatively on T1 contrast-enhanced MRI. Clinical and epidemiological data as well as follow-up were gathered and analyzed. (3) Results: Compared with the non-SF-guided group, the SF-guided group revealed a significantly better EOR (87.0% vs. 62.1%) and a lower incidence of local recurrence (8.7% vs. 34.5%). Survival benefits were seen in patients with NSCLC, patients who were undergoing SF-guided surgery, and patients receiving postoperative systemic therapy. (4) Conclusions: SF-guiding under the YELLOW 560 nm filter is a safe and feasible tool for improving the EOR in patients with BMs from lung cancer, leading to better local recurrence control and prolonged survival. |
| first_indexed | 2024-03-11T09:49:44Z |
| format | Article |
| id | doaj.art-07373aeac56b4ebe8f3a506985d43e71 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T09:49:44Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-07373aeac56b4ebe8f3a506985d43e712023-11-16T16:18:36ZengMDPI AGCancers2072-66942023-01-0115388210.3390/cancers15030882Sodium Fluorescein-Guided Surgery for Resection of Brain Metastases from Lung Cancer: A Consecutive Case Series Study and Literature ReviewXing Cheng0Jie Chen1Ronghua Tang2Jian Ruan3Deqiang Mao4Haifeng Yang5Department of Neuro-Oncology, Chongqing University Cancer Hospital, Chongqing 400030, ChinaDepartment of Neuro-Oncology, Chongqing University Cancer Hospital, Chongqing 400030, ChinaDepartment of Neuro-Oncology, Chongqing University Cancer Hospital, Chongqing 400030, ChinaDepartment of Neuro-Oncology, Chongqing University Cancer Hospital, Chongqing 400030, ChinaDepartment of Neuro-Oncology, Chongqing University Cancer Hospital, Chongqing 400030, ChinaDepartment of Neuro-Oncology, Chongqing University Cancer Hospital, Chongqing 400030, China(1) Introduction and objective: Surgical resection plays an important role in the multidisciplinary treatment of lung cancer patients with brain metastases (BMs). Precisely distinguishing the tumor border intraoperatively to improve and maximize the extent of resection (EOR) without causing permanent neurological defects is crucial but still challenging. Therefore, we introduced our experience of utilizing sodium fluorescein (SF) in microneurosurgery of BMs from lung cancer. This study aims to evaluate whether the use of SF-guided surgery has a positive impact on postoperative outcomes. (2) Materials and methods: A retrospective study was performed to collect data on a consecutive case series of patients with BMs from lung cancer who underwent surgical resection from January 2020 to December 2021 at the Department of Neuro-Oncology, Chongqing University Cancer Hospital. A total of 52 patients were enrolled, of which 23 received SF-guided surgery and 29 did not. EOR was assessed pre- and postoperatively on T1 contrast-enhanced MRI. Clinical and epidemiological data as well as follow-up were gathered and analyzed. (3) Results: Compared with the non-SF-guided group, the SF-guided group revealed a significantly better EOR (87.0% vs. 62.1%) and a lower incidence of local recurrence (8.7% vs. 34.5%). Survival benefits were seen in patients with NSCLC, patients who were undergoing SF-guided surgery, and patients receiving postoperative systemic therapy. (4) Conclusions: SF-guiding under the YELLOW 560 nm filter is a safe and feasible tool for improving the EOR in patients with BMs from lung cancer, leading to better local recurrence control and prolonged survival.https://www.mdpi.com/2072-6694/15/3/882sodium fluoresceinbrain metastases from lung cancerfluorescence-guided surgeryextent of resection |
| spellingShingle | Xing Cheng Jie Chen Ronghua Tang Jian Ruan Deqiang Mao Haifeng Yang Sodium Fluorescein-Guided Surgery for Resection of Brain Metastases from Lung Cancer: A Consecutive Case Series Study and Literature Review Cancers sodium fluorescein brain metastases from lung cancer fluorescence-guided surgery extent of resection |
| title | Sodium Fluorescein-Guided Surgery for Resection of Brain Metastases from Lung Cancer: A Consecutive Case Series Study and Literature Review |
| title_full | Sodium Fluorescein-Guided Surgery for Resection of Brain Metastases from Lung Cancer: A Consecutive Case Series Study and Literature Review |
| title_fullStr | Sodium Fluorescein-Guided Surgery for Resection of Brain Metastases from Lung Cancer: A Consecutive Case Series Study and Literature Review |
| title_full_unstemmed | Sodium Fluorescein-Guided Surgery for Resection of Brain Metastases from Lung Cancer: A Consecutive Case Series Study and Literature Review |
| title_short | Sodium Fluorescein-Guided Surgery for Resection of Brain Metastases from Lung Cancer: A Consecutive Case Series Study and Literature Review |
| title_sort | sodium fluorescein guided surgery for resection of brain metastases from lung cancer a consecutive case series study and literature review |
| topic | sodium fluorescein brain metastases from lung cancer fluorescence-guided surgery extent of resection |
| url | https://www.mdpi.com/2072-6694/15/3/882 |
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