Over time relationship between platelet reactivity, myocardial injury and mortality in patients with SARS-CoV-2-associated respiratory failure
The aim of this study (NCT04343053) is to investigate the relationship between platelet activation, myocardial injury, and mortality in patients affected by Coronavirus disease 2019 (COVID-19). Fifty-four patients with respiratory failure due to severe acute respiratory syndrome coronavirus 2 (SARS-...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-05-01
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| Series: | Platelets |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09537104.2020.1852543 |
| _version_ | 1827816800555892736 |
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| author | Gianluca Campo Marco Contoli Alberto Fogagnolo Francesco Vieceli Dalla Sega Ottavio Zucchetti Luca Ronzoni Marco Verri Francesca Fortini Rita Pavasini Luca Morandi Simone Biscaglia Luca Di Ienno Emanuele D’Aniello Marco Manfrini Roberto Zoppellari Paola Rizzo Roberto Ferrari Carlo Alberto Volta Alberto Papi Savino Spadaro |
| author_facet | Gianluca Campo Marco Contoli Alberto Fogagnolo Francesco Vieceli Dalla Sega Ottavio Zucchetti Luca Ronzoni Marco Verri Francesca Fortini Rita Pavasini Luca Morandi Simone Biscaglia Luca Di Ienno Emanuele D’Aniello Marco Manfrini Roberto Zoppellari Paola Rizzo Roberto Ferrari Carlo Alberto Volta Alberto Papi Savino Spadaro |
| author_sort | Gianluca Campo |
| collection | DOAJ |
| description | The aim of this study (NCT04343053) is to investigate the relationship between platelet activation, myocardial injury, and mortality in patients affected by Coronavirus disease 2019 (COVID-19). Fifty-four patients with respiratory failure due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection were enrolled as cases. Eleven patients with the same clinical presentation, but negative for SARS-CoV-2 infection, were included as controls. Blood samples were collected at three different time points (inclusion [T1], after 7 ± 2 days [T2] and 14 ± 2 days [T3]). Platelet aggregation by light transmittance aggregometry and the circulating levels of soluble CD40 ligand (sCD40L) and P-selectin were measured. Platelet biomarkers did not differ between cases and controls, except for sCD40L which was higher in COVID-19 patients (p = .003). In COVID-19 patients, P-selectin and sCD40L levels decreased from T1 to T3 and were higher in cases requiring admission to intensive care unit (p = .004 and p = .008, respectively). Patients with myocardial injury (37%), as well as those who died (30%), had higher values of all biomarkers of platelet activation (p < .05 for all). Myocardial injury was an independent predictor of mortality. In COVID-19 patients admitted to hospital for respiratory failure, heightened platelet activation is associated with severity of illness, myocardial injury, and mortality. ClinicalTrials.gov number: NCT04343053. |
| first_indexed | 2024-03-12T00:25:48Z |
| format | Article |
| id | doaj.art-073a0285a7b2410da409bbac8d6c5eec |
| institution | Directory Open Access Journal |
| issn | 0953-7104 1369-1635 |
| language | English |
| last_indexed | 2024-03-12T00:25:48Z |
| publishDate | 2021-05-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Platelets |
| spelling | doaj.art-073a0285a7b2410da409bbac8d6c5eec2023-09-15T10:38:09ZengTaylor & Francis GroupPlatelets0953-71041369-16352021-05-0132456056710.1080/09537104.2020.18525431852543Over time relationship between platelet reactivity, myocardial injury and mortality in patients with SARS-CoV-2-associated respiratory failureGianluca Campo0Marco Contoli1Alberto Fogagnolo2Francesco Vieceli Dalla Sega3Ottavio Zucchetti4Luca Ronzoni5Marco Verri6Francesca Fortini7Rita Pavasini8Luca Morandi9Simone Biscaglia10Luca Di Ienno11Emanuele D’Aniello12Marco Manfrini13Roberto Zoppellari14Paola Rizzo15Roberto Ferrari16Carlo Alberto Volta17Alberto Papi18Savino Spadaro19Azienda Ospedaliero-Universitaria Di FerraraUniversity of FerraraUniversity of FerraraGVM Care & ResearchAzienda Ospedaliero-Universitaria Di FerraraUniversity of FerraraUniversity of FerraraGVM Care & ResearchAzienda Ospedaliero-Universitaria Di FerraraUniversity of FerraraAzienda Ospedaliero-Universitaria Di FerraraAzienda Ospedaliero-Universitaria Di FerraraAzienda Ospedaliero-Universitaria Di FerraraGVM Care & ResearchUniversity of FerraraGVM Care & ResearchAzienda Ospedaliero-Universitaria Di FerraraUniversity of FerraraUniversity of FerraraUniversity of FerraraThe aim of this study (NCT04343053) is to investigate the relationship between platelet activation, myocardial injury, and mortality in patients affected by Coronavirus disease 2019 (COVID-19). Fifty-four patients with respiratory failure due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection were enrolled as cases. Eleven patients with the same clinical presentation, but negative for SARS-CoV-2 infection, were included as controls. Blood samples were collected at three different time points (inclusion [T1], after 7 ± 2 days [T2] and 14 ± 2 days [T3]). Platelet aggregation by light transmittance aggregometry and the circulating levels of soluble CD40 ligand (sCD40L) and P-selectin were measured. Platelet biomarkers did not differ between cases and controls, except for sCD40L which was higher in COVID-19 patients (p = .003). In COVID-19 patients, P-selectin and sCD40L levels decreased from T1 to T3 and were higher in cases requiring admission to intensive care unit (p = .004 and p = .008, respectively). Patients with myocardial injury (37%), as well as those who died (30%), had higher values of all biomarkers of platelet activation (p < .05 for all). Myocardial injury was an independent predictor of mortality. In COVID-19 patients admitted to hospital for respiratory failure, heightened platelet activation is associated with severity of illness, myocardial injury, and mortality. ClinicalTrials.gov number: NCT04343053.http://dx.doi.org/10.1080/09537104.2020.1852543covid-19myocardial injuryplatelet aggregationp-selectinsoluble cd40 ligand |
| spellingShingle | Gianluca Campo Marco Contoli Alberto Fogagnolo Francesco Vieceli Dalla Sega Ottavio Zucchetti Luca Ronzoni Marco Verri Francesca Fortini Rita Pavasini Luca Morandi Simone Biscaglia Luca Di Ienno Emanuele D’Aniello Marco Manfrini Roberto Zoppellari Paola Rizzo Roberto Ferrari Carlo Alberto Volta Alberto Papi Savino Spadaro Over time relationship between platelet reactivity, myocardial injury and mortality in patients with SARS-CoV-2-associated respiratory failure Platelets covid-19 myocardial injury platelet aggregation p-selectin soluble cd40 ligand |
| title | Over time relationship between platelet reactivity, myocardial injury and mortality in patients with SARS-CoV-2-associated respiratory failure |
| title_full | Over time relationship between platelet reactivity, myocardial injury and mortality in patients with SARS-CoV-2-associated respiratory failure |
| title_fullStr | Over time relationship between platelet reactivity, myocardial injury and mortality in patients with SARS-CoV-2-associated respiratory failure |
| title_full_unstemmed | Over time relationship between platelet reactivity, myocardial injury and mortality in patients with SARS-CoV-2-associated respiratory failure |
| title_short | Over time relationship between platelet reactivity, myocardial injury and mortality in patients with SARS-CoV-2-associated respiratory failure |
| title_sort | over time relationship between platelet reactivity myocardial injury and mortality in patients with sars cov 2 associated respiratory failure |
| topic | covid-19 myocardial injury platelet aggregation p-selectin soluble cd40 ligand |
| url | http://dx.doi.org/10.1080/09537104.2020.1852543 |
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