Association between cadmium and anti-Mullerian hormone in premenopausal women at particular ages
Abstract Background Anti-Mullerian hormone (AMH) in women is secreted by granulosa cells of antral follicles. AMH appears to be a very stable marker for ovarian function. It may be used to diagnosis cases of premature ovarian failure, polycystic ovary syndrome (PCOS), and ovarian tumors. It has been...
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Format: | Article |
Language: | English |
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Korean Society of Occupational & Environmental Medicine
2018-07-01
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Series: | Annals of Occupational and Environmental Medicine |
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Online Access: | http://link.springer.com/article/10.1186/s40557-018-0255-7 |
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author | Yu min Lee Hye Won Chung Kyungah Jeong Yeon-Ah Sung Hyejin Lee Shinhee Ye Eun-Hee Ha |
author_facet | Yu min Lee Hye Won Chung Kyungah Jeong Yeon-Ah Sung Hyejin Lee Shinhee Ye Eun-Hee Ha |
author_sort | Yu min Lee |
collection | DOAJ |
description | Abstract Background Anti-Mullerian hormone (AMH) in women is secreted by granulosa cells of antral follicles. AMH appears to be a very stable marker for ovarian function. It may be used to diagnosis cases of premature ovarian failure, polycystic ovary syndrome (PCOS), and ovarian tumors. It has been suggested that cadmium exposure can reduce female fecundity. The purpose of this study was to investigate whether environmental exposure to cadmium was associated with alterations in AMH with regards to age. Methods In a cross-sectional study, the data of premenopausal women living in Seoul, ranging from 30 to 45 of age was collected. The study included a total of 283 women who completed serum AMH and whole blood cadmium assessments. Linear regression analyses were used in order to examine the association between cadmium and AMH. Given that age was the strongest confounder in both cadmium and AMH concentrations, we stratified subjects by 5 years old and analyzed their data. Results Geometric mean concentrations of blood cadmium and AMH were 0.97 μg/L and 3.02 ng/ml, respectively. Total association between cadmium and AMH was statistically significant (adjusted coefficient = − 0.34 (0.15), p = 0.02). After stratification, the only age group with a negative association between cadmium and AMH were the women raging between 30 and 35 years (adjusted coefficient = − 0.43 (0.18), p = 0.01). Conclusions The results of this study suggest that environmental exposure to cadmium may alter the AMH level of premenopausal women, depending on their age group. |
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institution | Directory Open Access Journal |
issn | 2052-4374 |
language | English |
last_indexed | 2024-04-12T11:58:43Z |
publishDate | 2018-07-01 |
publisher | Korean Society of Occupational & Environmental Medicine |
record_format | Article |
series | Annals of Occupational and Environmental Medicine |
spelling | doaj.art-073ed19c57a742f295d31f47745d98522022-12-22T03:33:56ZengKorean Society of Occupational & Environmental MedicineAnnals of Occupational and Environmental Medicine2052-43742018-07-013011610.1186/s40557-018-0255-7Association between cadmium and anti-Mullerian hormone in premenopausal women at particular agesYu min Lee0Hye Won Chung1Kyungah Jeong2Yeon-Ah Sung3Hyejin Lee4Shinhee Ye5Eun-Hee Ha6Department of Occupational and Environmental Medicine, Ewha Womans University School of MedicineDepartment of Occupational and Environmental Medicine, Ewha Womans University School of MedicineDepartment of Occupational and Environmental Medicine, Ewha Womans University School of MedicineDepartment of Occupational and Environmental Medicine, Ewha Womans University School of MedicineDepartment of Occupational and Environmental Medicine, Ewha Womans University School of MedicineDepartment of Occupational and Environmental Medicine, Ewha Womans University School of MedicineDepartment of Occupational and Environmental Medicine, Ewha Womans University School of MedicineAbstract Background Anti-Mullerian hormone (AMH) in women is secreted by granulosa cells of antral follicles. AMH appears to be a very stable marker for ovarian function. It may be used to diagnosis cases of premature ovarian failure, polycystic ovary syndrome (PCOS), and ovarian tumors. It has been suggested that cadmium exposure can reduce female fecundity. The purpose of this study was to investigate whether environmental exposure to cadmium was associated with alterations in AMH with regards to age. Methods In a cross-sectional study, the data of premenopausal women living in Seoul, ranging from 30 to 45 of age was collected. The study included a total of 283 women who completed serum AMH and whole blood cadmium assessments. Linear regression analyses were used in order to examine the association between cadmium and AMH. Given that age was the strongest confounder in both cadmium and AMH concentrations, we stratified subjects by 5 years old and analyzed their data. Results Geometric mean concentrations of blood cadmium and AMH were 0.97 μg/L and 3.02 ng/ml, respectively. Total association between cadmium and AMH was statistically significant (adjusted coefficient = − 0.34 (0.15), p = 0.02). After stratification, the only age group with a negative association between cadmium and AMH were the women raging between 30 and 35 years (adjusted coefficient = − 0.43 (0.18), p = 0.01). Conclusions The results of this study suggest that environmental exposure to cadmium may alter the AMH level of premenopausal women, depending on their age group.http://link.springer.com/article/10.1186/s40557-018-0255-7Anti-Mullerian hormoneCadmiumPremenopausal womenAges |
spellingShingle | Yu min Lee Hye Won Chung Kyungah Jeong Yeon-Ah Sung Hyejin Lee Shinhee Ye Eun-Hee Ha Association between cadmium and anti-Mullerian hormone in premenopausal women at particular ages Annals of Occupational and Environmental Medicine Anti-Mullerian hormone Cadmium Premenopausal women Ages |
title | Association between cadmium and anti-Mullerian hormone in premenopausal women at particular ages |
title_full | Association between cadmium and anti-Mullerian hormone in premenopausal women at particular ages |
title_fullStr | Association between cadmium and anti-Mullerian hormone in premenopausal women at particular ages |
title_full_unstemmed | Association between cadmium and anti-Mullerian hormone in premenopausal women at particular ages |
title_short | Association between cadmium and anti-Mullerian hormone in premenopausal women at particular ages |
title_sort | association between cadmium and anti mullerian hormone in premenopausal women at particular ages |
topic | Anti-Mullerian hormone Cadmium Premenopausal women Ages |
url | http://link.springer.com/article/10.1186/s40557-018-0255-7 |
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