Model for Quantitative Evaluation of Enzyme Replacement Treatment
Gaucher disease is the most frequent lysosomal disorder. Its enzyme replacement treatment was the new progress of modern biotechnology, successfully used in the last years. The evaluation of optimal dose of each patient is important due to health and economical reasons. The enzyme replacement is the...
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| Format: | Article |
| Language: | English |
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Academic Publishing House
2009-12-01
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| Series: | Bioautomation |
| Subjects: | |
| Online Access: | http://www.clbme.bas.bg/bioautomation/2009/vol_13.4/files/13.4_4.09.pdf |
| _version_ | 1828316135372619776 |
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| author | Radeva B. |
| author_facet | Radeva B. |
| author_sort | Radeva B. |
| collection | DOAJ |
| description | Gaucher disease is the most frequent lysosomal disorder. Its enzyme replacement treatment was the new progress of modern biotechnology, successfully used in the last years. The evaluation of optimal dose of each patient is important due to health and economical reasons. The enzyme replacement is the most expensive treatment. It must be held continuously and without interruption. Since 2001, the enzyme replacement therapy with Cerezyme*Genzyme was formally introduced in Bulgaria, but after some time it was interrupted for 1-2 months. The dose of the patients was not optimal. The aim of our work is to find a mathematical model for quantitative evaluation of ERT of Gaucher disease. The model applies a kind of software called "Statistika 6" via the input of the individual data of 5-year-old children having the Gaucher disease treated with Cerezyme. The output results of the model gave possibilities for quantitative evaluation of the individual trends in the development of the disease of each child and its correlation. On the basis of this results, we might recommend suitable changes in ERT. |
| first_indexed | 2024-04-13T17:10:32Z |
| format | Article |
| id | doaj.art-073d026028de4d68ae22a46b07bd4c75 |
| institution | Directory Open Access Journal |
| issn | 1313-261X 1312-451X |
| language | English |
| last_indexed | 2024-04-13T17:10:32Z |
| publishDate | 2009-12-01 |
| publisher | Academic Publishing House |
| record_format | Article |
| series | Bioautomation |
| spelling | doaj.art-073d026028de4d68ae22a46b07bd4c752022-12-22T02:38:18ZengAcademic Publishing HouseBioautomation1313-261X1312-451X2009-12-01134249256Model for Quantitative Evaluation of Enzyme Replacement TreatmentRadeva B.Gaucher disease is the most frequent lysosomal disorder. Its enzyme replacement treatment was the new progress of modern biotechnology, successfully used in the last years. The evaluation of optimal dose of each patient is important due to health and economical reasons. The enzyme replacement is the most expensive treatment. It must be held continuously and without interruption. Since 2001, the enzyme replacement therapy with Cerezyme*Genzyme was formally introduced in Bulgaria, but after some time it was interrupted for 1-2 months. The dose of the patients was not optimal. The aim of our work is to find a mathematical model for quantitative evaluation of ERT of Gaucher disease. The model applies a kind of software called "Statistika 6" via the input of the individual data of 5-year-old children having the Gaucher disease treated with Cerezyme. The output results of the model gave possibilities for quantitative evaluation of the individual trends in the development of the disease of each child and its correlation. On the basis of this results, we might recommend suitable changes in ERT.http://www.clbme.bas.bg/bioautomation/2009/vol_13.4/files/13.4_4.09.pdfMathematical modelEnzyme replacement therapyGaucher disease |
| spellingShingle | Radeva B. Model for Quantitative Evaluation of Enzyme Replacement Treatment Bioautomation Mathematical model Enzyme replacement therapy Gaucher disease |
| title | Model for Quantitative Evaluation of Enzyme Replacement Treatment |
| title_full | Model for Quantitative Evaluation of Enzyme Replacement Treatment |
| title_fullStr | Model for Quantitative Evaluation of Enzyme Replacement Treatment |
| title_full_unstemmed | Model for Quantitative Evaluation of Enzyme Replacement Treatment |
| title_short | Model for Quantitative Evaluation of Enzyme Replacement Treatment |
| title_sort | model for quantitative evaluation of enzyme replacement treatment |
| topic | Mathematical model Enzyme replacement therapy Gaucher disease |
| url | http://www.clbme.bas.bg/bioautomation/2009/vol_13.4/files/13.4_4.09.pdf |
| work_keys_str_mv | AT radevab modelforquantitativeevaluationofenzymereplacementtreatment |