Estrogenic receptors a and p gene polymorphisms in postmenopausal osteoporosis
Objective. To assess frequency distribution of estrogenic receptor (ER)a and ERfl gene polymorphisms and their influence on bone mineral density (BMD) in groups of postmenopausal women with and without osteoporosis (OP). Material and methods. 200 residents of Moscow and Moscow region were divided in...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
IMA PRESS LLC
2008-06-01
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| Series: | Научно-практическая ревматология |
| Subjects: | |
| Online Access: | https://rsp.mediar-press.net/rsp/article/view/791 |
| _version_ | 1826556177344888832 |
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| author | K A Maslova M Y Krylov N V Toroptsova O A Nikitinskaya T A Korotkova V A Myakotkin L L Benevolenskaya |
| author_facet | K A Maslova M Y Krylov N V Toroptsova O A Nikitinskaya T A Korotkova V A Myakotkin L L Benevolenskaya |
| author_sort | K A Maslova |
| collection | DOAJ |
| description | Objective. To assess frequency distribution of estrogenic receptor (ER)a and ERfl gene polymorphisms and their influence on bone mineral density (BMD) in groups of postmenopausal women with and without osteoporosis (OP). Material and methods. 200 residents of Moscow and Moscow region were divided into two groups considering BMD values according to WHO criteria; OP group and healthy control group Results. Differences of genotype and their combinations frequency distribution between OP and control groups show presence OP risk and protector genotypes. ER gene important role in pathogenesis of postmenopausal osteoporosis and possibility to use these genetic markers for assessment of risk of OP development in Russian population was confirmed. |
| first_indexed | 2024-04-09T22:26:52Z |
| format | Article |
| id | doaj.art-07432e1c6da4495fa0e48844bdf67f34 |
| institution | Directory Open Access Journal |
| issn | 1995-4484 1995-4492 |
| language | Russian |
| last_indexed | 2025-03-14T08:08:33Z |
| publishDate | 2008-06-01 |
| publisher | IMA PRESS LLC |
| record_format | Article |
| series | Научно-практическая ревматология |
| spelling | doaj.art-07432e1c6da4495fa0e48844bdf67f342025-03-02T13:23:32ZrusIMA PRESS LLCНаучно-практическая ревматология1995-44841995-44922008-06-01463162210.14412/1995-4484-2008-654731Estrogenic receptors a and p gene polymorphisms in postmenopausal osteoporosisK A MaslovaM Y KrylovN V ToroptsovaO A NikitinskayaT A KorotkovaV A MyakotkinL L BenevolenskayaObjective. To assess frequency distribution of estrogenic receptor (ER)a and ERfl gene polymorphisms and their influence on bone mineral density (BMD) in groups of postmenopausal women with and without osteoporosis (OP). Material and methods. 200 residents of Moscow and Moscow region were divided into two groups considering BMD values according to WHO criteria; OP group and healthy control group Results. Differences of genotype and their combinations frequency distribution between OP and control groups show presence OP risk and protector genotypes. ER gene important role in pathogenesis of postmenopausal osteoporosis and possibility to use these genetic markers for assessment of risk of OP development in Russian population was confirmed.https://rsp.mediar-press.net/rsp/article/view/791postmenopausal osteoporosisestrogen receptor genesrisk and protection genotypes |
| spellingShingle | K A Maslova M Y Krylov N V Toroptsova O A Nikitinskaya T A Korotkova V A Myakotkin L L Benevolenskaya Estrogenic receptors a and p gene polymorphisms in postmenopausal osteoporosis Научно-практическая ревматология postmenopausal osteoporosis estrogen receptor genes risk and protection genotypes |
| title | Estrogenic receptors a and p gene polymorphisms in postmenopausal osteoporosis |
| title_full | Estrogenic receptors a and p gene polymorphisms in postmenopausal osteoporosis |
| title_fullStr | Estrogenic receptors a and p gene polymorphisms in postmenopausal osteoporosis |
| title_full_unstemmed | Estrogenic receptors a and p gene polymorphisms in postmenopausal osteoporosis |
| title_short | Estrogenic receptors a and p gene polymorphisms in postmenopausal osteoporosis |
| title_sort | estrogenic receptors a and p gene polymorphisms in postmenopausal osteoporosis |
| topic | postmenopausal osteoporosis estrogen receptor genes risk and protection genotypes |
| url | https://rsp.mediar-press.net/rsp/article/view/791 |
| work_keys_str_mv | AT kamaslova estrogenicreceptorsaandpgenepolymorphismsinpostmenopausalosteoporosis AT mykrylov estrogenicreceptorsaandpgenepolymorphismsinpostmenopausalosteoporosis AT nvtoroptsova estrogenicreceptorsaandpgenepolymorphismsinpostmenopausalosteoporosis AT oanikitinskaya estrogenicreceptorsaandpgenepolymorphismsinpostmenopausalosteoporosis AT takorotkova estrogenicreceptorsaandpgenepolymorphismsinpostmenopausalosteoporosis AT vamyakotkin estrogenicreceptorsaandpgenepolymorphismsinpostmenopausalosteoporosis AT llbenevolenskaya estrogenicreceptorsaandpgenepolymorphismsinpostmenopausalosteoporosis |