Pathogenesis of Cerebral Malaria: New Trends and Insights for Developing Adjunctive Therapies
No specific or adjunctive therapies exist to treat cerebral malaria (CM) as of date. CM is a neuropathological manifestation of the malaria infection in humans, caused by the hemoparasitic pathogen <i>Plasmodium falciparum</i>. Driven through a multitude of virulence factors, varied immu...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/12/4/522 |
| _version_ | 1797603924546420736 |
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| author | Praveen Kishore Sahu Sanjib Mohanty |
| author_facet | Praveen Kishore Sahu Sanjib Mohanty |
| author_sort | Praveen Kishore Sahu |
| collection | DOAJ |
| description | No specific or adjunctive therapies exist to treat cerebral malaria (CM) as of date. CM is a neuropathological manifestation of the malaria infection in humans, caused by the hemoparasitic pathogen <i>Plasmodium falciparum</i>. Driven through a multitude of virulence factors, varied immune responses, variations in brain swelling with regard to the age of patients, parasite biomass, and parasite-typing, the essential pathogenetic mechanisms underlying clinical CM have remained elusive. However, a recent series of studies based on molecular, immunologic, and advanced neuroradiologic and machine-learning approaches have unraveled new trends and insights to better understand and focus on the key determinants of CM in humans. This could possibly be the beginning of the design of new and effective adjunctive therapies that may not be common or applicable to the entire malarious world, but that could, rather, be specific to the variations in the determinants of CM. |
| first_indexed | 2024-03-11T04:38:57Z |
| format | Article |
| id | doaj.art-0739caef22114f84a95e1a2680732246 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-11T04:38:57Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-0739caef22114f84a95e1a26807322462023-11-17T20:47:55ZengMDPI AGPathogens2076-08172023-03-0112452210.3390/pathogens12040522Pathogenesis of Cerebral Malaria: New Trends and Insights for Developing Adjunctive TherapiesPraveen Kishore Sahu0Sanjib Mohanty1Department of Molecular Biology & Infectious Diseases, Community Welfare Society Hospital, Rourkela 769042, Odisha, IndiaDepartment of Molecular Biology & Infectious Diseases, Community Welfare Society Hospital, Rourkela 769042, Odisha, IndiaNo specific or adjunctive therapies exist to treat cerebral malaria (CM) as of date. CM is a neuropathological manifestation of the malaria infection in humans, caused by the hemoparasitic pathogen <i>Plasmodium falciparum</i>. Driven through a multitude of virulence factors, varied immune responses, variations in brain swelling with regard to the age of patients, parasite biomass, and parasite-typing, the essential pathogenetic mechanisms underlying clinical CM have remained elusive. However, a recent series of studies based on molecular, immunologic, and advanced neuroradiologic and machine-learning approaches have unraveled new trends and insights to better understand and focus on the key determinants of CM in humans. This could possibly be the beginning of the design of new and effective adjunctive therapies that may not be common or applicable to the entire malarious world, but that could, rather, be specific to the variations in the determinants of CM.https://www.mdpi.com/2076-0817/12/4/522cerebral malariapathogenesis<i>Plasmodium falciparum</i>brain swellingadjunctive therapies |
| spellingShingle | Praveen Kishore Sahu Sanjib Mohanty Pathogenesis of Cerebral Malaria: New Trends and Insights for Developing Adjunctive Therapies Pathogens cerebral malaria pathogenesis <i>Plasmodium falciparum</i> brain swelling adjunctive therapies |
| title | Pathogenesis of Cerebral Malaria: New Trends and Insights for Developing Adjunctive Therapies |
| title_full | Pathogenesis of Cerebral Malaria: New Trends and Insights for Developing Adjunctive Therapies |
| title_fullStr | Pathogenesis of Cerebral Malaria: New Trends and Insights for Developing Adjunctive Therapies |
| title_full_unstemmed | Pathogenesis of Cerebral Malaria: New Trends and Insights for Developing Adjunctive Therapies |
| title_short | Pathogenesis of Cerebral Malaria: New Trends and Insights for Developing Adjunctive Therapies |
| title_sort | pathogenesis of cerebral malaria new trends and insights for developing adjunctive therapies |
| topic | cerebral malaria pathogenesis <i>Plasmodium falciparum</i> brain swelling adjunctive therapies |
| url | https://www.mdpi.com/2076-0817/12/4/522 |
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