Squamous cell carcinoma of the esophagus and multiple primary tumors of the upper aerodigestive tract Carcinoma epidermoide do esôfago e múltiplos tumores primários do trato aerodigestivo alto
Squamous cell carcinoma of the esophagus is frequently associated with other, synchronous or metachronous tumors, in the upper aerodigestive tract. All 264 patients with squamous cell carcinoma of the esophagus, treated in the Gastrointestinal Surgery, Esophagus section, of the "Hospital das Cl...
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| Format: | Article |
| Language: | English |
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Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE)
1999-12-01
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| Series: | Arquivos de Gastroenterologia |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28031999000400006 |
| _version_ | 1818494392532467712 |
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| author | Ulysses RIBEIRO Jr. Ivan CECCONELLO Adriana Vaz SAFATLE-RIBEIRO Bruno ZILBERSTEIN Henrique Walter PINOTTI |
| author_facet | Ulysses RIBEIRO Jr. Ivan CECCONELLO Adriana Vaz SAFATLE-RIBEIRO Bruno ZILBERSTEIN Henrique Walter PINOTTI |
| author_sort | Ulysses RIBEIRO Jr. |
| collection | DOAJ |
| description | Squamous cell carcinoma of the esophagus is frequently associated with other, synchronous or metachronous tumors, in the upper aerodigestive tract. All 264 patients with squamous cell carcinoma of the esophagus, treated in the Gastrointestinal Surgery, Esophagus section, of the "Hospital das Clínicas" (São Paulo University Medical School, Brazil), between 1979 and 1989 were analyzed retrospectively with regards to the occurrence of multiple primary tumors in the upper aerodigestive tract. Multiple primary tumors were encountered in 10 (3.8%) patients. All patients were male and the mean age at the time of the first primary was 52.2 years. Tobacco smoke and alcohol were the principal carcinogens in these patients (n = 10). The sites of the tumors were: larynx (n = 4), tongue (n = 4), lung (n = 2), and oral cavity (n = 1). Two simultaneous, three synchronous and five metachronous multiple primary carcinomas were detected. The esophagus was the second primary tumor in nine patients. The mean overall survival after the diagnosis of the second primary was 2.8 months (SD = 0.89). Inquiry regarding other malignancies, associated with panendoscopy should be carry out prior to the treatment of the first primary to diagnose simultaneous or synchronous primary tumors, and careful follow-up should be performed after treatment of the first primary to detect new tumors in these high-risk patients.<br>Carcinoma epidermóide do esôfago está freqüentemente associado a outros, sincrônicos ou metacrônicos tumores do trato aerodigestivo alto. Foram analisados, retrospectivamente, 264 pacientes com carcinoma de esôfago tratados na Disciplina de Cirurgia do Aparelho Digestivo, Divisão de Cirurgia do Esôfago, do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, entre 1979 e 1989, com o intuito de se observar a ocorrência de múltiplos tumores primários do trato aerodigestivo alto. Observaram-se 10 (3.8%) pacientes com múltiplos tumores primários. Todos eram do sexo masculino e a média de idade ao tempo do primeiro tumor foi 52.2 anos. Os locais dos tumores primários foram: laringe (n = 4), língua (n = 3), pulmão (n =2), cavidade oral (n = 1) e esôfago (n = 1). Dois tumores eram simultâneos, três sincrônicos e cinco metacrônicos. O esôfago foi o segundo tumor primário em nove pacientes. A sobrevida média depois do diagnóstico do segundo tumor primário foi de apenas 2.8 meses (DP = 0.89). Na tentativa de se diagnosticar outros tumores, o exame clínico associado com panendoscopia deve ser realizado antes de se tratar o tumor inicial, a fim de que se possa diagnosticar tumores simultâneos ou sincrônicos. Ademais, deve ser realizado cuidadoso seguimento após o tratamento do primeiro tumor pois estes pacientes apresentam risco de aparecimento de novos tumores. |
| first_indexed | 2024-12-10T18:05:33Z |
| format | Article |
| id | doaj.art-0747ff74997946dfb535e96b24e5abb9 |
| institution | Directory Open Access Journal |
| issn | 0004-2803 1678-4219 |
| language | English |
| last_indexed | 2024-12-10T18:05:33Z |
| publishDate | 1999-12-01 |
| publisher | Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE) |
| record_format | Article |
| series | Arquivos de Gastroenterologia |
| spelling | doaj.art-0747ff74997946dfb535e96b24e5abb92022-12-22T01:38:37ZengInstituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE)Arquivos de Gastroenterologia0004-28031678-42191999-12-0136419520010.1590/S0004-28031999000400006Squamous cell carcinoma of the esophagus and multiple primary tumors of the upper aerodigestive tract Carcinoma epidermoide do esôfago e múltiplos tumores primários do trato aerodigestivo altoUlysses RIBEIRO Jr.Ivan CECCONELLOAdriana Vaz SAFATLE-RIBEIROBruno ZILBERSTEINHenrique Walter PINOTTISquamous cell carcinoma of the esophagus is frequently associated with other, synchronous or metachronous tumors, in the upper aerodigestive tract. All 264 patients with squamous cell carcinoma of the esophagus, treated in the Gastrointestinal Surgery, Esophagus section, of the "Hospital das Clínicas" (São Paulo University Medical School, Brazil), between 1979 and 1989 were analyzed retrospectively with regards to the occurrence of multiple primary tumors in the upper aerodigestive tract. Multiple primary tumors were encountered in 10 (3.8%) patients. All patients were male and the mean age at the time of the first primary was 52.2 years. Tobacco smoke and alcohol were the principal carcinogens in these patients (n = 10). The sites of the tumors were: larynx (n = 4), tongue (n = 4), lung (n = 2), and oral cavity (n = 1). Two simultaneous, three synchronous and five metachronous multiple primary carcinomas were detected. The esophagus was the second primary tumor in nine patients. The mean overall survival after the diagnosis of the second primary was 2.8 months (SD = 0.89). Inquiry regarding other malignancies, associated with panendoscopy should be carry out prior to the treatment of the first primary to diagnose simultaneous or synchronous primary tumors, and careful follow-up should be performed after treatment of the first primary to detect new tumors in these high-risk patients.<br>Carcinoma epidermóide do esôfago está freqüentemente associado a outros, sincrônicos ou metacrônicos tumores do trato aerodigestivo alto. Foram analisados, retrospectivamente, 264 pacientes com carcinoma de esôfago tratados na Disciplina de Cirurgia do Aparelho Digestivo, Divisão de Cirurgia do Esôfago, do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, entre 1979 e 1989, com o intuito de se observar a ocorrência de múltiplos tumores primários do trato aerodigestivo alto. Observaram-se 10 (3.8%) pacientes com múltiplos tumores primários. Todos eram do sexo masculino e a média de idade ao tempo do primeiro tumor foi 52.2 anos. Os locais dos tumores primários foram: laringe (n = 4), língua (n = 3), pulmão (n =2), cavidade oral (n = 1) e esôfago (n = 1). Dois tumores eram simultâneos, três sincrônicos e cinco metacrônicos. O esôfago foi o segundo tumor primário em nove pacientes. A sobrevida média depois do diagnóstico do segundo tumor primário foi de apenas 2.8 meses (DP = 0.89). Na tentativa de se diagnosticar outros tumores, o exame clínico associado com panendoscopia deve ser realizado antes de se tratar o tumor inicial, a fim de que se possa diagnosticar tumores simultâneos ou sincrônicos. Ademais, deve ser realizado cuidadoso seguimento após o tratamento do primeiro tumor pois estes pacientes apresentam risco de aparecimento de novos tumores.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28031999000400006Neoplasias esofágicasCarcinoma de células escamosasNeoplasias primárias múltiplasSistema respiratórioEsophageal neoplasmsCarcinomaNeoplasmsRespiratory system |
| spellingShingle | Ulysses RIBEIRO Jr. Ivan CECCONELLO Adriana Vaz SAFATLE-RIBEIRO Bruno ZILBERSTEIN Henrique Walter PINOTTI Squamous cell carcinoma of the esophagus and multiple primary tumors of the upper aerodigestive tract Carcinoma epidermoide do esôfago e múltiplos tumores primários do trato aerodigestivo alto Arquivos de Gastroenterologia Neoplasias esofágicas Carcinoma de células escamosas Neoplasias primárias múltiplas Sistema respiratório Esophageal neoplasms Carcinoma Neoplasms Respiratory system |
| title | Squamous cell carcinoma of the esophagus and multiple primary tumors of the upper aerodigestive tract Carcinoma epidermoide do esôfago e múltiplos tumores primários do trato aerodigestivo alto |
| title_full | Squamous cell carcinoma of the esophagus and multiple primary tumors of the upper aerodigestive tract Carcinoma epidermoide do esôfago e múltiplos tumores primários do trato aerodigestivo alto |
| title_fullStr | Squamous cell carcinoma of the esophagus and multiple primary tumors of the upper aerodigestive tract Carcinoma epidermoide do esôfago e múltiplos tumores primários do trato aerodigestivo alto |
| title_full_unstemmed | Squamous cell carcinoma of the esophagus and multiple primary tumors of the upper aerodigestive tract Carcinoma epidermoide do esôfago e múltiplos tumores primários do trato aerodigestivo alto |
| title_short | Squamous cell carcinoma of the esophagus and multiple primary tumors of the upper aerodigestive tract Carcinoma epidermoide do esôfago e múltiplos tumores primários do trato aerodigestivo alto |
| title_sort | squamous cell carcinoma of the esophagus and multiple primary tumors of the upper aerodigestive tract carcinoma epidermoide do esofago e multiplos tumores primarios do trato aerodigestivo alto |
| topic | Neoplasias esofágicas Carcinoma de células escamosas Neoplasias primárias múltiplas Sistema respiratório Esophageal neoplasms Carcinoma Neoplasms Respiratory system |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28031999000400006 |
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