Enhanced Global-Brain Functional Connectivity in the Left Superior Frontal Gyrus as a Possible Endophenotype for Schizophrenia
The notion of dysconnectivity in schizophrenia has been put forward for many years and results in substantial attempts to explore altered functional connectivity (FC) within different networks with inconsistent results. Clinical, demographical, and methodological heterogeneity may contribute to the...
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Frontiers Media S.A.
2019-02-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnins.2019.00145/full |
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| author | Yudan Ding Yangpan Ou Qinji Su Pan Pan Xiaoxiao Shan Jindong Chen Feng Liu Zhikun Zhang Jingping Zhao Wenbin Guo |
| author_facet | Yudan Ding Yangpan Ou Qinji Su Pan Pan Xiaoxiao Shan Jindong Chen Feng Liu Zhikun Zhang Jingping Zhao Wenbin Guo |
| author_sort | Yudan Ding |
| collection | DOAJ |
| description | The notion of dysconnectivity in schizophrenia has been put forward for many years and results in substantial attempts to explore altered functional connectivity (FC) within different networks with inconsistent results. Clinical, demographical, and methodological heterogeneity may contribute to the inconsistency. Forty-four patients with first-episode, drug-naive schizophrenia, 42 unaffected siblings of schizophrenia patients and 44 healthy controls took part in this study. Global-brain FC (GFC) was employed to analyze the imaging data. Compared with healthy controls, patients with schizophrenia and unaffected siblings shared enhanced GFC in the left superior frontal gyrus (SFG). In addition, patients had increased GFC mainly in the thalamo-cortical network, including the bilateral thalamus, bilateral posterior cingulate cortex (PCC)/precuneus, left superior medial prefrontal cortex (MPFC), right angular gyrus, and right SFG/middle frontal gyrus and decreased GFC in the left ITG/cerebellum Crus I. No other altered GFC values were observed in the siblings group relative to the control group. Further ROC analysis showed that increased GFC in the left SFG could separate the patients or the siblings from the controls with acceptable sensitivities. Our findings suggest that increased GFC in the left SFG may serve as a potential endophenotype for schizophrenia. |
| first_indexed | 2024-12-19T04:04:11Z |
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| id | doaj.art-073d5b7101b3443fbf485b914021f2d7 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-19T04:04:11Z |
| publishDate | 2019-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neuroscience |
| spelling | doaj.art-073d5b7101b3443fbf485b914021f2d72022-12-21T20:36:34ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2019-02-011310.3389/fnins.2019.00145432999Enhanced Global-Brain Functional Connectivity in the Left Superior Frontal Gyrus as a Possible Endophenotype for SchizophreniaYudan Ding0Yangpan Ou1Qinji Su2Pan Pan3Xiaoxiao Shan4Jindong Chen5Feng Liu6Zhikun Zhang7Jingping Zhao8Wenbin Guo9Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, ChinaMental Health Center, The Second Affiliated Hospital of Guangxi Medical University, Nanning, ChinaDepartment of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Radiology, Tianjin Medical University General Hospital, Tianjin, ChinaMental Health Center, The Second Affiliated Hospital of Guangxi Medical University, Nanning, ChinaDepartment of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, ChinaThe notion of dysconnectivity in schizophrenia has been put forward for many years and results in substantial attempts to explore altered functional connectivity (FC) within different networks with inconsistent results. Clinical, demographical, and methodological heterogeneity may contribute to the inconsistency. Forty-four patients with first-episode, drug-naive schizophrenia, 42 unaffected siblings of schizophrenia patients and 44 healthy controls took part in this study. Global-brain FC (GFC) was employed to analyze the imaging data. Compared with healthy controls, patients with schizophrenia and unaffected siblings shared enhanced GFC in the left superior frontal gyrus (SFG). In addition, patients had increased GFC mainly in the thalamo-cortical network, including the bilateral thalamus, bilateral posterior cingulate cortex (PCC)/precuneus, left superior medial prefrontal cortex (MPFC), right angular gyrus, and right SFG/middle frontal gyrus and decreased GFC in the left ITG/cerebellum Crus I. No other altered GFC values were observed in the siblings group relative to the control group. Further ROC analysis showed that increased GFC in the left SFG could separate the patients or the siblings from the controls with acceptable sensitivities. Our findings suggest that increased GFC in the left SFG may serve as a potential endophenotype for schizophrenia.https://www.frontiersin.org/article/10.3389/fnins.2019.00145/fullschizophreniaglobal-brain functional connectivityfunctional magnetic resonance imagingendophenotypenetwork |
| spellingShingle | Yudan Ding Yangpan Ou Qinji Su Pan Pan Xiaoxiao Shan Jindong Chen Feng Liu Zhikun Zhang Jingping Zhao Wenbin Guo Enhanced Global-Brain Functional Connectivity in the Left Superior Frontal Gyrus as a Possible Endophenotype for Schizophrenia Frontiers in Neuroscience schizophrenia global-brain functional connectivity functional magnetic resonance imaging endophenotype network |
| title | Enhanced Global-Brain Functional Connectivity in the Left Superior Frontal Gyrus as a Possible Endophenotype for Schizophrenia |
| title_full | Enhanced Global-Brain Functional Connectivity in the Left Superior Frontal Gyrus as a Possible Endophenotype for Schizophrenia |
| title_fullStr | Enhanced Global-Brain Functional Connectivity in the Left Superior Frontal Gyrus as a Possible Endophenotype for Schizophrenia |
| title_full_unstemmed | Enhanced Global-Brain Functional Connectivity in the Left Superior Frontal Gyrus as a Possible Endophenotype for Schizophrenia |
| title_short | Enhanced Global-Brain Functional Connectivity in the Left Superior Frontal Gyrus as a Possible Endophenotype for Schizophrenia |
| title_sort | enhanced global brain functional connectivity in the left superior frontal gyrus as a possible endophenotype for schizophrenia |
| topic | schizophrenia global-brain functional connectivity functional magnetic resonance imaging endophenotype network |
| url | https://www.frontiersin.org/article/10.3389/fnins.2019.00145/full |
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