Risk factors for depression in patients with Parkinson's disease: A nationwide nested case-control study.
<h4>Objectives</h4>Patients with Parkinson's disease (PD) have higher prevalence of depression than the general population; however, the risk factors for depression in PD remain uncertain.<h4>Methods/design</h4>Using the 2000-2010 Taiwan National Health Insurance Researc...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2020-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0236443 |
| _version_ | 1819128676721098752 |
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| author | Yang-Pei Chang Min-Sheng Lee Da-Wei Wu Jui-Hsiu Tsai Pei-Shan Ho Chun-Hung Richard Lin Hung-Yi Chuang |
| author_facet | Yang-Pei Chang Min-Sheng Lee Da-Wei Wu Jui-Hsiu Tsai Pei-Shan Ho Chun-Hung Richard Lin Hung-Yi Chuang |
| author_sort | Yang-Pei Chang |
| collection | DOAJ |
| description | <h4>Objectives</h4>Patients with Parkinson's disease (PD) have higher prevalence of depression than the general population; however, the risk factors for depression in PD remain uncertain.<h4>Methods/design</h4>Using the 2000-2010 Taiwan National Health Insurance Research Database, we selected 1767 patients aged ≧ 40 years with new-onset PD during 2000-2009. Among them, 324 patients with a new incidence of depression were enrolled as cases and 972 patients without depression were randomly selected as controls. The groups were frequency-matched at a ratio of 1:3 by age, sex, and index year. Thus, this nested case-control study compared differences between the cases and the controls. Logistic regression models were used to identify risk factors for depression in PD.<h4>Results</h4>Compared with the controls, the odds ratio (OR) of anxiety disorders in the cases was 1.53 (95% confidence interval [95% CI], 1.16-2.02; P = 0.003), after adjusting for the confounding factors of age, sex, index year, geographic region, urban level, monthly income, and other coexisting medical conditions. The OR for sleep disturbances in the cases was 1.49 (95% CI, 1.14-1.96; P = 0.004) compared to the controls, after adjusting these confounding factors. Hence, the risk factors for depression in PD were nonsignificantly associated with physical comorbidities.<h4>Conclusions</h4>In the present study, depression in PD was significantly associated with anxiety disorders and sleep disturbances. Integrated care for early identification and treatment of neuropsychiatric comorbidities is crucial in patients with new-onset PD so as to prevent further PD degeneration. |
| first_indexed | 2024-12-22T08:31:37Z |
| format | Article |
| id | doaj.art-073876cdd483423c819899ab39e84b27 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T08:31:37Z |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-073876cdd483423c819899ab39e84b272022-12-21T18:32:29ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-01157e023644310.1371/journal.pone.0236443Risk factors for depression in patients with Parkinson's disease: A nationwide nested case-control study.Yang-Pei ChangMin-Sheng LeeDa-Wei WuJui-Hsiu TsaiPei-Shan HoChun-Hung Richard LinHung-Yi Chuang<h4>Objectives</h4>Patients with Parkinson's disease (PD) have higher prevalence of depression than the general population; however, the risk factors for depression in PD remain uncertain.<h4>Methods/design</h4>Using the 2000-2010 Taiwan National Health Insurance Research Database, we selected 1767 patients aged ≧ 40 years with new-onset PD during 2000-2009. Among them, 324 patients with a new incidence of depression were enrolled as cases and 972 patients without depression were randomly selected as controls. The groups were frequency-matched at a ratio of 1:3 by age, sex, and index year. Thus, this nested case-control study compared differences between the cases and the controls. Logistic regression models were used to identify risk factors for depression in PD.<h4>Results</h4>Compared with the controls, the odds ratio (OR) of anxiety disorders in the cases was 1.53 (95% confidence interval [95% CI], 1.16-2.02; P = 0.003), after adjusting for the confounding factors of age, sex, index year, geographic region, urban level, monthly income, and other coexisting medical conditions. The OR for sleep disturbances in the cases was 1.49 (95% CI, 1.14-1.96; P = 0.004) compared to the controls, after adjusting these confounding factors. Hence, the risk factors for depression in PD were nonsignificantly associated with physical comorbidities.<h4>Conclusions</h4>In the present study, depression in PD was significantly associated with anxiety disorders and sleep disturbances. Integrated care for early identification and treatment of neuropsychiatric comorbidities is crucial in patients with new-onset PD so as to prevent further PD degeneration.https://doi.org/10.1371/journal.pone.0236443 |
| spellingShingle | Yang-Pei Chang Min-Sheng Lee Da-Wei Wu Jui-Hsiu Tsai Pei-Shan Ho Chun-Hung Richard Lin Hung-Yi Chuang Risk factors for depression in patients with Parkinson's disease: A nationwide nested case-control study. PLoS ONE |
| title | Risk factors for depression in patients with Parkinson's disease: A nationwide nested case-control study. |
| title_full | Risk factors for depression in patients with Parkinson's disease: A nationwide nested case-control study. |
| title_fullStr | Risk factors for depression in patients with Parkinson's disease: A nationwide nested case-control study. |
| title_full_unstemmed | Risk factors for depression in patients with Parkinson's disease: A nationwide nested case-control study. |
| title_short | Risk factors for depression in patients with Parkinson's disease: A nationwide nested case-control study. |
| title_sort | risk factors for depression in patients with parkinson s disease a nationwide nested case control study |
| url | https://doi.org/10.1371/journal.pone.0236443 |
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