Successful Cerebral Hemorrhage Control with Prothrombin Complex Concentrate in a Patient on Edoxaban Therapy: A Case Report
Giuseppe Galbiati Emergency Department, Policlinico San Marco, Zingonia, BG, ItalyCorrespondence: Giuseppe GalbiatiEmergency DepartmentPoliclinico San Marco, Zingonia, BG, ItalyTel +39 035886445Email galbiati.g@libero.itAbstract: Direct oral anticoagulants (DOACs) have demonstrated safety and effica...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2020-01-01
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| Series: | Journal of Blood Medicine |
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| Online Access: | https://www.dovepress.com/successful-cerebral-hemorrhage-control-with-prothrombin-complex-concen-peer-reviewed-article-JBM |
| _version_ | 1819016575164874752 |
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| author | Galbiati G |
| author_facet | Galbiati G |
| author_sort | Galbiati G |
| collection | DOAJ |
| description | Giuseppe Galbiati Emergency Department, Policlinico San Marco, Zingonia, BG, ItalyCorrespondence: Giuseppe GalbiatiEmergency DepartmentPoliclinico San Marco, Zingonia, BG, ItalyTel +39 035886445Email galbiati.g@libero.itAbstract: Direct oral anticoagulants (DOACs) have demonstrated safety and efficacy in stroke prevention in patients with non-valvular atrial fibrillation (NVAF). In terms of safety, there was a significant reduction of intracranial hemorrhages (ICH) in patients treated with DOACs over warfarin. To date, a specific antidote for edoxaban is not yet available. The management of ICH relies on the use of coagulation factors. This article reports a case of a 73-year-old woman with NVAF who had cerebral hematoma in the right intraparenchymal thalamus-capsular area while on therapy with edoxaban 60 mg/day. The computed tomography (CT) brain scan showed hematoma of > 18mm diameter. The patient was timely treated with four-factor prothrombin complex concentrate (4F-PCC) at 50 IU/kg. After 6 hrs patient’s symptoms alleviated and she was successfully recovered within 6 days. A repeated CT scan of the brain in 3 weeks showed improvement. The patient’s treatment with edoxaban 30 mg/day restarted after 8 weeks.Keywords: non-valvular atrial fibrillation, edoxaban, prothrombin complex concentrate, cerebral hemorrhage |
| first_indexed | 2024-12-21T02:49:48Z |
| format | Article |
| id | doaj.art-0741240c8854424ab457494a63537265 |
| institution | Directory Open Access Journal |
| issn | 1179-2736 |
| language | English |
| last_indexed | 2024-12-21T02:49:48Z |
| publishDate | 2020-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Blood Medicine |
| spelling | doaj.art-0741240c8854424ab457494a635372652022-12-21T19:18:28ZengDove Medical PressJournal of Blood Medicine1179-27362020-01-01Volume 11353851461Successful Cerebral Hemorrhage Control with Prothrombin Complex Concentrate in a Patient on Edoxaban Therapy: A Case ReportGalbiati GGiuseppe Galbiati Emergency Department, Policlinico San Marco, Zingonia, BG, ItalyCorrespondence: Giuseppe GalbiatiEmergency DepartmentPoliclinico San Marco, Zingonia, BG, ItalyTel +39 035886445Email galbiati.g@libero.itAbstract: Direct oral anticoagulants (DOACs) have demonstrated safety and efficacy in stroke prevention in patients with non-valvular atrial fibrillation (NVAF). In terms of safety, there was a significant reduction of intracranial hemorrhages (ICH) in patients treated with DOACs over warfarin. To date, a specific antidote for edoxaban is not yet available. The management of ICH relies on the use of coagulation factors. This article reports a case of a 73-year-old woman with NVAF who had cerebral hematoma in the right intraparenchymal thalamus-capsular area while on therapy with edoxaban 60 mg/day. The computed tomography (CT) brain scan showed hematoma of > 18mm diameter. The patient was timely treated with four-factor prothrombin complex concentrate (4F-PCC) at 50 IU/kg. After 6 hrs patient’s symptoms alleviated and she was successfully recovered within 6 days. A repeated CT scan of the brain in 3 weeks showed improvement. The patient’s treatment with edoxaban 30 mg/day restarted after 8 weeks.Keywords: non-valvular atrial fibrillation, edoxaban, prothrombin complex concentrate, cerebral hemorrhagehttps://www.dovepress.com/successful-cerebral-hemorrhage-control-with-prothrombin-complex-concen-peer-reviewed-article-JBMnon-valvular atrial fibrillationedoxabanprothrombin complex concentratecerebral hemorrhage |
| spellingShingle | Galbiati G Successful Cerebral Hemorrhage Control with Prothrombin Complex Concentrate in a Patient on Edoxaban Therapy: A Case Report Journal of Blood Medicine non-valvular atrial fibrillation edoxaban prothrombin complex concentrate cerebral hemorrhage |
| title | Successful Cerebral Hemorrhage Control with Prothrombin Complex Concentrate in a Patient on Edoxaban Therapy: A Case Report |
| title_full | Successful Cerebral Hemorrhage Control with Prothrombin Complex Concentrate in a Patient on Edoxaban Therapy: A Case Report |
| title_fullStr | Successful Cerebral Hemorrhage Control with Prothrombin Complex Concentrate in a Patient on Edoxaban Therapy: A Case Report |
| title_full_unstemmed | Successful Cerebral Hemorrhage Control with Prothrombin Complex Concentrate in a Patient on Edoxaban Therapy: A Case Report |
| title_short | Successful Cerebral Hemorrhage Control with Prothrombin Complex Concentrate in a Patient on Edoxaban Therapy: A Case Report |
| title_sort | successful cerebral hemorrhage control with prothrombin complex concentrate in a patient on edoxaban therapy a case report |
| topic | non-valvular atrial fibrillation edoxaban prothrombin complex concentrate cerebral hemorrhage |
| url | https://www.dovepress.com/successful-cerebral-hemorrhage-control-with-prothrombin-complex-concen-peer-reviewed-article-JBM |
| work_keys_str_mv | AT galbiatig successfulcerebralhemorrhagecontrolwithprothrombincomplexconcentrateinapatientonedoxabantherapyacasereport |