Multi-modality human phenotyping to examine subjective and objective health afflictions in former professional American-style football players: The In-Person Assessment (IPA) protocol.
<h4>Background</h4>Participation in American-style football (ASF), one of the most popular sports worldwide, has been associated with adverse health outcomes. However, prior clinical studies of former ASF players have been limited by reliance on subjective self-reported data, inadequate...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0265737 |
| _version_ | 1811338687566315520 |
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| author | Bryan Cortez Chelsea Valdivia Dylan Keating Dean Marengi Trevor Bates Cheyenne Brown Inana Dairi Michael Doyle Robyn Keske Ann Connor Rachel Grashow Adam Tenforde Meagan M Wasfy Marc G Weisskopf Frank Speizer Ross Zafonte Aaron Baggish |
| author_facet | Bryan Cortez Chelsea Valdivia Dylan Keating Dean Marengi Trevor Bates Cheyenne Brown Inana Dairi Michael Doyle Robyn Keske Ann Connor Rachel Grashow Adam Tenforde Meagan M Wasfy Marc G Weisskopf Frank Speizer Ross Zafonte Aaron Baggish |
| author_sort | Bryan Cortez |
| collection | DOAJ |
| description | <h4>Background</h4>Participation in American-style football (ASF), one of the most popular sports worldwide, has been associated with adverse health outcomes. However, prior clinical studies of former ASF players have been limited by reliance on subjective self-reported data, inadequate sample size, or focus on a single disease process in isolation.<h4>Objective</h4>To determine the burden of objective multi-system pathology and its relationship with subjective health complaints among former professional ASF players.<h4>Methods</h4>The In-Person Assessment is a case-control, multi-day, deep human phenotyping protocol designed to characterize and quantify pathology among former professional ASF players. Participants, recruited from an on-going large-scale longitudinal cohort study, will include 120 men who report either no health conditions, a single health condition, or multiple health conditions across the key domains of cardiometabolic disease, disordered sleep, chronic pain, and cognitive impairment. Data will be collected from validated questionnaires, structured interviews, physical examinations, multi-modality imaging, and functional assessments over a 3-day study period. A pilot study was conducted to assess feasibility and to obtain participant feedback which was used to shape the final protocol.<h4>Results</h4>This study provides a comprehensive assessment of objective multi-system pathology and its relationship with subjective health complaints among former professional ASF players.<h4>Conclusion</h4>The study will determine whether subjective health complaints among former professional ASF players are explained by objective explanatory pathology and will provide novel opportunities to examine the interrelatedness of co-morbidities. It is anticipated that this protocol will be applicable to other clinical and occupational populations. |
| first_indexed | 2024-04-13T18:14:49Z |
| format | Article |
| id | doaj.art-074371a79d3c4676a2dbc8ce833bf7c4 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T18:14:49Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-074371a79d3c4676a2dbc8ce833bf7c42022-12-22T02:35:43ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01173e026573710.1371/journal.pone.0265737Multi-modality human phenotyping to examine subjective and objective health afflictions in former professional American-style football players: The In-Person Assessment (IPA) protocol.Bryan CortezChelsea ValdiviaDylan KeatingDean MarengiTrevor BatesCheyenne BrownInana DairiMichael DoyleRobyn KeskeAnn ConnorRachel GrashowAdam TenfordeMeagan M WasfyMarc G WeisskopfFrank SpeizerRoss ZafonteAaron Baggish<h4>Background</h4>Participation in American-style football (ASF), one of the most popular sports worldwide, has been associated with adverse health outcomes. However, prior clinical studies of former ASF players have been limited by reliance on subjective self-reported data, inadequate sample size, or focus on a single disease process in isolation.<h4>Objective</h4>To determine the burden of objective multi-system pathology and its relationship with subjective health complaints among former professional ASF players.<h4>Methods</h4>The In-Person Assessment is a case-control, multi-day, deep human phenotyping protocol designed to characterize and quantify pathology among former professional ASF players. Participants, recruited from an on-going large-scale longitudinal cohort study, will include 120 men who report either no health conditions, a single health condition, or multiple health conditions across the key domains of cardiometabolic disease, disordered sleep, chronic pain, and cognitive impairment. Data will be collected from validated questionnaires, structured interviews, physical examinations, multi-modality imaging, and functional assessments over a 3-day study period. A pilot study was conducted to assess feasibility and to obtain participant feedback which was used to shape the final protocol.<h4>Results</h4>This study provides a comprehensive assessment of objective multi-system pathology and its relationship with subjective health complaints among former professional ASF players.<h4>Conclusion</h4>The study will determine whether subjective health complaints among former professional ASF players are explained by objective explanatory pathology and will provide novel opportunities to examine the interrelatedness of co-morbidities. It is anticipated that this protocol will be applicable to other clinical and occupational populations.https://doi.org/10.1371/journal.pone.0265737 |
| spellingShingle | Bryan Cortez Chelsea Valdivia Dylan Keating Dean Marengi Trevor Bates Cheyenne Brown Inana Dairi Michael Doyle Robyn Keske Ann Connor Rachel Grashow Adam Tenforde Meagan M Wasfy Marc G Weisskopf Frank Speizer Ross Zafonte Aaron Baggish Multi-modality human phenotyping to examine subjective and objective health afflictions in former professional American-style football players: The In-Person Assessment (IPA) protocol. PLoS ONE |
| title | Multi-modality human phenotyping to examine subjective and objective health afflictions in former professional American-style football players: The In-Person Assessment (IPA) protocol. |
| title_full | Multi-modality human phenotyping to examine subjective and objective health afflictions in former professional American-style football players: The In-Person Assessment (IPA) protocol. |
| title_fullStr | Multi-modality human phenotyping to examine subjective and objective health afflictions in former professional American-style football players: The In-Person Assessment (IPA) protocol. |
| title_full_unstemmed | Multi-modality human phenotyping to examine subjective and objective health afflictions in former professional American-style football players: The In-Person Assessment (IPA) protocol. |
| title_short | Multi-modality human phenotyping to examine subjective and objective health afflictions in former professional American-style football players: The In-Person Assessment (IPA) protocol. |
| title_sort | multi modality human phenotyping to examine subjective and objective health afflictions in former professional american style football players the in person assessment ipa protocol |
| url | https://doi.org/10.1371/journal.pone.0265737 |
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