Association between cadmium and anti-Mullerian hormone in premenopausal women at particular ages

Abstract Background Anti-Mullerian hormone (AMH) in women is secreted by granulosa cells of antral follicles. AMH appears to be a very stable marker for ovarian function. It may be used to diagnosis cases of premature ovarian failure, polycystic ovary syndrome (PCOS), and ovarian tumors. It has been...

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Main Authors: Yu min Lee, Hye Won Chung, Kyungah Jeong, Yeon-Ah Sung, Hyejin Lee, Shinhee Ye, Eun-Hee Ha
Format: Article
Language:English
Published: Korean Society of Occupational & Environmental Medicine 2018-07-01
Series:Annals of Occupational and Environmental Medicine
Subjects:
Online Access:http://link.springer.com/article/10.1186/s40557-018-0255-7
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author Yu min Lee
Hye Won Chung
Kyungah Jeong
Yeon-Ah Sung
Hyejin Lee
Shinhee Ye
Eun-Hee Ha
author_facet Yu min Lee
Hye Won Chung
Kyungah Jeong
Yeon-Ah Sung
Hyejin Lee
Shinhee Ye
Eun-Hee Ha
author_sort Yu min Lee
collection DOAJ
description Abstract Background Anti-Mullerian hormone (AMH) in women is secreted by granulosa cells of antral follicles. AMH appears to be a very stable marker for ovarian function. It may be used to diagnosis cases of premature ovarian failure, polycystic ovary syndrome (PCOS), and ovarian tumors. It has been suggested that cadmium exposure can reduce female fecundity. The purpose of this study was to investigate whether environmental exposure to cadmium was associated with alterations in AMH with regards to age. Methods In a cross-sectional study, the data of premenopausal women living in Seoul, ranging from 30 to 45 of age was collected. The study included a total of 283 women who completed serum AMH and whole blood cadmium assessments. Linear regression analyses were used in order to examine the association between cadmium and AMH. Given that age was the strongest confounder in both cadmium and AMH concentrations, we stratified subjects by 5 years old and analyzed their data. Results Geometric mean concentrations of blood cadmium and AMH were 0.97 μg/L and 3.02 ng/ml, respectively. Total association between cadmium and AMH was statistically significant (adjusted coefficient = − 0.34 (0.15), p = 0.02). After stratification, the only age group with a negative association between cadmium and AMH were the women raging between 30 and 35 years (adjusted coefficient = − 0.43 (0.18), p = 0.01). Conclusions The results of this study suggest that environmental exposure to cadmium may alter the AMH level of premenopausal women, depending on their age group.
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spelling doaj.art-073ed19c57a742f295d31f47745d98522022-12-22T03:33:56ZengKorean Society of Occupational & Environmental MedicineAnnals of Occupational and Environmental Medicine2052-43742018-07-013011610.1186/s40557-018-0255-7Association between cadmium and anti-Mullerian hormone in premenopausal women at particular agesYu min Lee0Hye Won Chung1Kyungah Jeong2Yeon-Ah Sung3Hyejin Lee4Shinhee Ye5Eun-Hee Ha6Department of Occupational and Environmental Medicine, Ewha Womans University School of MedicineDepartment of Occupational and Environmental Medicine, Ewha Womans University School of MedicineDepartment of Occupational and Environmental Medicine, Ewha Womans University School of MedicineDepartment of Occupational and Environmental Medicine, Ewha Womans University School of MedicineDepartment of Occupational and Environmental Medicine, Ewha Womans University School of MedicineDepartment of Occupational and Environmental Medicine, Ewha Womans University School of MedicineDepartment of Occupational and Environmental Medicine, Ewha Womans University School of MedicineAbstract Background Anti-Mullerian hormone (AMH) in women is secreted by granulosa cells of antral follicles. AMH appears to be a very stable marker for ovarian function. It may be used to diagnosis cases of premature ovarian failure, polycystic ovary syndrome (PCOS), and ovarian tumors. It has been suggested that cadmium exposure can reduce female fecundity. The purpose of this study was to investigate whether environmental exposure to cadmium was associated with alterations in AMH with regards to age. Methods In a cross-sectional study, the data of premenopausal women living in Seoul, ranging from 30 to 45 of age was collected. The study included a total of 283 women who completed serum AMH and whole blood cadmium assessments. Linear regression analyses were used in order to examine the association between cadmium and AMH. Given that age was the strongest confounder in both cadmium and AMH concentrations, we stratified subjects by 5 years old and analyzed their data. Results Geometric mean concentrations of blood cadmium and AMH were 0.97 μg/L and 3.02 ng/ml, respectively. Total association between cadmium and AMH was statistically significant (adjusted coefficient = − 0.34 (0.15), p = 0.02). After stratification, the only age group with a negative association between cadmium and AMH were the women raging between 30 and 35 years (adjusted coefficient = − 0.43 (0.18), p = 0.01). Conclusions The results of this study suggest that environmental exposure to cadmium may alter the AMH level of premenopausal women, depending on their age group.http://link.springer.com/article/10.1186/s40557-018-0255-7Anti-Mullerian hormoneCadmiumPremenopausal womenAges
spellingShingle Yu min Lee
Hye Won Chung
Kyungah Jeong
Yeon-Ah Sung
Hyejin Lee
Shinhee Ye
Eun-Hee Ha
Association between cadmium and anti-Mullerian hormone in premenopausal women at particular ages
Annals of Occupational and Environmental Medicine
Anti-Mullerian hormone
Cadmium
Premenopausal women
Ages
title Association between cadmium and anti-Mullerian hormone in premenopausal women at particular ages
title_full Association between cadmium and anti-Mullerian hormone in premenopausal women at particular ages
title_fullStr Association between cadmium and anti-Mullerian hormone in premenopausal women at particular ages
title_full_unstemmed Association between cadmium and anti-Mullerian hormone in premenopausal women at particular ages
title_short Association between cadmium and anti-Mullerian hormone in premenopausal women at particular ages
title_sort association between cadmium and anti mullerian hormone in premenopausal women at particular ages
topic Anti-Mullerian hormone
Cadmium
Premenopausal women
Ages
url http://link.springer.com/article/10.1186/s40557-018-0255-7
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